STRINGSTRING
SUMO3 SUMO3 MAPK8 MAPK8 PIK3R3 PIK3R3 PDGFA PDGFA PLAT PLAT LOC100991696 LOC100991696 LOC100986914 LOC100986914 BMPR2 BMPR2 PECAM1 PECAM1 TNF TNF TNFRSF1A TNFRSF1A THBD THBD IKBKG IKBKG ENSPPAP00000004871 ENSPPAP00000004871 FOS FOS NOX1 NOX1 BMPR1B BMPR1B CALML5 CALML5 LOC100987265 LOC100987265 CALML3 CALML3 SDC4 SDC4 GSTM3 GSTM3 NPPC NPPC MAP3K7 MAP3K7 MAP2K4 MAP2K4 PIK3R2 PIK3R2 PIK3CA PIK3CA DUSP1 DUSP1 AKT2 AKT2 BMP4 BMP4 TP53 TP53 IL1R2 IL1R2 LOC100985734 LOC100985734 GSTO1 GSTO1 MAPK12 MAPK12 PDGFB PDGFB TRPV4 TRPV4 EDN1 EDN1 ITGB3 ITGB3 CTSL CTSL GSTO2 GSTO2 LOC100983479 LOC100983479 LOC100980635 LOC100980635 LOC100969075 LOC100969075 RAC2 RAC2 RHOA RHOA NCF1 NCF1 PIK3CB PIK3CB BCL2 BCL2 NFKB1 NFKB1 IL1A IL1A PIAS4 PIAS4 RELA RELA RAC1 RAC1 GSTA3 GSTA3 CCL2 CCL2 HSP90AB1 HSP90AB1 GSTA4 GSTA4 CALML4 CALML4 LOC100989777 LOC100989777 ICAM1 ICAM1 IKBKB IKBKB SQSTM1 SQSTM1 SDC2 SDC2 MGST1 MGST1 MGST2 MGST2 GSTA2 GSTA2 MEF2A MEF2A ASS1 ASS1 GSTT2B GSTT2B LOC100977183 LOC100977183 CTNNB1 CTNNB1 AKT3 AKT3 CDH5 CDH5 PRKAA1 PRKAA1 ITGAV ITGAV MAPK11 MAPK11 HMOX1 HMOX1 GSTM4 GSTM4 CAV1 CAV1 GPC1 GPC1 MAP2K5 MAP2K5 ACVR1 ACVR1 ACTG1 ACTG1 MAP2K6 MAP2K6 NFE2L2 NFE2L2 CALM3 CALM3 SDC1 SDC1 MAPK13 MAPK13 CHUK CHUK MAPK9 MAPK9 NCF2 NCF2 MMP9 MMP9 KEAP1 KEAP1 HSP90B1 HSP90B1 MAP2K7 MAP2K7 NOS3 NOS3 HSP90AA1 HSP90AA1 IL1R1 IL1R1 GSTA5 GSTA5 MAPK7 MAPK7 BMPR1A BMPR1A ITGA2B ITGA2B CALML6 CALML6 MMP2 MMP2 IL1B IL1B AKT1 AKT1 MAP3K5 MAP3K5 SRC SRC SELE SELE TXN2 TXN2 CAV3 CAV3 MAPK14 MAPK14 IFNG IFNG PIK3R1 PIK3R1 CAV2 CAV2 TXN TXN PRKCZ PRKCZ KDR KDR MAPK10 MAPK10 ACVR2B ACVR2B GSTP1 GSTP1 ARHGEF2 ARHGEF2 PRKAA2 PRKAA2 ACVR2A ACVR2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUMO3Small ubiquitin-related modifier. (103 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (227 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
LOC100991696Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
LOC100986914Uncharacterized protein. (210 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1012 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (738 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
THBDThrombomodulin. (631 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
ENSPPAP00000004871GST N-terminal domain-containing protein. (67 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NOX1NADPH oxidase 1. (564 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CALML5Calmodulin like 5. (146 aa)
LOC100987265Glutathione S-transferase. (162 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (199 aa)
GSTM3Glutathione S-transferase. (225 aa)
NPPCNatriuretic peptide C. (126 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (371 aa)
PIK3R2Uncharacterized protein. (663 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BMP4TGF_BETA_2 domain-containing protein. (402 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
LOC100985734Glutathione S-transferase. (222 aa)
GSTO1Glutathione S-transferase omega 1. (241 aa)
MAPK12Mitogen-activated protein kinase. (316 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
EDN1Endothelin 1. (212 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (814 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
LOC100983479Thioredoxin domain-containing protein. (106 aa)
LOC100980635Uncharacterized protein. (361 aa)
LOC100969075Glutathione S-transferase. (196 aa)
RAC2Rac family small GTPase 2. (192 aa)
RHOAUncharacterized protein. (206 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BCL2BCL2 apoptosis regulator. (193 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
PIAS4Protein inhibitor of activated STAT 4. (573 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RAC1Uncharacterized protein. (224 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
CCL2C-C motif chemokine. (99 aa)
HSP90AB1HATPase_c domain-containing protein. (688 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
CALML4Calmodulin like 4. (196 aa)
LOC100989777Uncharacterized protein. (191 aa)
ICAM1Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (537 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
SQSTM1Sequestosome 1. (440 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
GSTA2Glutathione S-transferase alpha 2. (222 aa)
MEF2AMyocyte enhancer factor 2A. (505 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
GSTT2BUncharacterized protein; Belongs to the GST superfamily. (244 aa)
LOC100977183Uncharacterized protein. (448 aa)
CTNNB1Catenin beta 1. (781 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1048 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
GSTM4Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (636 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
ACTG1Actin gamma 1. (375 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (149 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (334 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (719 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (408 aa)
NOS3Nitric oxide synthase 3. (997 aa)
HSP90AA1HATPase_c domain-containing protein. (854 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
GSTA5Glutathione S-transferase alpha 5. (222 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (816 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
CALML6Calmodulin like 6. (181 aa)
MMP2Matrix metallopeptidase 2. (664 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
AKT1Non-specific serine/threonine protein kinase. (501 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1356 aa)
SRCTyrosine-protein kinase. (458 aa)
SELESelectin E. (612 aa)
TXN2Thioredoxin 2. (201 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (736 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1017 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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