(26 nodes) Mixed, incl. Signaling by NTRK2 (TRKB), and Helper T cell diapedesis network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHC4	SHC adaptor protein 4. (630 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	GAB1	GRB2-associated-binding protein 1. (724 aa)
	PTK2B	PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	GAB2	GRB2-associated-binding protein 2. (676 aa)
	CRKL	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (303 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	SHC3	SHC3 isoform 2. (598 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	PXN	PXN isoform 20. (1078 aa)
	PTPN11-2	Protein tyrosine phosphatase non-receptor type 11. (579 aa)
	RAPGEF1	RAPGEF1 isoform 5. (1065 aa)
	CK820_G0050194	GRAP isoform 1. (153 aa)
	GRAPL	GRAP isoform 4. (100 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	BCAR1	BCAR1 scaffold protein, Cas family member. (916 aa)
	CRK	V-crk sarcoma virus CT10 oncogene homolog (Avian). (304 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
	ENSPTRP00000089450	annotation not available (303 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (521 aa)
	ENSPTRP00000092364	annotation not available (574 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	CRK	ENSPTRP00000079661	ENSPTRP00000083173	BCAR1 scaffold protein, Cas family member.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.999
BCAR1	CRKL	ENSPTRP00000079661	ENSPTRP00000046677	BCAR1 scaffold protein, Cas family member.	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.	0.987
BCAR1	EGFR	ENSPTRP00000079661	ENSPTRP00000069741	BCAR1 scaffold protein, Cas family member.	Receptor protein-tyrosine kinase.	0.594
BCAR1	ENSPTRP00000089450	ENSPTRP00000079661	ENSPTRP00000089450	BCAR1 scaffold protein, Cas family member.	annotation not available	0.884
BCAR1	ERBB2	ENSPTRP00000079661	ENSPTRP00000069840	BCAR1 scaffold protein, Cas family member.	Receptor protein-tyrosine kinase.	0.616
BCAR1	FYN	ENSPTRP00000079661	ENSPTRP00000077482	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.948
BCAR1	GRB2	ENSPTRP00000079661	ENSPTRP00000016382	BCAR1 scaffold protein, Cas family member.	Growth factor receptor-bound protein 2.	0.869
BCAR1	PTK2	ENSPTRP00000079661	ENSPTRP00000083824	BCAR1 scaffold protein, Cas family member.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.991
BCAR1	PTK2B	ENSPTRP00000079661	ENSPTRP00000034416	BCAR1 scaffold protein, Cas family member.	PTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.994
BCAR1	PXN	ENSPTRP00000079661	ENSPTRP00000071247	BCAR1 scaffold protein, Cas family member.	PXN isoform 20.	0.881
BCAR1	RAPGEF1	ENSPTRP00000079661	ENSPTRP00000074530	BCAR1 scaffold protein, Cas family member.	RAPGEF1 isoform 5.	0.972
BCAR1	SHC1	ENSPTRP00000079661	ENSPTRP00000051735	BCAR1 scaffold protein, Cas family member.	SHC (Src homology 2 domain containing) transforming protein 1.	0.676
BCAR1	SRC	ENSPTRP00000079661	ENSPTRP00000076797	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.998
CK820_G0050194	CRK	ENSPTRP00000074836	ENSPTRP00000083173	GRAP isoform 1.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.501
CK820_G0050194	CRKL	ENSPTRP00000074836	ENSPTRP00000046677	GRAP isoform 1.	V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.	0.513
CK820_G0050194	EGFR	ENSPTRP00000074836	ENSPTRP00000069741	GRAP isoform 1.	Receptor protein-tyrosine kinase.	0.667
CK820_G0050194	ENSPTRP00000089450	ENSPTRP00000074836	ENSPTRP00000089450	GRAP isoform 1.	annotation not available	0.513
CK820_G0050194	ENSPTRP00000092364	ENSPTRP00000074836	ENSPTRP00000092364	GRAP isoform 1.	annotation not available	0.586
CK820_G0050194	ERBB2	ENSPTRP00000074836	ENSPTRP00000069840	GRAP isoform 1.	Receptor protein-tyrosine kinase.	0.667
CK820_G0050194	GAB1	ENSPTRP00000074836	ENSPTRP00000028277	GRAP isoform 1.	GRB2-associated-binding protein 1.	0.777