(43 nodes) Mixed, incl. RHOU GTPase cycle, and FCH domain network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARHGAP1	Rho GTPase activating protein 1. (439 aa)
	PAK1	Non-specific serine/threonine protein kinase. (553 aa)
	PAK6	Non-specific serine/threonine protein kinase. (681 aa)
	BNIP2	BNIP2 isoform 1. (427 aa)
	MYO9A	MYO9A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2547 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1657 aa)
	GAS7	Growth arrest-specific 7. (476 aa)
	ARHGAP30	ARHGAP30 isoform 3. (1101 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	PAK5	Non-specific serine/threonine protein kinase. (719 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	PAK2	Non-specific serine/threonine protein kinase. (476 aa)
	WIPF3	WAS/WASL interacting protein family member 3. (483 aa)
	WASL	WASP like actin nucleation promoting factor. (505 aa)
	FNBP1	Formin binding protein 1. (620 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (783 aa)
	FCHSD1	FCH and double SH3 domains 1. (690 aa)
	RHOV	Ras homolog family member V. (236 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1589 aa)
	GIT1	G protein-coupled receptor kinase interacting ArfGAP 1. (770 aa)
	ENSPTRP00000060141	annotation not available (172 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	PAK3	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] (580 aa)
	WIPF2	WAS/WASL interacting protein family, member 2. (440 aa)
	ENSPTRP00000066583	annotation not available (181 aa)
	FNBP1L	Formin binding protein 1 like. (611 aa)
	RND2	Rho family GTPase 2. (227 aa)
	ARHGAP8	PRR5-ARHGAP8 isoform 3. (464 aa)
	ENSPTRP00000074085	annotation not available (188 aa)
	WIPF1	WAS/WASL interacting protein family, member 1. (554 aa)
	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2. (760 aa)
	CLIP1	CAP-Gly domain containing linker protein 1. (1433 aa)
	TRIP10	Thyroid hormone receptor interactor 10. (601 aa)
	ENSPTRP00000081694	annotation not available (182 aa)
	ITSN1	ITSN1 isoform 4. (1721 aa)
	KALRN	Kalirin RhoGEF kinase. (2986 aa)
	IQGAP2	IQ motif containing GTPase activating protein 2. (1600 aa)
	RHOU	Ras homolog family member U. (258 aa)
	ARHGAP4	Rho GTPase activating protein 4. (986 aa)
	PAK4	Non-specific serine/threonine protein kinase. (593 aa)
	WAS-2	WASP actin nucleation promoting factor. (502 aa)
	ITSN1-2	ITSN1 isoform 7. (1716 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP1	ARHGEF6	ENSPTRP00000006166	ENSPTRP00000043151	Rho GTPase activating protein 1.	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.421
ARHGAP1	ARHGEF7	ENSPTRP00000006166	ENSPTRP00000062187	Rho GTPase activating protein 1.	Rho guanine nucleotide exchange factor 7.	0.445
ARHGAP1	BNIP2	ENSPTRP00000006166	ENSPTRP00000012187	Rho GTPase activating protein 1.	BNIP2 isoform 1.	0.908
ARHGAP1	ENSPTRP00000060141	ENSPTRP00000006166	ENSPTRP00000060141	Rho GTPase activating protein 1.	annotation not available	0.520
ARHGAP1	ENSPTRP00000066583	ENSPTRP00000006166	ENSPTRP00000066583	Rho GTPase activating protein 1.	annotation not available	0.844
ARHGAP1	ENSPTRP00000074085	ENSPTRP00000006166	ENSPTRP00000074085	Rho GTPase activating protein 1.	annotation not available	0.514
ARHGAP1	ENSPTRP00000081694	ENSPTRP00000006166	ENSPTRP00000081694	Rho GTPase activating protein 1.	annotation not available	0.844
ARHGAP1	FNBP1	ENSPTRP00000006166	ENSPTRP00000036723	Rho GTPase activating protein 1.	Formin binding protein 1.	0.413
ARHGAP1	FNBP1L	ENSPTRP00000006166	ENSPTRP00000066861	Rho GTPase activating protein 1.	Formin binding protein 1 like.	0.451
ARHGAP1	GIT1	ENSPTRP00000006166	ENSPTRP00000059492	Rho GTPase activating protein 1.	G protein-coupled receptor kinase interacting ArfGAP 1.	0.427
ARHGAP1	GIT2	ENSPTRP00000006166	ENSPTRP00000075299	Rho GTPase activating protein 1.	G protein-coupled receptor kinase interacting ArfGAP 2.	0.405
ARHGAP1	IQGAP1	ENSPTRP00000006166	ENSPTRP00000012743	Rho GTPase activating protein 1.	IQ motif containing GTPase activating protein 1.	0.602
ARHGAP1	IQGAP2	ENSPTRP00000006166	ENSPTRP00000087767	Rho GTPase activating protein 1.	IQ motif containing GTPase activating protein 2.	0.430
ARHGAP1	IQGAP3	ENSPTRP00000006166	ENSPTRP00000051711	Rho GTPase activating protein 1.	IQ motif containing GTPase activating protein 3.	0.525
ARHGAP1	MYO9A	ENSPTRP00000006166	ENSPTRP00000012382	Rho GTPase activating protein 1.	MYO9A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.660
ARHGAP1	PAK1	ENSPTRP00000006166	ENSPTRP00000007058	Rho GTPase activating protein 1.	Non-specific serine/threonine protein kinase.	0.435
ARHGAP1	PAK2	ENSPTRP00000006166	ENSPTRP00000027164	Rho GTPase activating protein 1.	Non-specific serine/threonine protein kinase.	0.551
ARHGAP1	PAK3	ENSPTRP00000006166	ENSPTRP00000062580	Rho GTPase activating protein 1.	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]	0.421
ARHGAP1	RHOU	ENSPTRP00000006166	ENSPTRP00000087997	Rho GTPase activating protein 1.	Ras homolog family member U.	0.541
ARHGAP1	RHOV	ENSPTRP00000006166	ENSPTRP00000051609	Rho GTPase activating protein 1.	Ras homolog family member V.	0.520