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MTHFR MTHFR CTH CTH PHGDH PHGDH SELENBP1 SELENBP1 IBA57 IBA57 THNSL1 THNSL1 MAT1A MAT1A LIPT2 LIPT2 ALDH1L2 ALDH1L2 SDS SDS SDSL SDSL MTHFD1 MTHFD1 MTFMT MTFMT TAT TAT SRR SRR PIPOX PIPOX TYMS TYMS ILVBL ILVBL MTHFD2 MTHFD2 MAT2A MAT2A THNSL2 THNSL2 LIPT1 LIPT1 DIDO1 DIDO1 CBS CBS ALAS1 ALAS1 LIAS LIAS PPAT PPAT DMGDH DMGDH BHMT BHMT DHFR DHFR MAT2B MAT2B GNMT GNMT MTHFD1L MTHFD1L PSPH PSPH GGH GGH RIDA RIDA PSAT1 PSAT1 SARDH SARDH GART GART GCAT GCAT MTR MTR HMGCLL1 HMGCLL1 BCAT1 BCAT1 SHMT2 SHMT2 ENSPTRP00000063651 ENSPTRP00000063651 ENSPTRP00000064422 ENSPTRP00000064422 ENSPTRP00000065447 ENSPTRP00000065447 ENSPTRP00000065677 ENSPTRP00000065677 LOC465383 LOC465383 AHCYL1 AHCYL1 ENSPTRP00000066929 ENSPTRP00000066929 PSPH-2 PSPH-2 LOC465383-2 LOC465383-2 FTCD FTCD MTHFD2L MTHFD2L PDPR PDPR LOC742399 LOC742399 AHCYL2 AHCYL2 SHMT1 SHMT1 ALAS2 ALAS2 LOC463989 LOC463989 ENSPTRP00000077512 ENSPTRP00000077512 ENSPTRP00000081875 ENSPTRP00000081875 ENSPTRP00000082047 ENSPTRP00000082047 ENSPTRP00000082302 ENSPTRP00000082302 LOC736372 LOC736372 GART-2 GART-2 DAO DAO ENSPTRP00000084905 ENSPTRP00000084905 ALDH1L1 ALDH1L1 FPGS FPGS ENSPTRP00000086091 ENSPTRP00000086091 ENSPTRP00000086258 ENSPTRP00000086258 AHCY AHCY PAICS PAICS MTHFS MTHFS DHFR2 DHFR2 ENSPTRP00000092611 ENSPTRP00000092611 ENSPTRP00000092796 ENSPTRP00000092796
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa)
CTHCystathionase (Cystathionine gamma-lyase). (405 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (573 aa)
SELENBP1Selenium binding protein 1. (514 aa)
IBA57IBA57, iron-sulfur cluster assembly homolog. (356 aa)
THNSL1Threonine synthase-like 1. (743 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (231 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
SDSSerine dehydratase. (328 aa)
SDSLSerine dehydratase-like. (329 aa)
MTHFD1MTHFD1 isoform 1. (1020 aa)
MTFMTMitochondrial methionyl-tRNA formyltransferase. (389 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
SRRSerine racemase. (340 aa)
PIPOXPIPOX isoform 6. (390 aa)
TYMSThymidylate synthetase. (313 aa)
ILVBLIlvB (Bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (632 aa)
MTHFD2MTHFD2 isoform 1. (350 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
THNSL2Threonine synthase-like 2. (484 aa)
LIPT1Lipoyltransferase 1. (373 aa)
DIDO1Death inducer-obliterator 1. (2237 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
ALAS15-aminolevulinate synthase. (640 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
DMGDHDimethylglycine dehydrogenase. (866 aa)
BHMTBHMT isoform 1; Involved in the regulation of homocysteine metabolism. (470 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (334 aa)
GNMTGlycine N-methyltransferase. (295 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. (805 aa)
PSPHPhosphoserine phosphatase. (225 aa)
GGHFolate gamma-glutamyl hydrolase. (318 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
PSAT1Phosphoserine aminotransferase. (370 aa)
SARDHSarcosine dehydrogenase. (918 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
GCATGlycine C-acetyltransferase. (445 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1267 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (370 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ENSPTRP00000063651annotation not available (369 aa)
ENSPTRP00000064422annotation not available (501 aa)
ENSPTRP00000065447annotation not available (354 aa)
ENSPTRP00000065677annotation not available (396 aa)
LOC465383Uncharacterized protein. (210 aa)
AHCYL1Adenosylhomocysteinase. (499 aa)
ENSPTRP00000066929annotation not available (132 aa)
PSPH-2Phosphoserine phosphatase. (225 aa)
LOC465383-2Uncharacterized protein. (72 aa)
FTCDFTCD isoform 4. (53 aa)
MTHFD2LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (347 aa)
PDPRPDPR isoform 5. (237 aa)
LOC742399Glycine cleavage system H protein, mitochondrial. (172 aa)
AHCYL2Adenosylhomocysteinase. (611 aa)
SHMT1Serine hydroxymethyltransferase 1. (483 aa)
ALAS25-aminolevulinate synthase. (587 aa)
LOC463989L-threonine 3-dehydrogenase, mitochondrial. (369 aa)
ENSPTRP00000077512annotation not available (168 aa)
ENSPTRP00000081875annotation not available (143 aa)
ENSPTRP00000082047annotation not available (353 aa)
ENSPTRP00000082302annotation not available (814 aa)
LOC736372Glycine dehydrogenase (decarboxylating), mitochondrial pseudogene. (980 aa)
GART-2annotation not available (1010 aa)
DAOD-amino acid oxidase. (347 aa)
ENSPTRP00000084905annotation not available (217 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (587 aa)
ENSPTRP00000086091annotation not available (385 aa)
ENSPTRP00000086258annotation not available (304 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (444 aa)
PAICSPAICS isoform 5. (432 aa)
MTHFS5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (232 aa)
DHFR2DHFR2 isoform 2. (186 aa)
ENSPTRP00000092611annotation not available (106 aa)
ENSPTRP00000092796annotation not available (139 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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