20 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX2	SRY-box transcription factor 2. (319 aa)
	ENSPTRP00000090372	annotation not available (274 aa)
	POU5F1B	POU domain protein. (359 aa)
	FOXA2	FOXA2 isoform 1. (464 aa)
	ENSPTRP00000086503	annotation not available (166 aa)
	ENSPTRP00000083127	annotation not available (244 aa)
	ENSPTRP00000082402	annotation not available (277 aa)
	BMP4-2	Bone morphogenetic protein 4. (408 aa)
	GATA4	GATA binding protein 4. (443 aa)
	ENSPTRP00000073411	annotation not available (299 aa)
	ENSPTRP00000071338	annotation not available (290 aa)
	ENSPTRP00000068971	annotation not available (348 aa)
	COX1	Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (513 aa)
	DEFB113	Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (398 aa)
	SOX17	SOX17 isoform 1. (416 aa)
	POU5F1	POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). (360 aa)
	GATA6	GATA binding protein 6. (594 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	NANOG	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	GATA4	ENSPTRP00000010780	ENSPTRP00000075865	Bone morphogenetic protein 4.	GATA binding protein 4.	0.781
BMP4	GATA6	ENSPTRP00000010780	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4	NANOG	ENSPTRP00000010780	ENSPTRP00000007892	Bone morphogenetic protein 4.	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...]	0.554
BMP4	SOX17	ENSPTRP00000010780	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523
BMP4	SOX2	ENSPTRP00000010780	ENSPTRP00000046752	Bone morphogenetic protein 4.	SRY-box transcription factor 2.	0.566
BMP4-2	GATA4	ENSPTRP00000080656	ENSPTRP00000075865	Bone morphogenetic protein 4.	GATA binding protein 4.	0.781
BMP4-2	GATA6	ENSPTRP00000080656	ENSPTRP00000016858	Bone morphogenetic protein 4.	GATA binding protein 6.	0.546
BMP4-2	NANOG	ENSPTRP00000080656	ENSPTRP00000007892	Bone morphogenetic protein 4.	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...]	0.554
BMP4-2	SOX17	ENSPTRP00000080656	ENSPTRP00000034688	Bone morphogenetic protein 4.	SOX17 isoform 1.	0.523
BMP4-2	SOX2	ENSPTRP00000080656	ENSPTRP00000046752	Bone morphogenetic protein 4.	SRY-box transcription factor 2.	0.566
ENSPTRP00000068971	ENSPTRP00000071338	ENSPTRP00000068971	ENSPTRP00000071338	annotation not available	annotation not available	0.711
ENSPTRP00000068971	ENSPTRP00000073411	ENSPTRP00000068971	ENSPTRP00000073411	annotation not available	annotation not available	0.711
ENSPTRP00000068971	ENSPTRP00000083127	ENSPTRP00000068971	ENSPTRP00000083127	annotation not available	annotation not available	0.711
ENSPTRP00000068971	ENSPTRP00000086503	ENSPTRP00000068971	ENSPTRP00000086503	annotation not available	annotation not available	0.642
ENSPTRP00000068971	ENSPTRP00000090372	ENSPTRP00000068971	ENSPTRP00000090372	annotation not available	annotation not available	0.711
ENSPTRP00000068971	FOXA2	ENSPTRP00000068971	ENSPTRP00000090114	annotation not available	FOXA2 isoform 1.	0.473
ENSPTRP00000068971	NANOG	ENSPTRP00000068971	ENSPTRP00000007892	annotation not available	Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...]	0.927
ENSPTRP00000068971	SOX17	ENSPTRP00000068971	ENSPTRP00000034688	annotation not available	SOX17 isoform 1.	0.588
ENSPTRP00000068971	SOX2	ENSPTRP00000068971	ENSPTRP00000046752	annotation not available	SRY-box transcription factor 2.	0.982
ENSPTRP00000071338	ENSPTRP00000068971	ENSPTRP00000071338	ENSPTRP00000068971	annotation not available	annotation not available	0.711