STRINGSTRING
BCL2L1 BCL2L1 BAD BAD FZD5 FZD5 DDB2 DDB2 PHF10 PHF10 RB1 RB1 RPS6KB2 RPS6KB2 WNT4 WNT4 WNT8A WNT8A PIK3R3 PIK3R3 WNT6 WNT6 WNT11 WNT11 WNT5B WNT5B LOC100991696 LOC100991696 ARAF ARAF CSNK1A1L CSNK1A1L ENSPPAP00000004871 ENSPPAP00000004871 PBRM1 PBRM1 DVL1 DVL1 MAPK1 MAPK1 LOC100987265 LOC100987265 E2F1 E2F1 WNT1 WNT1 POLK POLK MYC MYC WNT2B WNT2B GSTM3 GSTM3 WNT5A WNT5A SOS1 SOS1 IGF1R IGF1R LRP5 LRP5 SMAD4 SMAD4 GRB2 GRB2 PIK3R2 PIK3R2 PIK3CA PIK3CA WNT16 WNT16 SMARCB1 SMARCB1 RPS6KB1 RPS6KB1 SMARCC2 SMARCC2 SHC3 SHC3 FZD9 FZD9 GADD45G GADD45G MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS TP53 TP53 LOC100985734 LOC100985734 MAP2K2 MAP2K2 ARID1B ARID1B GSTO1 GSTO1 TERT TERT BAK1 BAK1 WNT7A WNT7A WNT2 WNT2 FZD7 FZD7 GSTO2 GSTO2 SHC1 SHC1 TGFBR1 TGFBR1 TCF7L1 TCF7L1 E2F3 E2F3 LOC100969075 LOC100969075 SMARCC1 SMARCC1 AXIN1 AXIN1 DVL2 DVL2 TGFB1 TGFB1 PRKCA PRKCA TGFB3 TGFB3 PIK3CB PIK3CB ACTL6A ACTL6A TXNRD1 TXNRD1 FZD3 FZD3 APC APC SMARCD1 SMARCD1 GSTA3 GSTA3 WNT9B WNT9B GSTA4 GSTA4 WNT3A WNT3A SMAD3 SMAD3 AXIN2 AXIN2 TCF7 TCF7 CDK6 CDK6 PRKCB PRKCB MGST1 MGST1 MGST2 MGST2 LRP6 LRP6 GSTA2 GSTA2 ACTL6B ACTL6B HGF HGF RAF1 RAF1 GSTT2B GSTT2B ARID1A ARID1A FZD6 FZD6 SMAD2 SMAD2 CTNNB1 CTNNB1 WNT10B WNT10B AKT3 AKT3 IGF2 IGF2 BRAF BRAF HMOX1 HMOX1 MTOR MTOR GSTM4 GSTM4 WNT7B WNT7B CDK4 CDK4 ACTG1 ACTG1 DPF3 DPF3 NFE2L2 NFE2L2 WNT3 WNT3 CDKN1A CDKN1A SMARCE1 SMARCE1 NRAS NRAS MET MET BRD7 BRD7 KEAP1 KEAP1 SMARCA2 SMARCA2 TXNRD3 TXNRD3 SMARCD3 SMARCD3 GAB1 GAB1 GSTA5 GSTA5 LOC100995377 LOC100995377 PLCG2 PLCG2 WNT8B WNT8B FZD4 FZD4 BAX BAX AKT1 AKT1 WNT9A WNT9A SOS2 SOS2 GSK3B GSK3B E2F2 E2F2 WNT10A WNT10A DVL3 DVL3 SHC4 SHC4 TXNRD2 TXNRD2 PIK3R1 PIK3R1 GADD45A GADD45A DPF1 DPF1 LEF1 LEF1 TGFA TGFA ELK1 ELK1 GSTP1 GSTP1 SHC2 SHC2 ARID2 ARID2 SMARCA4 SMARCA4 GADD45B GADD45B EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1BCL2 like 1. (233 aa)
BADBCL2 associated agonist of cell death. (168 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
PHF10PHD finger protein 10. (469 aa)
RB1RB transcriptional corepressor 1. (911 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LOC100991696Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
ENSPPAP00000004871GST N-terminal domain-containing protein. (67 aa)
PBRM1Polybromo 1. (1690 aa)
DVL1Dishevelled segment polarity protein 1. (674 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
LOC100987265Glutathione S-transferase. (162 aa)
E2F1E2F transcription factor 1. (397 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
POLKDNA polymerase kappa. (897 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
GSTM3Glutathione S-transferase. (225 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (366 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1318 aa)
IGF1RTyrosine-protein kinase receptor. (1389 aa)
LRP5LDL receptor related protein 5. (1839 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
SHC3SHC adaptor protein 3. (501 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (517 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
LOC100985734Glutathione S-transferase. (222 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
ARID1BARID domain-containing protein. (1539 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1040 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (571 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
SHC1SHC adaptor protein 1. (584 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TCF7L1Transcription factor 7 like 1. (560 aa)
E2F3E2F transcription factor 3. (420 aa)
LOC100969075Glutathione S-transferase. (196 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1087 aa)
AXIN1Axin 1. (862 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (625 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
ACTL6AActin like 6A; Belongs to the actin family. (430 aa)
TXNRD1Thioredoxin reductase 1. (648 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AXIN2Axin 2. (843 aa)
TCF7HMG box domain-containing protein. (391 aa)
CDK6Protein kinase domain-containing protein. (84 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (615 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
GSTA2Glutathione S-transferase alpha 2. (222 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (812 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (244 aa)
ARID1AAT-rich interaction domain 1A. (2150 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IGF2Insulin like growth factor 2. (236 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GSTM4Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ACTG1Actin gamma 1. (375 aa)
DPF3Uncharacterized protein. (378 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
BRD7Bromodomain containing 7. (644 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1566 aa)
TXNRD3Thioredoxin reductase 3. (642 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (430 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
GSTA5Glutathione S-transferase alpha 5. (222 aa)
LOC100995377Uncharacterized protein. (557 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
BAXBCL2 associated X, apoptosis regulator. (218 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1325 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa)
E2F2E2F transcription factor 2. (437 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (414 aa)
DVL3Dishevelled segment polarity protein 3. (718 aa)
SHC4SHC adaptor protein 4. (630 aa)
TXNRD2Thioredoxin reductase 2. (517 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
DPF1Double PHD fingers 1. (408 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
TGFATransforming growth factor alpha. (181 aa)
ELK1ETS transcription factor ELK1. (428 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
SHC2Uncharacterized protein. (539 aa)
ARID2AT-rich interaction domain 2. (1835 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (32%) [HD]