STRINGSTRING
LOC742456 LOC742456 FABP3 FABP3 CASQ2 CASQ2 S100A1 S100A1 LMNA LMNA CRP CRP ACTA1 ACTA1 AGT AGT NPPA NPPA NEBL NEBL ANKRD1 ANKRD1 CSRP3 CSRP3 MYBPC3 MYBPC3 KCNK7 KCNK7 CRYAB CRYAB GAPDH GAPDH ATP2A2 ATP2A2 HCN4 HCN4 TCAP TCAP CKM CKM ZFP28 ZFP28 FKBP1B FKBP1B NCOA1 NCOA1 TTN TTN MYL3 MYL3 TNNC1 TNNC1 ADCY5 ADCY5 MYOZ2 MYOZ2 NKX2-5 NKX2-5 CYCS CYCS MYL7 MYL7 TRIM55 TRIM55 ACE ACE MYBPHL MYBPHL PDE3A PDE3A KCNH2 KCNH2 GPX3 GPX3 HHATL HHATL TNNI3 TNNI3 REN REN CASP3 CASP3 MB MB ACTB ACTB ND4 ND4 ATP6 ATP6 ATP8 ATP8 ND3 ND3 COX2 COX2 ND5 ND5 COX3 COX3 CYTB CYTB ND2 ND2 MT-ND1 MT-ND1 COX1 COX1 ND4L ND4L ND6 ND6 ENSPTRP00000063547 ENSPTRP00000063547 RYR2 RYR2 ENSPTRP00000064849 ENSPTRP00000064849 C10H10orf113 C10H10orf113 ENSPTRP00000066542 ENSPTRP00000066542 LOC736481 LOC736481 IL6 IL6 RPL3L RPL3L ENSPTRP00000068695 ENSPTRP00000068695 ENSPTRP00000068927 ENSPTRP00000068927 ATP2B4 ATP2B4 SCN5A SCN5A TNNT2 TNNT2 ENSPTRP00000073268 ENSPTRP00000073268 MEF2D MEF2D GATA4 GATA4 MYL2 MYL2 ACTN2 ACTN2 IL6-2 IL6-2 NPPB NPPB MYH7 MYH7 LOC104002760 LOC104002760 DES DES ENSPTRP00000082589 ENSPTRP00000082589 AKT1 AKT1 FHL2 FHL2 KCNA7 KCNA7 GJA5 GJA5 ENSPTRP00000086934 ENSPTRP00000086934 STOML2 STOML2 CAMK2D CAMK2D MYH6 MYH6 PLA2G4F PLA2G4F ENSPTRP00000090828 ENSPTRP00000090828 ENSPTRP00000091918 ENSPTRP00000091918
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC742456Cytochrome c-like. (105 aa)
FABP3Fatty acid binding protein 3, muscle and heart (Mammary-derived growth inhibitor); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
S100A1Protein S100; Belongs to the S-100 family. (147 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
CRPPentaxin. (224 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
NPPANatriuretic peptide A. (153 aa)
NEBLNEBL isoform 5. (1014 aa)
ANKRD1Ankyrin repeat domain 1 (Cardiac muscle). (319 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
MYBPC3Myosin binding protein C, cardiac. (1274 aa)
KCNK7Potassium channel subfamily K member. (307 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
TCAPTCAP isoform 1. (167 aa)
CKMCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
ZFP28ZFP28 zinc finger protein. (868 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
TTNTTN isoform 3. (32000 aa)
MYL3Myosin, light chain 3, alkali ventricular, skeletal, slow. (224 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1236 aa)
MYOZ2MYOZ2 isoform 1. (264 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
MYL7Myosin light chain 7. (175 aa)
TRIM55Tripartite motif containing 55. (548 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
MYBPHLMyosin binding protein H like. (354 aa)
PDE3APhosphodiesterase. (1141 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
GPX3GPX3 isoform 3. (225 aa)
HHATLHedgehog acyltransferase like; Belongs to the membrane-bound acyltransferase family. (504 aa)
TNNI3TNNI3 isoform 2. (169 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (277 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (378 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa)
ATP6ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (226 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (68 aa)
ND3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (115 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (603 aa)
COX3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
MT-ND1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (318 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (513 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (174 aa)
ENSPTRP00000063547Cytochrome c. (105 aa)
RYR2RYR2 isoform 1. (4941 aa)
ENSPTRP00000064849annotation not available (150 aa)
C10H10orf113C10orf113 isoform 2. (79 aa)
ENSPTRP00000066542annotation not available (98 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
RPL3LRibosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family. (412 aa)
ENSPTRP00000068695annotation not available (105 aa)
ENSPTRP00000068927annotation not available (480 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
TNNT2Troponin T type 2 (Cardiac). (298 aa)
ENSPTRP00000073268annotation not available (98 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
GATA4GATA binding protein 4. (443 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
ACTN2ACTN2 isoform 2. (894 aa)
IL6-2Interleukin 6. (234 aa)
NPPBNatriuretic peptide B. (134 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
LOC104002760Cytochrome c. (110 aa)
DESDES isoform 1; Belongs to the intermediate filament family. (518 aa)
ENSPTRP00000082589annotation not available (140 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
FHL2FHL2 isoform 4. (389 aa)
KCNA7Potassium voltage-gated channel subfamily A member 7; Belongs to the potassium channel family. (456 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ENSPTRP00000086934annotation not available (467 aa)
STOML2Stomatin (EPB72)-like 2. (361 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
PLA2G4FPhospholipase A2. (849 aa)
ENSPTRP00000090828annotation not available (98 aa)
ENSPTRP00000091918annotation not available (454 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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