(6 nodes) Mixed, incl. Cytotoxic T-lymphocyte protein 4/CD28, and Immunoglobulin domain network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD28	CD28 isoform 3. (220 aa)
	CD80	CD80 isoform 1. (288 aa)
	CD86	CD86 isoform 3. (329 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	PDCD1	Programmed cell death 1. (288 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (288 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	CD80	ENSPTRP00000021943	ENSPTRP00000026304	CD28 isoform 3.	CD80 isoform 1.	0.999
CD28	CD86	ENSPTRP00000021943	ENSPTRP00000026356	CD28 isoform 3.	CD86 isoform 3.	0.999
CD28	CTLA4	ENSPTRP00000021943	ENSPTRP00000080210	CD28 isoform 3.	Cytotoxic T-lymphocyte associated protein 4.	0.860
CD28	PDCD1	ENSPTRP00000021943	ENSPTRP00000080804	CD28 isoform 3.	Programmed cell death 1.	0.705
CD28	PDCD1LG2	ENSPTRP00000021943	ENSPTRP00000092173	CD28 isoform 3.	Programmed cell death 1 ligand 2.	0.794
CD80	CD28	ENSPTRP00000026304	ENSPTRP00000021943	CD80 isoform 1.	CD28 isoform 3.	0.999
CD80	CD86	ENSPTRP00000026304	ENSPTRP00000026356	CD80 isoform 1.	CD86 isoform 3.	0.998
CD80	CTLA4	ENSPTRP00000026304	ENSPTRP00000080210	CD80 isoform 1.	Cytotoxic T-lymphocyte associated protein 4.	0.999
CD80	PDCD1	ENSPTRP00000026304	ENSPTRP00000080804	CD80 isoform 1.	Programmed cell death 1.	0.923
CD80	PDCD1LG2	ENSPTRP00000026304	ENSPTRP00000092173	CD80 isoform 1.	Programmed cell death 1 ligand 2.	0.862
CD86	CD28	ENSPTRP00000026356	ENSPTRP00000021943	CD86 isoform 3.	CD28 isoform 3.	0.999
CD86	CD80	ENSPTRP00000026356	ENSPTRP00000026304	CD86 isoform 3.	CD80 isoform 1.	0.998
CD86	CTLA4	ENSPTRP00000026356	ENSPTRP00000080210	CD86 isoform 3.	Cytotoxic T-lymphocyte associated protein 4.	0.999
CD86	PDCD1	ENSPTRP00000026356	ENSPTRP00000080804	CD86 isoform 3.	Programmed cell death 1.	0.898
CD86	PDCD1LG2	ENSPTRP00000026356	ENSPTRP00000092173	CD86 isoform 3.	Programmed cell death 1 ligand 2.	0.806
CTLA4	CD28	ENSPTRP00000080210	ENSPTRP00000021943	Cytotoxic T-lymphocyte associated protein 4.	CD28 isoform 3.	0.860
CTLA4	CD80	ENSPTRP00000080210	ENSPTRP00000026304	Cytotoxic T-lymphocyte associated protein 4.	CD80 isoform 1.	0.999
CTLA4	CD86	ENSPTRP00000080210	ENSPTRP00000026356	Cytotoxic T-lymphocyte associated protein 4.	CD86 isoform 3.	0.999
CTLA4	PDCD1	ENSPTRP00000080210	ENSPTRP00000080804	Cytotoxic T-lymphocyte associated protein 4.	Programmed cell death 1.	0.918
CTLA4	PDCD1LG2	ENSPTRP00000080210	ENSPTRP00000092173	Cytotoxic T-lymphocyte associated protein 4.	Programmed cell death 1 ligand 2.	0.924