41 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MMP20	Matrix metallopeptidase 20. (483 aa)
	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6. (854 aa)
	PAX6	PAX6 isoform 13. (436 aa)
	KCNMB2	Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (263 aa)
	PAX2	PAX2 isoform 1. (417 aa)
	SOX11	Transcription factor SOX. (441 aa)
	CHRD	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
	ENAM	ENAM isoform 1. (1142 aa)
	CNKSR1	CNKSR1 isoform 5. (720 aa)
	LEFTY1	Left-right determination factor. (366 aa)
	PDLIM7	PDZ and LIM domain 7 (Enigma). (459 aa)
	CGN	CGN isoform 6. (1210 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	ENSPTRP00000074429	annotation not available (586 aa)
	SLC4A7	Anion exchange protein. (1259 aa)
	RNF217	RBR-type E3 ubiquitin transferase. (542 aa)
	ZIC1	Zic family member 1. (447 aa)
	NET1	Neuroepithelial cell transforming 1. (603 aa)
	PRPF3	U4/U6 small nuclear ribonucleoprotein Prp3. (683 aa)
	COX1	Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (513 aa)
	SOX1	SOX1 isoform 1. (391 aa)
	MSX1	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
	DEFB113	Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)
	FOXE3	FOXE3 isoform 1. (319 aa)
	FOXD3	FOXD3 isoform 1. (478 aa)
	PPP4R1	Protein phosphatase 4, regulatory subunit 1. (950 aa)
	SOX2	SRY-box transcription factor 2. (319 aa)
	SOX10	SRY-box transcription factor 10. (466 aa)
	AMBN	AMBN isoform 1. (447 aa)
	CER1	CER1 isoform 1. (267 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	DMP1	Dentin matrix acidic phosphoprotein 1. (513 aa)
	DSPP	DSPP isoform 1. (1292 aa)
	AMTN	AMTN isoform 1. (209 aa)
	ODAM	Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. (279 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	SIX3	SIX homeobox 3. (331 aa)
	KLK4	Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
	OTX2	Orthodenticle homeobox 2. (297 aa)
	PAX9	Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. (347 aa)
	NES	NES isoform 1; Belongs to the intermediate filament family. (1620 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMTN	ENSPTRP00000041774	ENSPTRP00000027734	AMBN isoform 1.	AMTN isoform 1.	0.944
AMBN	DMP1	ENSPTRP00000041774	ENSPTRP00000027932	AMBN isoform 1.	Dentin matrix acidic phosphoprotein 1.	0.718
AMBN	DSPP	ENSPTRP00000041774	ENSPTRP00000027930	AMBN isoform 1.	DSPP isoform 1.	0.801
AMBN	ENAM	ENSPTRP00000041774	ENSPTRP00000082702	AMBN isoform 1.	ENAM isoform 1.	0.969
AMBN	KLK4	ENSPTRP00000041774	ENSPTRP00000019515	AMBN isoform 1.	Kallikrein related peptidase 4; Belongs to the peptidase S1 family.	0.734
AMBN	MMP20	ENSPTRP00000041774	ENSPTRP00000007255	AMBN isoform 1.	Matrix metallopeptidase 20.	0.834
AMBN	ODAM	ENSPTRP00000041774	ENSPTRP00000027726	AMBN isoform 1.	Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family.	0.718
AMTN	AMBN	ENSPTRP00000027734	ENSPTRP00000041774	AMTN isoform 1.	AMBN isoform 1.	0.944
AMTN	DMP1	ENSPTRP00000027734	ENSPTRP00000027932	AMTN isoform 1.	Dentin matrix acidic phosphoprotein 1.	0.845
AMTN	ENAM	ENSPTRP00000027734	ENSPTRP00000082702	AMTN isoform 1.	ENAM isoform 1.	0.958
AMTN	KLK4	ENSPTRP00000027734	ENSPTRP00000019515	AMTN isoform 1.	Kallikrein related peptidase 4; Belongs to the peptidase S1 family.	0.743
AMTN	MMP20	ENSPTRP00000027734	ENSPTRP00000007255	AMTN isoform 1.	Matrix metallopeptidase 20.	0.733
AMTN	ODAM	ENSPTRP00000027734	ENSPTRP00000027726	AMTN isoform 1.	Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family.	0.909
CER1	LEFTY1	ENSPTRP00000035539	ENSPTRP00000079434	CER1 isoform 1.	Left-right determination factor.	0.558
CER1	WNT10A	ENSPTRP00000035539	ENSPTRP00000022097	CER1 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.900
CHRD	DSPP	ENSPTRP00000086110	ENSPTRP00000027930	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	DSPP isoform 1.	0.475
CHRD	LEFTY1	ENSPTRP00000086110	ENSPTRP00000079434	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Left-right determination factor.	0.417
CHRD	OTX2	ENSPTRP00000086110	ENSPTRP00000010823	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Orthodenticle homeobox 2.	0.496
CHRD	SHH	ENSPTRP00000086110	ENSPTRP00000075730	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.409
DMP1	AMBN	ENSPTRP00000027932	ENSPTRP00000041774	Dentin matrix acidic phosphoprotein 1.	AMBN isoform 1.	0.718