STRINGSTRING
SLC8A1 SLC8A1 TPM1 TPM1 SGCG SGCG CACNB3 CACNB3 PRKACG PRKACG PRKACA PRKACA IGF1 IGF1 ADCY9 ADCY9 CACNA2D3 CACNA2D3 TNF TNF ITGB4 ITGB4 SLC8A3 SLC8A3 PLN PLN ITGB5 ITGB5 TPM3-2 TPM3-2 CACNG2 CACNG2 ADCY7 ADCY7 CACNA2D1 CACNA2D1 ITGA6 ITGA6 CACNG1 CACNG1 AGT AGT ITGA9 ITGA9 EMD EMD ENSPPAP00000008696 ENSPPAP00000008696 CACNA1F CACNA1F SGCD SGCD MYL2 MYL2 ENSPPAP00000009755 ENSPPAP00000009755 CACNB4 CACNB4 LAMA2 LAMA2 ACTC1 ACTC1 DES DES SLC8A2 SLC8A2 ITGB3 ITGB3 ITGA10 ITGA10 ITGA11 ITGA11 TPM2 TPM2 CACNG4 CACNG4 ADCY6 ADCY6 LOC100979041 LOC100979041 ITGA8 ITGA8 MYBPC3 MYBPC3 LAMA1 LAMA1 CACNG6 CACNG6 CACNA1C CACNA1C CACNA2D4 CACNA2D4 TGFB1 TGFB1 TGFB3 TGFB3 PRKACB PRKACB CACNB2 CACNB2 GNAS GNAS GNAS-2 GNAS-2 TNNI3 TNNI3 ITGA3 ITGA3 TPM3 TPM3 TTN TTN ADCY2 ADCY2 ITGA1 ITGA1 DAG1 DAG1 ITGAV ITGAV SGCB SGCB ADCY5 ADCY5 ITGA7 ITGA7 ITGA4 ITGA4 ATP2A1 ATP2A1 TNNC1 TNNC1 ACTG1 ACTG1 CACNG3 CACNG3 ADCY8 ADCY8 ITGB7 ITGB7 MYH6 MYH6 LMNA LMNA MYL3 MYL3 ADCY3 ADCY3 ADCY4 ADCY4 MYH7 MYH7 ATP2A3 ATP2A3 ITGB1 ITGB1 ADCY1 ADCY1 CACNA2D2 CACNA2D2 ITGA2B ITGA2B TPM4 TPM4 CACNG5 CACNG5 CACNA1S CACNA1S LOC103785316 LOC103785316 ITGA5 ITGA5 ITGB6 ITGB6 ATP2A2 ATP2A2 CACNA1D CACNA1D SGCA SGCA ITGB8 ITGB8 RYR2 RYR2 ITGA2 ITGA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
SGCGSarcoglycan gamma. (291 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (488 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
IGF1IlGF domain-containing protein. (196 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1067 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ITGB4Integrin beta. (1821 aa)
SLC8A3Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (210 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (803 aa)
TPM3-2Uncharacterized protein. (92 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1096 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1020 aa)
EMDEmerin. (254 aa)
ENSPPAP00000008696Ig-like domain-containing protein. (147 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1974 aa)
SGCDSarcoglycan delta. (290 aa)
MYL2Myosin light chain 2. (166 aa)
ENSPPAP00000009755Ig-like domain-containing protein. (116 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
DESDesmin; Belongs to the intermediate filament family. (518 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (908 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1178 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (322 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (339 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
LOC100979041Uncharacterized protein. (245 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (240 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1154 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (388 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
GNASGNAS complex locus. (1043 aa)
GNAS-2Uncharacterized protein. (245 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
TPM3Uncharacterized protein; Belongs to the tropomyosin family. (285 aa)
TTNUncharacterized protein. (27117 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1049 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
DAG1Dystroglycan 1. (895 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
SGCBSarcoglycan beta. (334 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1056 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (873 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
ACTG1Actin gamma 1. (375 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (802 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
MYL3Myosin light chain 3. (195 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1017 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1126 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
LOC103785316Ig-like domain-containing protein. (221 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1046 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1034 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SGCASarcoglycan alpha. (387 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (757 aa)
RYR2Ryanodine receptor 2. (4948 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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