STRINGSTRING
PIK3CD PIK3CD TIE1 TIE1 SORT1 SORT1 BLNK BLNK FGFR2 FGFR2 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 CBL CBL FGF23 FGF23 KITLG KITLG SOCS2 SOCS2 FGF9 FGF9 FLT3 FLT3 FLT1 FLT1 KL KL SPRY2 SPRY2 IRS2 IRS2 SHC4 SHC4 FGF7 FGF7 LCTL LCTL CSK CSK IGF1R IGF1R SOCS1 SOCS1 IL34 IL34 PIK3R5 PIK3R5 STAT5A STAT5A SKAP1 SKAP1 NGFR NGFR GRB2 GRB2 SOCS6 SOCS6 SH3GL1 SH3GL1 VAV1 VAV1 PIK3R2 PIK3R2 FGF21 FGF21 NTF4 NTF4 FLT3LG FLT3LG CLEC11A CLEC11A KIDINS220 KIDINS220 IRS1 IRS1 ANGPT4 ANGPT4 SLA2 SLA2 PLCG1 PLCG1 SRMS SRMS PDGFB PDGFB GRAP2 GRAP2 CBLB CBLB PIK3CB PIK3CB FGFBP1 FGFBP1 KLB KLB PDGFRA PDGFRA KIT KIT KDR KDR FGF5 FGF5 DAPP1 DAPP1 EGF EGF GAB1 GAB1 VEGFC VEGFC FER FER FGF1 FGF1 ITK ITK LCP2 LCP2 FGFR4 FGFR4 FRS3 FRS3 KHDRBS2 KHDRBS2 ANGPT2 ANGPT2 DOK2 DOK2 PTK2B PTK2B PAG1 PAG1 VEGFD VEGFD BTK BTK KHDRBS3 KHDRBS3 FGF17 FGF17 MATK MATK PTPN1 PTPN1 SOS2 SOS2 PIK3CG PIK3CG FGF16 FGF16 FLT4 FLT4 GAB2 GAB2 LYN LYN CRKL CRKL VEGFB VEGFB EPOR EPOR SHC1 SHC1 SOS1 SOS1 LAT LAT PGF PGF PDGFA PDGFA BDNF BDNF PTPN11 PTPN11 SOCS5 SOCS5 MPIG6B MPIG6B ENSPTRP00000062007 ENSPTRP00000062007 PTK6 PTK6 INSR INSR SHC3 SHC3 PIK3R3 PIK3R3 FGF22 FGF22 FGFR1 FGFR1 ENSPTRP00000067174 ENSPTRP00000067174 FGF13 FGF13 TEC-2 TEC-2 FGF2 FGF2 IGF1 IGF1 EGFR EGFR ERBB2 ERBB2 TEK TEK CSF1 CSF1 NGF NGF PXN PXN INSRR INSRR TEC TEC PTPN11-2 PTPN11-2 ENSPTRP00000073371 ENSPTRP00000073371 SH2B2 SH2B2 P3R3URF P3R3URF RAPGEF1 RAPGEF1 ENSPTRP00000074763 ENSPTRP00000074763 CK820_G0050194 CK820_G0050194 SYK SYK FGF8 FGF8 STAP2 STAP2 ENSPTRP00000075918 ENSPTRP00000075918 GRAPL GRAPL PLCG2 PLCG2 SRC SRC PIK3R1 PIK3R1 ENSPTRP00000077211 ENSPTRP00000077211 NTRK2 NTRK2 FYN FYN PDGFD PDGFD TXK-2 TXK-2 BCAR1 BCAR1 IRS4 IRS4 PDGFRB PDGFRB FRS3-2 FRS3-2 CSF1R CSF1R ENSPTRP00000081537 ENSPTRP00000081537 PIK3R6 PIK3R6 SH3GL2 SH3GL2 JAK2 JAK2 SH3KBP1 SH3KBP1 CISH CISH CRK CRK NTRK1 NTRK1 PTK2 PTK2 VAV2 VAV2 PIK3CA PIK3CA CBLC CBLC FGF6 FGF6 ENSPTRP00000085461 ENSPTRP00000085461 NTRK3 NTRK3 TXK TXK FGF20 FGF20 SH3BP2 SH3BP2 ENSPTRP00000088414 ENSPTRP00000088414 STAT5B STAT5B FGFR3 FGFR3 ENSPTRP00000089450 ENSPTRP00000089450 FGF11 FGF11 NTF3 NTF3 VAV3 VAV3 FRS2 FRS2 FYB1 FYB1 YES1 YES1 PDGFC PDGFC STAT3 STAT3 FGF18 FGF18 ANGPT1 ANGPT1 SOCS3 SOCS3 ENSPTRP00000092364 ENSPTRP00000092364 SOCS7 SOCS7 VEGFA VEGFA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
SORT1SORT1 isoform 2. (831 aa)
BLNKBLNK isoform 2. (456 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
CBLCas-Br-M (Murine) ecotropic retroviral transforming sequence. (906 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
KLKL isoform 1. (1012 aa)
SPRY2Sprouty homolog 2. (338 aa)
IRS2IRS2 isoform 1. (1340 aa)
SHC4SHC adaptor protein 4. (630 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
LCTLLCTL isoform 6; Belongs to the glycosyl hydrolase 1 family. (567 aa)
CSKTyrosine-protein kinase. (450 aa)
IGF1RTyrosine-protein kinase receptor. (1364 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
IL34IL34 isoform 1. (242 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (882 aa)
STAT5ASignal transducer and activator of transcription. (783 aa)
SKAP1Src kinase associated phosphoprotein 1. (359 aa)
NGFRNerve growth factor receptor. (427 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R2Phosphoinositide-3-kinase, regulatory subunit 2 (Beta). (728 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
NTF4NTF4 isoform 1; Belongs to the NGF-beta family. (210 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (235 aa)
CLEC11AC-type lectin domain family 11, member A. (323 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ANGPT4ANGPT4 isoform 1. (503 aa)
SLA2Src like adaptor 2. (261 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
SRMSTyrosine-protein kinase. (447 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
CBLBCas-Br-M (Murine) ecotropic retroviral transforming sequence b. (982 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
KLBKLB isoform 1. (1044 aa)
PDGFRAT0011027 isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1102 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ITKTyrosine-protein kinase. (620 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
FRS3Fibroblast growth factor receptor substrate 3. (492 aa)
KHDRBS2KH RNA binding domain containing, signal transduction associated 2. (349 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
DOK2Docking protein 2. (412 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
BTKBTK isoform 2. (693 aa)
KHDRBS3KH domain containing, RNA binding, signal transduction associated 3. (334 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
MATKTyrosine-protein kinase. (508 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
GAB2GRB2-associated-binding protein 2. (676 aa)
LYNTyrosine-protein kinase. (512 aa)
CRKLV-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
LATLinker for activation of T cells. (268 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
PDGFAPDGFA isoform 4; Belongs to the PDGF/VEGF growth factor family. (227 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (329 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
MPIG6BMPIG6B isoform 11. (242 aa)
ENSPTRP00000062007SH2B adapter protein 2-like. (570 aa)
PTK6Tyrosine-protein kinase. (451 aa)
INSRTyrosine-protein kinase receptor. (1408 aa)
SHC3SHC3 isoform 2. (598 aa)
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGFR1Fibroblast growth factor receptor. (854 aa)
ENSPTRP00000067174annotation not available (502 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
TEC-2Tec protein tyrosine kinase. (51 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
IGF1Insulin-like growth factor 1 (Somatomedin C). (196 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (585 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (123 aa)
PXNPXN isoform 20. (1078 aa)
INSRRTyrosine-protein kinase receptor. (1297 aa)
TECTyrosine-protein kinase. (631 aa)
PTPN11-2Protein tyrosine phosphatase non-receptor type 11. (579 aa)
ENSPTRP00000073371annotation not available (431 aa)
SH2B2Uncharacterized protein. (677 aa)
P3R3URFPIK3R3 upstream reading frame. (95 aa)
RAPGEF1RAPGEF1 isoform 5. (1065 aa)
ENSPTRP00000074763annotation not available (520 aa)
CK820_G0050194GRAP isoform 1. (153 aa)
SYKTyrosine-protein kinase. (635 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
STAP2Signal transducing adaptor family member 2. (407 aa)
ENSPTRP00000075918annotation not available (365 aa)
GRAPLGRAP isoform 4. (100 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SRCTyrosine-protein kinase. (542 aa)
PIK3R1Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha). (724 aa)
ENSPTRP00000077211annotation not available (269 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FYNTyrosine-protein kinase. (537 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
TXK-2TXK tyrosine kinase. (530 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FRS3-2Fibroblast growth factor receptor substrate 3. (492 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
ENSPTRP00000081537annotation not available (449 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
JAK2Tyrosine-protein kinase. (1143 aa)
SH3KBP1SH3KBP1 isoform 2. (665 aa)
CISHCytokine inducible SH2 containing protein. (275 aa)
CRKV-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
CBLCCbl proto-oncogene C. (474 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSPTRP00000085461annotation not available (478 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. (864 aa)
TXKTyrosine-protein kinase. (527 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
SH3BP2SH3 domain binding protein 2. (618 aa)
ENSPTRP00000088414annotation not available (529 aa)
STAT5BSignal transducer and activator of transcription. (772 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
ENSPTRP00000089450annotation not available (303 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (275 aa)
VAV3VAV3 isoform 2. (927 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
FYB1FYB1 isoform 3. (839 aa)
YES1Tyrosine-protein kinase. (558 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
STAT3Signal transducer and activator of transcription. (790 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ENSPTRP00000092364annotation not available (574 aa)
SOCS7Suppressor of cytokine signaling 7. (580 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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