STRINGSTRING
EGF EGF TICAM2 TICAM2 TIRAP TIRAP RPS6KB2 RPS6KB2 PPP3CB PPP3CB ZAP70 ZAP70 NFKBIB NFKBIB PIK3R3 PIK3R3 CD3D CD3D JAK1 JAK1 LOC100986336 LOC100986336 IKBKG IKBKG FOS FOS MAPK1 MAPK1 IFNGR2 IFNGR2 CD3G CD3G TLR2 TLR2 PTPN6 PTPN6 PIK3R2 PIK3R2 BATF3 BATF3 PIK3CA PIK3CA RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 AKT2 AKT2 HRAS HRAS HIF1A HIF1A PRKCQ PRKCQ NFKBIE NFKBIE MAP2K2 MAP2K2 MAPK12 MAPK12 NFATC1 NFATC1 LCK LCK TLR4 TLR4 PIK3CB PIK3CB CD3E CD3E NFKB1 NFKB1 IFNGR1 IFNGR1 CSNK2A3 CSNK2A3 RELA RELA IKBKB IKBKB CD274 CD274 CD4 CD4 CD28 CD28 RAF1 RAF1 MAP3K3 MAP3K3 AKT3 AKT3 PTPN11 PTPN11 MAPK11 MAPK11 EML4 EML4 BATF2 BATF2 MTOR MTOR MAP2K6 MAP2K6 MYD88 MYD88 MAPK13 MAPK13 CHUK CHUK NRAS NRAS BATF BATF RASGRP1 RASGRP1 LOC100995377 LOC100995377 CSNK2A2 CSNK2A2 STAT1 STAT1 AKT1 AKT1 NFATC2 NFATC2 STAT3 STAT3 NFATC3 NFATC3 NFKBIA NFKBIA MAPK14 MAPK14 IFNG IFNG PIK3R1 PIK3R1 PPP3CA PPP3CA TRAF6 TRAF6 CD247 CD247 ALK ALK EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
TICAM2TIR domain-containing adaptor molecule 2. (235 aa)
TIRAPTIR domain-containing protein. (226 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
NFKBIBANK_REP_REGION domain-containing protein. (270 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
CD3DCD3d molecule. (171 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
LOC100986336TIR domain-containing protein. (1033 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK1Mitogen-activated protein kinase. (339 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
CD3GCD3g molecule. (182 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (603 aa)
PIK3R2Uncharacterized protein. (663 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (127 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (758 aa)
NFKBIENFKB inhibitor epsilon. (486 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (392 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
NFATC1Nuclear factor of activated T cells 1. (975 aa)
LCKTyrosine-protein kinase. (524 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CD3ECD3e molecule. (207 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CSNK2A3Casein kinase 2 alpha 1; Belongs to the protein kinase superfamily. (391 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
CD274CD274 molecule. (290 aa)
CD4CD4 molecule. (458 aa)
CD28CD28 molecule. (220 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (655 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
EML4EMAP like 4. (992 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (274 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (317 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
RASGRP1RAS guanyl releasing protein 1. (843 aa)
LOC100995377Uncharacterized protein. (557 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (323 aa)
STAT1Signal transducer and activator of transcription. (759 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
NFATC2Nuclear factor of activated T cells 2. (912 aa)
STAT3Signal transducer and activator of transcription. (781 aa)
NFATC3Nuclear factor of activated T cells 3. (1064 aa)
NFKBIAANK_REP_REGION domain-containing protein. (456 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
CD247CD247 molecule. (163 aa)
ALKTyrosine-protein kinase receptor. (1312 aa)
EGFRReceptor protein-tyrosine kinase. (1201 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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