STRINGSTRING
SCN10A SCN10A SMC3 SMC3 HRH3 HRH3 SLC17A6 SLC17A6 NUMB NUMB TBR1 TBR1 ACHE ACHE TRPA1 TRPA1 DCTN4 DCTN4 CNGA4 CNGA4 HRH1 HRH1 OR10K2 OR10K2 POMC POMC NOL4L NOL4L FUS FUS CHAT CHAT ATXN1 ATXN1 BDNF BDNF KCNE5 KCNE5 CDS1 CDS1 GFAP GFAP ENSPTRP00000063247 ENSPTRP00000063247 TRPM1 TRPM1 HTT HTT DRD1 DRD1 SST SST DCX DCX DRD2 DRD2 NGF NGF CHD1L CHD1L ENSPTRP00000070902 ENSPTRP00000070902 CAPN15 CAPN15 CALB2 CALB2 MCM8 MCM8 ENSPTRP00000073803 ENSPTRP00000073803 SUFU SUFU PVALB PVALB DZANK1 DZANK1 SHH SHH CK820_G0034985 CK820_G0034985 RIT2 RIT2 WNK1 WNK1 ATP2C1 ATP2C1 MID1 MID1 CNGA2-2 CNGA2-2 TPH1 TPH1 FOS FOS PARK7 PARK7 OPN4 OPN4 GRID2 GRID2 CACNA1A CACNA1A SLC1A6 SLC1A6 KCNK3 KCNK3 TAC1 TAC1 SNTG1 SNTG1 TPH2 TPH2 ENSPTRP00000088792 ENSPTRP00000088792 NR4A2 NR4A2 LOC461829 LOC461829 SNCA SNCA GRIA1 GRIA1 GAD2 GAD2 KCNK9 KCNK9 APP APP RBFOX3 RBFOX3 TARDBP TARDBP PINK1 PINK1 POU4F1 POU4F1 SLC27A3 SLC27A3 OR10K1 OR10K1 SLC18A3 SLC18A3 TRIM8 TRIM8 TH TH GRIN2B GRIN2B LRRK2 LRRK2 SAV1 SAV1 FAM161B FAM161B VSX2 VSX2 HDC HDC IGDCC3 IGDCC3 AGRP AGRP FCSK FCSK TRPV1 TRPV1 DLG4 DLG4 RCVRN RCVRN UNC119 UNC119 SLC6A4 SLC6A4 PPP1R1B PPP1R1B PNMT PNMT HCRT HCRT PRKCA PRKCA LGALS4 LGALS4 SNTG2 SNTG2 PTRHD1 PTRHD1 ADCY3 ADCY3 GAD1 GAD1 PARD3B PARD3B OXT OXT SLC32A1 SLC32A1 ZNFX1 ZNFX1 SOD1 SOD1 RHO RHO BCHE BCHE XXYLT1 XXYLT1 ENSPTRP00000028285 ENSPTRP00000028285 POU4F2 POU4F2 TLR3 TLR3 SLC6A3 SLC6A3 ISL1 ISL1 HTR1A HTR1A GRM6 GRM6 BAG2 BAG2 HTR1B HTR1B GJA10 GJA10 PRKN PRKN NPY NPY CALB1 CALB1 C9H9orf72 C9H9orf72 DBH DBH DACH2 DACH2 CNGA2 CNGA2 RBM23 RBM23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
HRH3Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
TBR1T-box brain transcription factor 1. (682 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
DCTN4Dynactin subunit 4. (467 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
HRH1Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (487 aa)
OR10K2Olfactory receptor family 10 subfamily K member 2. (312 aa)
POMCProopiomelanocortin. (268 aa)
NOL4LNucleolar protein 4 like. (680 aa)
FUSFUS isoform 7. (526 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (748 aa)
ATXN1ATXN1 isoform 2. (827 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (461 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (505 aa)
ENSPTRP00000063247annotation not available (271 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1642 aa)
HTTHTT isoform 1. (3131 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
SSTSST isoform 1. (116 aa)
DCXDCX isoform 5. (420 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
CHD1LChromodomain helicase DNA binding protein 1-like. (925 aa)
ENSPTRP00000070902annotation not available (168 aa)
CAPN15Small optic lobes homolog; Belongs to the peptidase C2 family. (1139 aa)
CALB2CALB2 isoform 1. (271 aa)
MCM8Minichromosome maintenance complex component 8; Belongs to the MCM family. (879 aa)
ENSPTRP00000073803annotation not available (414 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
PVALBPVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
DZANK1DZANK1 isoform 3. (777 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
CK820_G0034985TARDBP isoform 25. (246 aa)
RIT2Ras like without CAAX 2. (217 aa)
WNK1WNK1 isoform 4. (2833 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (983 aa)
MID1MID1 isoform 1. (663 aa)
CNGA2-2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PARK7PARK7 isoform 1. (189 aa)
OPN4OPN4 isoform 3. (495 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2504 aa)
SLC1A6Amino acid transporter. (564 aa)
KCNK3Potassium channel subfamily K member. (394 aa)
TAC1TAC1 isoform 1. (134 aa)
SNTG1Syntrophin gamma 1. (517 aa)
TPH2Tryptophan hydroxylase 2. (490 aa)
ENSPTRP00000088792annotation not available (228 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
LOC461829Survival of motor neuron 1, telomeric. (297 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (140 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (916 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (771 aa)
RBFOX3RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (373 aa)
TARDBPTAR DNA binding protein. (414 aa)
PINK1PTEN induced putative kinase 1. (581 aa)
POU4F1POU domain protein. (350 aa)
SLC27A3SLC27A3 isoform 3. (811 aa)
OR10K1Olfactory receptor family 10 subfamily K member 1. (313 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
TRIM8Tripartite motif containing 8. (551 aa)
THTyrosine hydroxylase. (528 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
LRRK2Leucine-rich repeat kinase 2. (2527 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FAM161BFAM161B isoform 2. (709 aa)
VSX2VSX2 isoform 1. (380 aa)
HDCHistidine decarboxylase. (662 aa)
IGDCC3Immunoglobulin superfamily DCC subclass member 3. (814 aa)
AGRPAgouti related neuropeptide. (132 aa)
FCSKFUK isoform 2. (1084 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
RCVRNRCVRN isoform 1. (200 aa)
UNC119Unc-119 lipid binding chaperone. (240 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
PNMTPhenylethanolamine N-methyltransferase. (282 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LGALS4Galectin. (323 aa)
SNTG2SNTG2 isoform 3. (539 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
GAD1Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (594 aa)
PARD3BPartitioning defective 3 homolog B isoform X1. (1205 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
SLC32A1Solute carrier family 32 member 1. (525 aa)
ZNFX1Zinc finger, NFX1-type containing 1. (1918 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
RHORhodopsin. (348 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (643 aa)
XXYLT1Chromosome 3 open reading frame 21. (393 aa)
ENSPTRP00000028285annotation not available (77 aa)
POU4F2POU domain protein. (406 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HTR1A5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] (422 aa)
GRM6GRM6 isoform 2. (879 aa)
BAG2BCL2-associated athanogene 2. (211 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (390 aa)
GJA10Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (492 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
NPYNeuropeptide Y. (97 aa)
CALB1CALB1 isoform 3. (261 aa)
C9H9orf72Chromosome 9 open reading frame 72. (481 aa)
DBHDopamine beta-hydroxylase. (617 aa)
DACH2Dachshund family transcription factor 2. (599 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
RBM23RBM23 isoform 1. (442 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.