STRINGSTRING
TMEM165 TMEM165 PITHD1 PITHD1 CMPK1 CMPK1 ELAVL4 ELAVL4 SCP2 SCP2 GPR61 GPR61 NPL NPL KISS1 KISS1 MFSD4A MFSD4A AGT AGT ARV1 ARV1 PRLHR PRLHR SCYL1 SCYL1 GAL GAL CCDC82 CCDC82 SIAE SIAE LIMA1 LIMA1 PMCH PMCH CRY1 CRY1 PEBP1 PEBP1 CRYL1 CRYL1 SAP18 SAP18 ESD ESD PCID2-2 PCID2-2 ACTR10 ACTR10 VTI1B VTI1B EMC7 EMC7 CCNDBP1 CCNDBP1 NMB NMB AGRP AGRP KIAA0753 KIAA0753 GABARAP GABARAP PEMT PEMT WSB1 WSB1 RPL19 RPL19 NR1D1 NR1D1 HCRT HCRT PRDX2 PRDX2 NDUFB7 NDUFB7 RABAC1 RABAC1 RPL13A RPL13A RCN3 RCN3 SF3B6 SF3B6 HADHB HADHB SLC5A7 SLC5A7 DPP10 DPP10 INSIG2 INSIG2 ZC3H15 ZC3H15 CAB39 CAB39 OXT OXT AVP AVP RBM11 RBM11 SULT4A1 SULT4A1 OXTR OXTR UBE2E1 UBE2E1 ATP6V1A ATP6V1A POGLUT1 POGLUT1 IFT80 IFT80 CLOCK CLOCK ENOPH1 ENOPH1 BDH2 BDH2 ENSPTRP00000028285 ENSPTRP00000028285 MATR3 MATR3 ERGIC1 ERGIC1 NSG2 NSG2 LSM2 LSM2 MCHR2 MCHR2 ECHDC1 ECHDC1 EPM2A EPM2A ESR1 ESR1 EIF2AK1 EIF2AK1 NPY NPY FAM131B FAM131B GNRH1 GNRH1 CHRNA2 CHRNA2 CRH CRH NR5A1 NR5A1 EIF1AX EIF1AX ATP6AP2 ATP6AP2 BEX1 BEX1 DCAF12L2 DCAF12L2 EIF1AY EIF1AY DCAF12L1 DCAF12L1 PER3 PER3 GPR150 GPR150 TMEM241 TMEM241 ATXN10 ATXN10 POMC POMC KCNF1 KCNF1 NPBWR1 NPBWR1 OPN5 OPN5 TMEM126B TMEM126B PLD4 PLD4 ENSPTRP00000061516 ENSPTRP00000061516 ENSPTRP00000061866 ENSPTRP00000061866 RAPGEF4 RAPGEF4 LOC465300 LOC465300 GFAP GFAP PGM1 PGM1 ENSPTRP00000063783 ENSPTRP00000063783 TAGLN3 TAGLN3 CRHR1 CRHR1 LOC452746 LOC452746 TDRKH TDRKH NPBWR2 NPBWR2 LOC739722 LOC739722 ARNTL ARNTL ASTE1 ASTE1 LOC470419 LOC470419 GDF1 GDF1 ENSPTRP00000066724 ENSPTRP00000066724 TAFA5 TAFA5 SCRN1 SCRN1 TMEM125 TMEM125 CHTOP CHTOP NADK NADK NPAS2 NPAS2 KISS1R KISS1R KLHL2 KLHL2 PER2 PER2 INO80C INO80C ENSPTRP00000071872 ENSPTRP00000071872 SLC11A2 SLC11A2 REPS2 REPS2 TPK1 TPK1 GON7 GON7 EIF2AK1-2 EIF2AK1-2 SLC38A1 SLC38A1 HP1BP3 HP1BP3 LOC101059334 LOC101059334 ENSPTRP00000077488 ENSPTRP00000077488 ATP6V1H ATP6V1H CRY2 CRY2 FOS FOS REM2 REM2 UIMC1 UIMC1 OPN4 OPN4 MSRA MSRA PPP2R2B PPP2R2B LHB LHB ENSPTRP00000079806 ENSPTRP00000079806 TTR TTR NDUFAF2 NDUFAF2 SLC25A37 SLC25A37 STOM STOM LOC454185 LOC454185 PCID2 PCID2 DBNDD2 DBNDD2 NXPH3 NXPH3 CRHR1-2 CRHR1-2 ENSPTRP00000087048 ENSPTRP00000087048 PMCHL1 PMCHL1 ENSPTRP00000087474 ENSPTRP00000087474 ENSPTRP00000087701 ENSPTRP00000087701 KLF12 KLF12 ENSPTRP00000088432 ENSPTRP00000088432 PSMB5 PSMB5 CRHR2 CRHR2 PRUNE2 PRUNE2 ENSPTRP00000089382 ENSPTRP00000089382 MRPL57 MRPL57 ACOT13 ACOT13 NDUFB6 NDUFB6 TAC3 TAC3 COX11 COX11 DCAF12L2-2 DCAF12L2-2 LSM4 LSM4 MBP MBP LOC743136 LOC743136 ENSPTRP00000093851 ENSPTRP00000093851 ENSPTRP00000093934 ENSPTRP00000093934
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM165GDT1 family protein. (324 aa)
PITHD1PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (212 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
GPR61G protein-coupled receptor 61; Belongs to the G-protein coupled receptor 1 family. (451 aa)
NPLN-acetylneuraminate pyruvate lyase (Dihydrodipicolinate synthase); Belongs to the DapA family. (320 aa)
KISS1KISS1 isoform 2. (138 aa)
MFSD4AMajor facilitator superfamily domain containing 4A. (514 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
SCYL1SCY1 like pseudokinase 1. (808 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
CCDC82Coiled-coil domain containing 82. (544 aa)
SIAESialic acid acetylesterase. (523 aa)
LIMA1LIM domain and actin binding 1. (735 aa)
PMCHPro-MCH. (165 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
PEBP1Phosphatidylethanolamine binding protein 1. (187 aa)
CRYL1Crystallin, lambda 1. (319 aa)
SAP18Sin3A associated protein 18. (172 aa)
ESDS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
PCID2-2PCI domain-containing protein 2. (399 aa)
ACTR10Actin-related protein 10 homolog; Belongs to the actin family. (417 aa)
VTI1BVesicle transport through interaction with t-SNAREs homolog 1B. (232 aa)
EMC7ER membrane protein complex subunit 7. (242 aa)
CCNDBP1Cyclin D-type binding-protein 1. (360 aa)
NMBNMB isoform 1. (154 aa)
AGRPAgouti related neuropeptide. (132 aa)
KIAA0753KIAA0753 isoform 1. (967 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (236 aa)
WSB1WD repeat and SOCS box containing 1. (421 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (200 aa)
NR1D1Nuclear receptor subfamily 1, group D, member 1. (614 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
PRDX2PRDX2 isoform 1. (198 aa)
NDUFB7NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (137 aa)
RABAC1PRA1 family protein. (185 aa)
RPL13ARPL13A isoform 2; Belongs to the universal ribosomal protein uL13 family. (203 aa)
RCN3Reticulocalbin 3, EF-hand calcium binding domain. (336 aa)
SF3B6Splicing factor 3B, 14 kDa subunit. (125 aa)
HADHBTrifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] (475 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
DPP10DPP10 isoform 3; Belongs to the peptidase S9B family. (881 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
ZC3H15Zinc finger CCCH-type containing 15. (426 aa)
CAB39Calcium binding protein 39. (341 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
RBM11RNA binding motif protein 11. (281 aa)
SULT4A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (284 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
UBE2E1Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (202 aa)
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A. (618 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
CLOCKClock circadian regulator. (847 aa)
ENOPH1Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa)
BDH23-hydroxybutyrate dehydrogenase, type 2. (245 aa)
ENSPTRP00000028285annotation not available (77 aa)
MATR3MATR3 isoform 14. (895 aa)
ERGIC1Endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1. (290 aa)
NSG2Neuronal vesicle trafficking associated 2. (171 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
MCHR2Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
ECHDC1Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (307 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1. (630 aa)
NPYNeuropeptide Y. (97 aa)
FAM131BFamily with sequence similarity 131, member B. (360 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)
CHRNA2Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (529 aa)
CRHCorticotropin releasing hormone. (196 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
EIF1AXEukaryotic translation initiation factor 1A X-linked. (124 aa)
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 2. (350 aa)
BEX1Brain expressed X-linked 1. (125 aa)
DCAF12L2DCAF12L2 isoform 1. (463 aa)
EIF1AYEukaryotic translation initiation factor 1A, Y-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity); Belongs to the eIF-1A family. (144 aa)
DCAF12L1DDB1 and CUL4 associated factor 12 like 1. (463 aa)
PER3Period circadian regulator 3. (1191 aa)
GPR150G protein-coupled receptor 150. (435 aa)
TMEM241Chromosome 18 open reading frame 45. (296 aa)
ATXN10ATXN10 isoform 1. (475 aa)
POMCProopiomelanocortin. (268 aa)
KCNF1KCNF1 isoform 1; Belongs to the potassium channel family. (506 aa)
NPBWR1Neuropeptides B and W receptor 1; Belongs to the G-protein coupled receptor 1 family. (328 aa)
OPN5OPN5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
TMEM126BTMEM126B isoform 2. (230 aa)
PLD4Phospholipase D family member 4. (513 aa)
ENSPTRP00000061516annotation not available (182 aa)
ENSPTRP00000061866annotation not available (267 aa)
RAPGEF4RAPGEF4 isoform 2. (1011 aa)
LOC46530060S ribosomal protein L13a pseudogene. (203 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
PGM1Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (580 aa)
ENSPTRP00000063783annotation not available (184 aa)
TAGLN3Transgelin; Belongs to the calponin family. (272 aa)
CRHR1Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. (415 aa)
LOC45274660S ribosomal protein L13a pseudogene. (203 aa)
TDRKHTudor and KH domain containing. (605 aa)
NPBWR2Neuropeptides B and W receptor 2; Belongs to the G-protein coupled receptor 1 family. (333 aa)
LOC739722NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 pseudogene. (156 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like. (628 aa)
ASTE1Asteroid homolog 1. (704 aa)
LOC470419Phosphatidylethanolamine-binding protein 1 pseudogene. (168 aa)
GDF1CERS1 isoform 2. (372 aa)
ENSPTRP00000066724annotation not available (166 aa)
TAFA5FAM19A5 isoform 1. (181 aa)
SCRN1SCRN1 isoform 1. (434 aa)
TMEM125Transmembrane protein 125. (219 aa)
CHTOPChromatin target of PRMT1. (277 aa)
NADKNADK isoform 3. (591 aa)
NPAS2Neuronal PAS domain protein 2. (827 aa)
KISS1RKISS1R isoform 1. (401 aa)
KLHL2Kelch like family member 2. (597 aa)
PER2Period circadian regulator 2. (1255 aa)
INO80CINO80 complex subunit C. (228 aa)
ENSPTRP00000071872annotation not available (122 aa)
SLC11A2SLC11A2 isoform 1. (590 aa)
REPS2RALBP1 associated Eps domain containing 2. (659 aa)
TPK1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa)
GON7Chromosome 14 open reading frame 142. (107 aa)
EIF2AK1-2Eukaryotic translation initiation factor 2 alpha kinase 1. (647 aa)
SLC38A1Solute carrier family 38 member 1. (503 aa)
HP1BP3Heterochromatin protein 1, binding protein 3. (553 aa)
LOC10105933460S ribosomal protein L13a pseudogene. (199 aa)
ENSPTRP00000077488annotation not available (256 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
UIMC1Ubiquitin interaction motif containing 1. (722 aa)
OPN4OPN4 isoform 3. (495 aa)
MSRAMethionine sulfoxide reductase A. (236 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (157 aa)
ENSPTRP00000079806annotation not available (146 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family. (163 aa)
NDUFAF2NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, assembly factor 2. (169 aa)
SLC25A37Solute carrier family 25, member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
STOMSTOM isoform 3. (288 aa)
LOC45418560S ribosomal protein L13a pseudogene. (142 aa)
PCID2PCI domain containing 2. (398 aa)
DBNDD2Dysbindin domain-containing protein 2 isoform X5. (263 aa)
NXPH3NXPH3 isoform 2. (354 aa)
CRHR1-2Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. (444 aa)
ENSPTRP00000087048annotation not available (82 aa)
PMCHL1Pro-MCH variant; Belongs to the melanin-concentrating hormone family. (82 aa)
ENSPTRP00000087474annotation not available (168 aa)
ENSPTRP00000087701annotation not available (453 aa)
KLF12Kruppel-like factor 12. (404 aa)
ENSPTRP00000088432annotation not available (360 aa)
PSMB5Proteasome subunit beta. (263 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (438 aa)
PRUNE2PRUNE2 isoform 4. (3088 aa)
ENSPTRP00000089382annotation not available (111 aa)
MRPL57Mitochondrial ribosomal protein L57. (102 aa)
ACOT13Acyl-CoA thioesterase 13. (140 aa)
NDUFB6NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
TAC3TAC3 isoform 1. (121 aa)
COX11COX11 cytochrome c oxidase assembly homolog. (276 aa)
DCAF12L2-2DDB1 and CUL4 associated factor 12 like 2. (463 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (238 aa)
MBPMyelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). (304 aa)
LOC74313660S ribosomal protein L19 pseudogene. (194 aa)
ENSPTRP00000093851annotation not available (227 aa)
ENSPTRP00000093934annotation not available (178 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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