STRINGSTRING
POU4F1 POU4F1 NES NES LEFTY2 LEFTY2 ATOH7 ATOH7 NODAL NODAL EMX2 EMX2 NKX6-2 NKX6-2 DRAP1 DRAP1 GDF3 GDF3 DPPA3 DPPA3 NANOG NANOG DBX2 DBX2 FOXN4 FOXN4 PDX1 PDX1 SALL2 SALL2 INSM2 INSM2 OTX2 OTX2 VSX2 VSX2 ZSCAN10 ZSCAN10 IRX6 IRX6 FOXF1 FOXF1 MYOCD MYOCD TBX2 TBX2 TBX4 TBX4 SOX9 SOX9 GATA6 GATA6 DAND5 DAND5 FOXA3 FOXA3 VAX2 VAX2 GBX2 GBX2 NKX2-2 NKX2-2 LMCD1 LMCD1 EOMES EOMES TDGF1 TDGF1 PROM1 PROM1 GSX2 GSX2 NKX6-1 NKX6-1 POU4F2 POU4F2 PITX1 PITX1 NEUROG1 NEUROG1 NKX2-5 NKX2-5 POU5F1 POU5F1 TBXT TBXT NEUROD6 NEUROD6 PAX4 PAX4 SOX17 SOX17 FOXH1 FOXH1 DMRT1 DMRT1 KLF4 KLF4 NR5A1 NR5A1 MAP2 MAP2 CLEC4C CLEC4C TBR1 TBR1 SOX2 SOX2 BARX1 BARX1 NR0B1 NR0B1 FOXF2 FOXF2 HAND2 HAND2 BCL11B BCL11B FOXH1-2 FOXH1-2 RIPPLY3 RIPPLY3 SP8 SP8 EMX1 EMX1 NEUROG3 NEUROG3 SOX1 SOX1 ANHX ANHX NEUROD4 NEUROD4 HES1 HES1 ESRRB ESRRB ENSPTRP00000064903 ENSPTRP00000064903 ENSPTRP00000065099 ENSPTRP00000065099 PAX6 PAX6 ZIC3 ZIC3 GDF1 GDF1 DBX1 DBX1 NKX3-2 NKX3-2 ENSPTRP00000068971 ENSPTRP00000068971 TBX5 TBX5 VRTN VRTN ENSPTRP00000069764 ENSPTRP00000069764 MIXL1 MIXL1 ENSPTRP00000071338 ENSPTRP00000071338 ENSPTRP00000071463 ENSPTRP00000071463 FOXD2 FOXD2 ENSPTRP00000073411 ENSPTRP00000073411 ONECUT1 ONECUT1 ENSPTRP00000074225 ENSPTRP00000074225 GATA5 GATA5 FOXP1 FOXP1 ZFPM2 ZFPM2 GATA4 GATA4 SALL4 SALL4 ENSPTRP00000076822 ENSPTRP00000076822 NR2F2 NR2F2 ENSPTRP00000079007 ENSPTRP00000079007 LEFTY1 LEFTY1 FEZF2 FEZF2 OLIG1-2 OLIG1-2 SATB2 SATB2 HNF1B HNF1B ENSPTRP00000082402 ENSPTRP00000082402 PTF1A PTF1A ENSPTRP00000083127 ENSPTRP00000083127 FGF10 FGF10 NEUROG2 NEUROG2 HNF1A HNF1A TBX3 TBX3 ENSPTRP00000085820 ENSPTRP00000085820 PRDM14 PRDM14 ENSPTRP00000086503 ENSPTRP00000086503 HNF4A HNF4A WT1 WT1 NR2F1 NR2F1 ENSPTRP00000088702 ENSPTRP00000088702 CUX2 CUX2 FOXA2 FOXA2 POU5F1B POU5F1B ENSPTRP00000090372 ENSPTRP00000090372 SOX3 SOX3 LOC459608 LOC459608 RBFOX3 RBFOX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POU4F1POU domain protein. (350 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1620 aa)
LEFTY2Left-right determination factor. (366 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
NODALNODAL isoform 2. (347 aa)
EMX2Empty spiracles homeobox 2. (252 aa)
NKX6-2NKX6-2 isoform 1. (276 aa)
DRAP1DR1-associated protein 1 (Negative cofactor 2 alpha). (205 aa)
GDF3Growth differentiation factor 3. (364 aa)
DPPA3Developmental pluripotency associated 3. (159 aa)
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)
DBX2Developing brain homeobox 2. (339 aa)
FOXN4FOXN4 isoform 2. (517 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
SALL2Spalt like transcription factor 2. (1007 aa)
INSM2INSM transcriptional repressor 2. (568 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
VSX2VSX2 isoform 1. (380 aa)
ZSCAN10ZSCAN10 isoform 1. (780 aa)
IRX6Iroquois homeobox 6. (445 aa)
FOXF1FOXF1 isoform 1. (433 aa)
MYOCDMYOCD isoform 2. (986 aa)
TBX2T-box transcription factor 2. (712 aa)
TBX4TBX4 isoform 1. (545 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
GATA6GATA binding protein 6. (594 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
FOXA3FOXA3 isoform 2. (350 aa)
VAX2Ventral anterior homeobox 2. (290 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
LMCD1LIM and cysteine-rich domains 1. (365 aa)
EOMESEOMES isoform 2. (704 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
PROM1PROM1 isoform 12. (865 aa)
GSX2GSX2 isoform 2. (304 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
POU4F2POU domain protein. (406 aa)
PITX1Homeobox protein. (314 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
NKX2-5NKX2-5 isoform 1. (325 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). (360 aa)
TBXTT-box transcription factor T. (435 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
PAX4PAX4 isoform 1. (351 aa)
SOX17SOX17 isoform 1. (416 aa)
FOXH1FOXH1 isoform 1. (365 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (371 aa)
KLF4Kruppel-like factor 4 (Gut). (479 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
MAP2Microtubule-associated protein. (1827 aa)
CLEC4CC-type lectin domain family 4 member C. (213 aa)
TBR1T-box brain transcription factor 1. (682 aa)
SOX2SRY-box transcription factor 2. (319 aa)
BARX1BARX homeobox 1. (254 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (470 aa)
FOXF2FOXF2 isoform 1. (444 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (894 aa)
FOXH1-2Forkhead box H1. (365 aa)
RIPPLY3RIPPLY3 isoform 3. (189 aa)
SP8Sp8 transcription factor. (507 aa)
EMX1Empty spiracles homeobox 1. (290 aa)
NEUROG3NEUROG3 isoform 1. (214 aa)
SOX1SOX1 isoform 1. (391 aa)
ANHXAnomalous homeobox. (379 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ESRRBEstrogen related receptor beta. (508 aa)
ENSPTRP00000064903annotation not available (150 aa)
ENSPTRP00000065099annotation not available (337 aa)
PAX6PAX6 isoform 13. (436 aa)
ZIC3Zic family member 3. (466 aa)
GDF1CERS1 isoform 2. (372 aa)
DBX1Developing brain homeobox 1. (345 aa)
NKX3-2NKX3-2 isoform 1. (333 aa)
ENSPTRP00000068971annotation not available (348 aa)
TBX5T-box transcription factor 5. (518 aa)
VRTNVertebrae development associated. (702 aa)
ENSPTRP00000069764annotation not available (1213 aa)
MIXL1Mix paired-like homeobox. (232 aa)
ENSPTRP00000071338annotation not available (290 aa)
ENSPTRP00000071463LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 4. (205 aa)
FOXD2FOXD2 isoform 1. (493 aa)
ENSPTRP00000073411annotation not available (299 aa)
ONECUT1One cut domain family member. (465 aa)
ENSPTRP00000074225annotation not available (780 aa)
GATA5GATA binding protein 5. (397 aa)
FOXP1FOXP1 isoform 2. (693 aa)
ZFPM2ZFPM2 isoform 3. (1151 aa)
GATA4GATA binding protein 4. (443 aa)
SALL4SALL4 isoform 1. (1053 aa)
ENSPTRP00000076822annotation not available (142 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
ENSPTRP00000079007annotation not available (323 aa)
LEFTY1Left-right determination factor. (366 aa)
FEZF2FEZ family zinc finger 2. (463 aa)
OLIG1-2OLIG1 isoform 1. (272 aa)
SATB2DNA-binding protein SATB. (733 aa)
HNF1BHNF1 homeobox B. (557 aa)
ENSPTRP00000082402annotation not available (277 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
ENSPTRP00000083127annotation not available (244 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NEUROG2NEUROG2 isoform 1. (272 aa)
HNF1AHNF1 homeobox A. (662 aa)
TBX3T-box transcription factor 3. (743 aa)
ENSPTRP00000085820annotation not available (199 aa)
PRDM14PR/SET domain 14. (571 aa)
ENSPTRP00000086503annotation not available (166 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
WT1WT1 transcription factor. (514 aa)
NR2F1Nuclear receptor subfamily 2 group F member 1. (423 aa)
ENSPTRP00000088702annotation not available (170 aa)
CUX2Homeobox protein cut-like. (1489 aa)
FOXA2FOXA2 isoform 1. (464 aa)
POU5F1BPOU domain protein. (359 aa)
ENSPTRP00000090372annotation not available (274 aa)
SOX3SRY-box transcription factor 3. (446 aa)
LOC459608CFC1B isoform 2. (223 aa)
RBFOX3RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (373 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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