(59 nodes) Inflammatory bowel disease network (Pan paniscus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IL10	Interleukin 10. (178 aa)
	TLR5	Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IL23R	Interleukin 23 receptor. (629 aa)
	LOC100979649	Ig-like domain-containing protein. (170 aa)
	IFNGR2	Interferon gamma receptor 2. (347 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	GATA3	GATA binding protein 3. (444 aa)
	IL22	Interleukin 22. (179 aa)
	RORC	RAR related orphan receptor C. (525 aa)
	HLA-DOB	Major histocompatibility complex, class II, DO beta. (266 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	LOC100993508	Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL17A	Interleukin 17A. (155 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (740 aa)
	IL18RAP	Interleukin 18 receptor accessory protein. (599 aa)
	STAT6	Signal transducer and activator of transcription. (852 aa)
	LOC100986750	Ig-like domain-containing protein. (287 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
	IL13	Interleukin 13. (146 aa)
	NFATC1	Nuclear factor of activated T cells 1. (975 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (271 aa)
	IFNGR1	Interferon gamma receptor 1. (489 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (662 aa)
	IL6	Uncharacterized protein. (198 aa)
	IL18R1	Uncharacterized protein. (440 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	MHC-DMB	Ig-like domain-containing protein. (276 aa)
	HLA-DQA2	Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
	RORA	RAR related orphan receptor A. (559 aa)
	STAT4	Signal transducer and activator of transcription. (742 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	LOC100993847	Ig-like domain-containing protein. (270 aa)
	IL17F	Interleukin 17F. (163 aa)
	STAT1	Signal transducer and activator of transcription. (759 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (369 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	STAT3	Signal transducer and activator of transcription. (781 aa)
	HLA-DQB1	Major histocompatibility complex, class II, DQ beta 1. (261 aa)
	HLA-DQB2	Major histocompatibility complex, class II, DQ beta 2. (264 aa)
	IL21R	Interleukin 21 receptor. (538 aa)
	HLA-DPB1	Major histocompatibility complex, class II, DP beta 1. (258 aa)
	IL4R	Interleukin 4 receptor. (873 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1040 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA3	IFNG	ENSPPAP00000007588	ENSPPAP00000038608	GATA binding protein 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.762
GATA3	IL10	ENSPPAP00000007588	ENSPPAP00000001878	GATA binding protein 3.	Interleukin 10.	0.567
GATA3	IL13	ENSPPAP00000007588	ENSPPAP00000015240	GATA binding protein 3.	Interleukin 13.	0.739
GATA3	IL17A	ENSPPAP00000007588	ENSPPAP00000010972	GATA binding protein 3.	Interleukin 17A.	0.581
GATA3	IL17F	ENSPPAP00000007588	ENSPPAP00000033390	GATA binding protein 3.	Interleukin 17F.	0.461
GATA3	IL18R1	ENSPPAP00000007588	ENSPPAP00000025885	GATA binding protein 3.	Uncharacterized protein.	0.511
GATA3	IL1B	ENSPPAP00000007588	ENSPPAP00000034853	GATA binding protein 3.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.461
GATA3	IL2	ENSPPAP00000007588	ENSPPAP00000014571	GATA binding protein 3.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.577
GATA3	IL22	ENSPPAP00000007588	ENSPPAP00000007818	GATA binding protein 3.	Interleukin 22.	0.583
GATA3	IL4	ENSPPAP00000007588	ENSPPAP00000008567	GATA binding protein 3.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.778
GATA3	IL5	ENSPPAP00000007588	ENSPPAP00000041815	GATA binding protein 3.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.750
GATA3	IL6	ENSPPAP00000007588	ENSPPAP00000025189	GATA binding protein 3.	Uncharacterized protein.	0.495
GATA3	NFATC1	ENSPPAP00000007588	ENSPPAP00000015289	GATA binding protein 3.	Nuclear factor of activated T cells 1.	0.492
GATA3	NFKB1	ENSPPAP00000007588	ENSPPAP00000017939	GATA binding protein 3.	Nuclear factor kappa B subunit 1.	0.562
GATA3	RELA	ENSPPAP00000007588	ENSPPAP00000018755	GATA binding protein 3.	RELA proto-oncogene, NF-kB subunit.	0.435
GATA3	RORA	ENSPPAP00000007588	ENSPPAP00000030398	GATA binding protein 3.	RAR related orphan receptor A.	0.561
GATA3	RORC	ENSPPAP00000007588	ENSPPAP00000007845	GATA binding protein 3.	RAR related orphan receptor C.	0.675
GATA3	SMAD3	ENSPPAP00000007588	ENSPPAP00000021162	GATA binding protein 3.	Mothers against decapentaplegic homolog.	0.589
GATA3	STAT1	ENSPPAP00000007588	ENSPPAP00000033854	GATA binding protein 3.	Signal transducer and activator of transcription.	0.627
GATA3	STAT3	ENSPPAP00000007588	ENSPPAP00000035951	GATA binding protein 3.	Signal transducer and activator of transcription.	0.681