STRINGSTRING
NES NES MMP20 MMP20 PAX9 PAX9 OTX2 OTX2 KLK4 KLK4 SIX3 SIX3 WNT10A WNT10A ODAM ODAM AMTN AMTN DSPP DSPP DMP1 DMP1 EYA1 EYA1 CER1 CER1 AMBN AMBN SOX10 SOX10 SOX2 SOX2 PPP4R1 PPP4R1 FOXD3 FOXD3 FOXE3 FOXE3 DEFB113 DEFB113 MSX1 MSX1 KCNMB2 KCNMB2 SOX1 SOX1 COX1 COX1 PRPF3 PRPF3 NET1 NET1 PAX6 PAX6 ABCB6 ABCB6 ZIC1 ZIC1 RNF217 RNF217 SLC4A7 SLC4A7 ENSPTRP00000074429 ENSPTRP00000074429 SHH SHH CGN CGN PDLIM7 PDLIM7 LEFTY1 LEFTY1 CNKSR1 CNKSR1 ENAM ENAM CHRD CHRD SOX11 SOX11 PAX2 PAX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
PAX9Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. (347 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
SIX3SIX homeobox 3. (331 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
ODAMOdontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface; Belongs to the ODAM family. (279 aa)
AMTNAMTN isoform 1. (209 aa)
DSPPDSPP isoform 1. (1292 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (513 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
CER1CER1 isoform 1. (267 aa)
AMBNAMBN isoform 1. (447 aa)
SOX10SRY-box transcription factor 10. (466 aa)
SOX2SRY-box transcription factor 2. (319 aa)
PPP4R1Protein phosphatase 4, regulatory subunit 1. (950 aa)
FOXD3FOXD3 isoform 1. (478 aa)
FOXE3FOXE3 isoform 1. (319 aa)
DEFB113Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (263 aa)
SOX1SOX1 isoform 1. (391 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (513 aa)
PRPF3U4/U6 small nuclear ribonucleoprotein Prp3. (683 aa)
NET1Neuroepithelial cell transforming 1. (603 aa)
PAX6PAX6 isoform 13. (436 aa)
ABCB6ATP-binding cassette, sub-family B (MDR/TAP), member 6. (854 aa)
ZIC1Zic family member 1. (447 aa)
RNF217RBR-type E3 ubiquitin transferase. (542 aa)
SLC4A7Anion exchange protein. (1259 aa)
ENSPTRP00000074429annotation not available (586 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CGNCGN isoform 6. (1210 aa)
PDLIM7PDZ and LIM domain 7 (Enigma). (459 aa)
LEFTY1Left-right determination factor. (366 aa)
CNKSR1CNKSR1 isoform 5. (720 aa)
ENAMENAM isoform 1. (1142 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
SOX11Transcription factor SOX. (441 aa)
PAX2PAX2 isoform 1. (417 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (20%) [HD]