STRINGSTRING
ENSPTRP00000071338 ENSPTRP00000071338 ENSPTRP00000073411 ENSPTRP00000073411 BMP4-2 BMP4-2 ENSPTRP00000082402 ENSPTRP00000082402 ENSPTRP00000083127 ENSPTRP00000083127 POU5F1B POU5F1B ENSPTRP00000086503 ENSPTRP00000086503 ENSPTRP00000090372 ENSPTRP00000090372 NANOG NANOG BMP4 BMP4 POU5F1 POU5F1 KLF4 KLF4 SOX2 SOX2 PAX6 PAX6 FGF2 FGF2 ENSPTRP00000068971 ENSPTRP00000068971
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000071338annotation not available (290 aa)
ENSPTRP00000073411annotation not available (299 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ENSPTRP00000082402annotation not available (277 aa)
ENSPTRP00000083127annotation not available (244 aa)
POU5F1BPOU domain protein. (359 aa)
ENSPTRP00000086503annotation not available (166 aa)
ENSPTRP00000090372annotation not available (274 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). (360 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
SOX2SRY-box transcription factor 2. (319 aa)
PAX6PAX6 isoform 13. (436 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
ENSPTRP00000068971annotation not available (348 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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