STRINGSTRING
PFKP PFKP SCO2 SCO2 PIK3R3 PIK3R3 FLT3 FLT3 LDHAL6B LDHAL6B LDHAL6A LDHAL6A MAPK1 MAPK1 GLS GLS MYC MYC SLC7A5 SLC7A5 PFKL PFKL GLS2 GLS2 PIK3R2 PIK3R2 PIK3CA PIK3CA PGAM1 PGAM1 MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS HIF1A HIF1A TP53 TP53 TIGAR TIGAR MAP2K2 MAP2K2 GCK GCK FGFR1 FGFR1 PIK3CB PIK3CB PDGFRA PDGFRA IDH2 IDH2 KIT KIT PGAM2 PGAM2 PDHA1 PDHA1 ENSPPAP00000020512 ENSPPAP00000020512 LDHB LDHB SLC2A1 SLC2A1 RET RET SIRT3 SIRT3 FGFR3 FGFR3 SIRT6 SIRT6 SLC16A3 SLC16A3 NTRK1 NTRK1 FGFR2 FGFR2 RAF1 RAF1 HKDC1 HKDC1 AKT3 AKT3 MTOR MTOR HK3 HK3 PDGFRB PDGFRB PFKM PFKM NRAS NRAS MET MET LDHC LDHC LOC100994201 LOC100994201 HK2 HK2 SLC2A2 SLC2A2 IDH1 IDH1 LOC100995377 LOC100995377 HK1 HK1 AKT1 AKT1 PKM PKM ERBB2 ERBB2 PIK3R1 PIK3R1 NTRK3 NTRK3 PDK1 PDK1 LDHA LDHA EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (978 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
GLSGlutaminase. (565 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
SLC7A5Uncharacterized protein. (241 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (771 aa)
GLS2Glutaminase 2. (602 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
GCKPhosphotransferase. (463 aa)
FGFR1Fibroblast growth factor receptor. (812 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (428 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (463 aa)
ENSPPAP00000020512Uncharacterized protein; Belongs to the LDH/MDH superfamily. (350 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (342 aa)
FGFR3Fibroblast growth factor receptor. (780 aa)
SIRT6Sirtuin 6. (355 aa)
SLC16A3Solute carrier family 16 member 3. (465 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
HK3Hexokinase 3. (923 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1413 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
LOC100994201L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (363 aa)
HK2Hexokinase 2. (917 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
LOC100995377Uncharacterized protein. (557 aa)
HK1Hexokinase 1. (921 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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