13 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	COL2A1	Collagen type II alpha 1 chain. (1487 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	ENSPTRP00000063462	annotation not available (106 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
	NKX2-3	NKX2-3 isoform 1. (366 aa)
	ENSPTRP00000080333	annotation not available (111 aa)
	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (116 aa)
	SPIRE2	SPIRE2 isoform 1. (643 aa)
	NDUFA5-2	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5. (111 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	FOXI1	FOXI1 isoform 2. (378 aa)
	COL10A1	Collagen type X alpha 1 chain. (680 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL10A1	COL2A1	ENSPTRP00000031636	ENSPTRP00000041995	Collagen type X alpha 1 chain.	Collagen type II alpha 1 chain.	0.570
COL10A1	IHH	ENSPTRP00000031636	ENSPTRP00000022106	Collagen type X alpha 1 chain.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.604
COL10A1	RUNX2	ENSPTRP00000031636	ENSPTRP00000065999	Collagen type X alpha 1 chain.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.755
COL10A1	SOX9	ENSPTRP00000031636	ENSPTRP00000016293	Collagen type X alpha 1 chain.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.688
COL2A1	COL10A1	ENSPTRP00000041995	ENSPTRP00000031636	Collagen type II alpha 1 chain.	Collagen type X alpha 1 chain.	0.570
COL2A1	IHH	ENSPTRP00000041995	ENSPTRP00000022106	Collagen type II alpha 1 chain.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.577
COL2A1	RUNX2	ENSPTRP00000041995	ENSPTRP00000065999	Collagen type II alpha 1 chain.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.685
COL2A1	SOX9	ENSPTRP00000041995	ENSPTRP00000016293	Collagen type II alpha 1 chain.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.819
ENSPTRP00000063462	ENSPTRP00000080333	ENSPTRP00000063462	ENSPTRP00000080333	annotation not available	annotation not available	0.550
ENSPTRP00000063462	NDUFA5	ENSPTRP00000063462	ENSPTRP00000083278	annotation not available	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.545
ENSPTRP00000063462	NDUFA5-2	ENSPTRP00000063462	ENSPTRP00000091047	annotation not available	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5.	0.549
ENSPTRP00000080333	ENSPTRP00000063462	ENSPTRP00000080333	ENSPTRP00000063462	annotation not available	annotation not available	0.550
ENSPTRP00000080333	NDUFA5	ENSPTRP00000080333	ENSPTRP00000083278	annotation not available	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.547
ENSPTRP00000080333	NDUFA5-2	ENSPTRP00000080333	ENSPTRP00000091047	annotation not available	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5.	0.551
IHH	COL10A1	ENSPTRP00000022106	ENSPTRP00000031636	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Collagen type X alpha 1 chain.	0.604
IHH	COL2A1	ENSPTRP00000022106	ENSPTRP00000041995	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Collagen type II alpha 1 chain.	0.577
IHH	RUNX2	ENSPTRP00000022106	ENSPTRP00000065999	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.878
IHH	SOX9	ENSPTRP00000022106	ENSPTRP00000016293	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.697
NDUFA5	ENSPTRP00000063462	ENSPTRP00000083278	ENSPTRP00000063462	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	annotation not available	0.545
NDUFA5	ENSPTRP00000080333	ENSPTRP00000083278	ENSPTRP00000080333	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	annotation not available	0.547