STRINGSTRING
FOXO3 FOXO3 BAD BAD DDB2 DDB2 EGF EGF RB1 RB1 PIK3R3 PIK3R3 ARAF ARAF MAPK1 MAPK1 E2F1 E2F1 POLK POLK SOS1 SOS1 STK4 STK4 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 ENSPPAP00000011278 ENSPPAP00000011278 MAP2K2 MAP2K2 BAK1 BAK1 RASSF5 RASSF5 E2F3 E2F3 PRKCA PRKCA PIK3CB PIK3CB RXRG RXRG CDK6 CDK6 PRKCB PRKCB HGF HGF RAF1 RAF1 AKT3 AKT3 BRAF BRAF EML4 EML4 CDK4 CDK4 FHIT FHIT CDKN1A CDKN1A NRAS NRAS MET MET RARB RARB RXRB RXRB PLCG2 PLCG2 STAT5B STAT5B BAX BAX AKT1 AKT1 SOS2 SOS2 STAT3 STAT3 JAK3 JAK3 E2F2 E2F2 ERBB2 ERBB2 RASSF1 RASSF1 PIK3R1 PIK3R1 STAT5A STAT5A RXRA RXRA GADD45A GADD45A TGFA TGFA CASP9 CASP9 ALK ALK GADD45B GADD45B EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXO3Forkhead box O3. (655 aa)
BADBCL2 associated agonist of cell death. (168 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
RB1RB transcriptional corepressor 1. (911 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
E2F1E2F transcription factor 1. (397 aa)
POLKDNA polymerase kappa. (897 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
STK4Serine/threonine kinase 4. (487 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ENSPPAP00000011278Protein kinase domain-containing protein. (351 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RASSF5Ras association domain family member 5. (418 aa)
E2F3E2F transcription factor 3. (420 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RXRGRetinoid X receptor gamma. (473 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
EML4EMAP like 4. (992 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
FHITHIT domain-containing protein. (67 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
RARBRetinoic acid receptor beta. (448 aa)
RXRBRetinoid X receptor beta. (537 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
JAK3Tyrosine-protein kinase. (1090 aa)
E2F2E2F transcription factor 2. (437 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
RASSF1Ras association domain family member 1. (340 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
RXRARetinoid X receptor alpha. (472 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
TGFATransforming growth factor alpha. (181 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
ALKTyrosine-protein kinase receptor. (1312 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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