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LOC100992309 LOC100992309 ATP6V1G1 ATP6V1G1 CCL20 CCL20 LOC100990258 LOC100990258 ATP6V1D ATP6V1D TNF TNF LOC100979649 LOC100979649 FOS FOS ACP5 ACP5 TNFRSF11A TNFRSF11A TNFSF13B TNFSF13B TNFSF13 TNFSF13 ATP6V1B1 ATP6V1B1 LOC100967628 LOC100967628 TLR2 TLR2 HLA-DOB HLA-DOB ENSPPAP00000008696 ENSPPAP00000008696 LOC100993508 LOC100993508 ENSPPAP00000009755 ENSPPAP00000009755 IL18 IL18 IL17A IL17A PTH PTH LOC100986750 LOC100986750 CXCL8 CXCL8 TCIRG1 TCIRG1 ATP6V1C1 ATP6V1C1 CTSL CTSL CXCL1 CXCL1 TLR4 TLR4 TGFB1 TGFB1 TGFB3 TGFB3 HLA-DPA1 HLA-DPA1 ATP6V0A4 ATP6V0A4 IL1A IL1A ATP6V1G2 ATP6V1G2 ATP6V0D2 ATP6V0D2 ATP6V1E2 ATP6V1E2 CCL2 CCL2 FLT1 FLT1 CD86 CD86 ICAM1 ICAM1 TEK TEK CXCL5 CXCL5 ATP6V0A1 ATP6V0A1 TNFSF11 TNFSF11 CD28 CD28 IL6 IL6 MMP3 MMP3 ATP6AP1 ATP6AP1 HLA-DOA HLA-DOA ATP6V0A2 ATP6V0A2 ATP6V0E1 ATP6V0E1 CXCL6 CXCL6 ATP6V1E1 ATP6V1E1 MHC-DMB MHC-DMB HLA-DQA2 HLA-DQA2 ATP6V1H ATP6V1H LOC100993847 LOC100993847 CXCL2 CXCL2 CD80 CD80 LTB LTB ATP6V0B ATP6V0B IL11 IL11 IL1B IL1B LOC103785316 LOC103785316 MMP1 MMP1 CXCL12 CXCL12 ITGAL ITGAL CSF2 CSF2 HLA-DQB1 HLA-DQB1 HLA-DQB2 HLA-DQB2 ATP6V0C ATP6V0C HLA-DPB1 HLA-DPB1 CTSK CTSK CTLA4 CTLA4 ATP6V1A ATP6V1A HLA-DRA HLA-DRA IFNG IFNG CSF1 CSF1 IL23A IL23A ATP6V1B2 ATP6V1B2 IL15 IL15 CCL5 CCL5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100992309C-C motif chemokine. (92 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
CCL20C-C motif chemokine. (96 aa)
LOC100990258V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ATP6V1DUncharacterized protein. (192 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC100979649Ig-like domain-containing protein. (170 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
TNFRSF11ATNF receptor superfamily member 11a. (615 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (250 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
LOC100967628C-C motif chemokine. (93 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (266 aa)
ENSPPAP00000008696Ig-like domain-containing protein. (147 aa)
LOC100993508Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
ENSPPAP00000009755Ig-like domain-containing protein. (116 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IL17AInterleukin 17A. (155 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
LOC100986750Ig-like domain-containing protein. (287 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
CXCL1C-X-C motif chemokine. (107 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (839 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (782 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
CCL2C-C motif chemokine. (99 aa)
FLT1Uncharacterized protein. (736 aa)
CD86CD86 molecule. (329 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
CXCL5C-X-C motif chemokine. (114 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
CD28CD28 molecule. (220 aa)
IL6Uncharacterized protein. (198 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (250 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
CXCL6C-X-C motif chemokine. (114 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
MHC-DMBIg-like domain-containing protein. (276 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
LOC100993847Ig-like domain-containing protein. (270 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CD80CD80 molecule. (288 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (243 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (261 aa)
IL11Interleukin 11. (199 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1039 aa)
CSF2Colony stimulating factor 2. (144 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (261 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (618 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (525 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CCL5C-C motif chemokine. (91 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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