15 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHC4	SHC adaptor protein 4. (630 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	GAB1	GRB2-associated-binding protein 1. (724 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	GAB2	GRB2-associated-binding protein 2. (676 aa)
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1. (584 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	SHC3	SHC3 isoform 2. (598 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	PTPN11-2	Protein tyrosine phosphatase non-receptor type 11. (579 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSPTRP00000069741	ENSPTRP00000069840	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
EGFR	FYN	ENSPTRP00000069741	ENSPTRP00000077482	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.760
EGFR	GAB1	ENSPTRP00000069741	ENSPTRP00000028277	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 1.	0.997
EGFR	GAB2	ENSPTRP00000069741	ENSPTRP00000045351	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 2.	0.957
EGFR	GRB2	ENSPTRP00000069741	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.999
EGFR	PTK2	ENSPTRP00000069741	ENSPTRP00000083824	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.995
EGFR	PTPN11	ENSPTRP00000069741	ENSPTRP00000061336	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.994
EGFR	PTPN11-2	ENSPTRP00000069741	ENSPTRP00000073224	Receptor protein-tyrosine kinase.	Protein tyrosine phosphatase non-receptor type 11.	0.948
EGFR	SHC1	ENSPTRP00000069741	ENSPTRP00000051735	Receptor protein-tyrosine kinase.	SHC (Src homology 2 domain containing) transforming protein 1.	0.999
EGFR	SHC3	ENSPTRP00000069741	ENSPTRP00000063600	Receptor protein-tyrosine kinase.	SHC3 isoform 2.	0.987
EGFR	SHC4	ENSPTRP00000069741	ENSPTRP00000012048	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.986
EGFR	SOS1	ENSPTRP00000069741	ENSPTRP00000052023	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
EGFR	SOS2	ENSPTRP00000069741	ENSPTRP00000043790	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.995
EGFR	SRC	ENSPTRP00000069741	ENSPTRP00000076797	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.998
ERBB2	EGFR	ENSPTRP00000069840	ENSPTRP00000069741	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
ERBB2	FYN	ENSPTRP00000069840	ENSPTRP00000077482	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.608
ERBB2	GAB1	ENSPTRP00000069840	ENSPTRP00000028277	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 1.	0.962
ERBB2	GAB2	ENSPTRP00000069840	ENSPTRP00000045351	Receptor protein-tyrosine kinase.	GRB2-associated-binding protein 2.	0.596
ERBB2	GRB2	ENSPTRP00000069840	ENSPTRP00000016382	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2.	0.998
ERBB2	PTK2	ENSPTRP00000069840	ENSPTRP00000083824	Receptor protein-tyrosine kinase.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.861