17 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX6-2	NKX6-2 isoform 1. (276 aa)
	PDX1	Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
	INSM2	INSM transcriptional repressor 2. (568 aa)
	FOXA3	FOXA3 isoform 2. (350 aa)
	NKX2-2	NKX2-2 isoform 1. (273 aa)
	NKX6-1	NKX6-1 isoform 2. (367 aa)
	PAX4	PAX4 isoform 1. (351 aa)
	RIPPLY3	RIPPLY3 isoform 3. (189 aa)
	NEUROG3	NEUROG3 isoform 1. (214 aa)
	HES1	Hes family bHLH transcription factor 1. (280 aa)
	ONECUT1	One cut domain family member. (465 aa)
	HNF1B	HNF1 homeobox B. (557 aa)
	PTF1A	Pancreas associated transcription factor 1a. (328 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	FOXA2	FOXA2 isoform 1. (464 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF10	PDX1	ENSPTRP00000083399	ENSPTRP00000009769	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...]	0.769
FGF10	PTF1A	ENSPTRP00000083399	ENSPTRP00000083121	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Pancreas associated transcription factor 1a.	0.689
FOXA2	HNF1A	ENSPTRP00000090114	ENSPTRP00000084678	FOXA2 isoform 1.	HNF1 homeobox A.	0.711
FOXA2	HNF4A	ENSPTRP00000090114	ENSPTRP00000087554	FOXA2 isoform 1.	Hepatocyte nuclear factor 4 alpha.	0.694
FOXA2	NEUROG3	ENSPTRP00000090114	ENSPTRP00000060199	FOXA2 isoform 1.	NEUROG3 isoform 1.	0.592
FOXA2	NKX2-2	ENSPTRP00000090114	ENSPTRP00000022825	FOXA2 isoform 1.	NKX2-2 isoform 1.	0.693
FOXA2	NKX6-1	ENSPTRP00000090114	ENSPTRP00000027895	FOXA2 isoform 1.	NKX6-1 isoform 2.	0.658
FOXA2	NKX6-2	ENSPTRP00000090114	ENSPTRP00000005418	FOXA2 isoform 1.	NKX6-2 isoform 1.	0.673
FOXA2	ONECUT1	ENSPTRP00000090114	ENSPTRP00000073859	FOXA2 isoform 1.	One cut domain family member.	0.730
FOXA2	PAX4	ENSPTRP00000090114	ENSPTRP00000033650	FOXA2 isoform 1.	PAX4 isoform 1.	0.469
FOXA2	PDX1	ENSPTRP00000090114	ENSPTRP00000009769	FOXA2 isoform 1.	Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...]	0.877
FOXA2	PTF1A	ENSPTRP00000090114	ENSPTRP00000083121	FOXA2 isoform 1.	Pancreas associated transcription factor 1a.	0.463
FOXA3	HNF1A	ENSPTRP00000019177	ENSPTRP00000084678	FOXA3 isoform 2.	HNF1 homeobox A.	0.838
FOXA3	HNF1B	ENSPTRP00000019177	ENSPTRP00000082398	FOXA3 isoform 2.	HNF1 homeobox B.	0.500
FOXA3	HNF4A	ENSPTRP00000019177	ENSPTRP00000087554	FOXA3 isoform 2.	Hepatocyte nuclear factor 4 alpha.	0.536
FOXA3	NKX2-2	ENSPTRP00000019177	ENSPTRP00000022825	FOXA3 isoform 2.	NKX2-2 isoform 1.	0.403
FOXA3	ONECUT1	ENSPTRP00000019177	ENSPTRP00000073859	FOXA3 isoform 2.	One cut domain family member.	0.479
FOXA3	PDX1	ENSPTRP00000019177	ENSPTRP00000009769	FOXA3 isoform 2.	Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...]	0.505
HES1	NEUROG3	ENSPTRP00000064171	ENSPTRP00000060199	Hes family bHLH transcription factor 1.	NEUROG3 isoform 1.	0.981
HES1	PTF1A	ENSPTRP00000064171	ENSPTRP00000083121	Hes family bHLH transcription factor 1.	Pancreas associated transcription factor 1a.	0.592