STRINGSTRING
SKI SKI PAX7 PAX7 ENSPTRP00000000998 ENSPTRP00000000998 ZFYVE9 ZFYVE9 ALX3 ALX3 BGLAP BGLAP PRRX1 PRRX1 TGFB2 TGFB2 MKX MKX BMPR1A BMPR1A LTBP3 LTBP3 ACVRL1 ACVRL1 ACVR1B ACVR1B GDF11 GDF11 INHBC INHBC INHBE INHBE MYF6 MYF6 MYF5 MYF5 LRRIQ1 LRRIQ1 ALX1 ALX1 DACH1 DACH1 BMP4 BMP4 TGFB3 TGFB3 RNF111 RNF111 SMAD6 SMAD6 CLEC3A CLEC3A MEOX1 MEOX1 NOG NOG SMAD7 SMAD7 SMAD4 SMAD4 FSTL3 FSTL3 AMH AMH LTBP4 LTBP4 TGFB1 TGFB1 GDF7 GDF7 SIX2 SIX2 ACVR2A ACVR2A ACVR1C ACVR1C MSTN MSTN INHA INHA BMP2 BMP2 GDF5 GDF5 BMP7 BMP7 BMPR1B BMPR1B SMAD1 SMAD1 FSTL5 FSTL5 FST FST ZFYVE16 ZFYVE16 MSX2 MSX2 BMP6 BMP6 SMIM29 SMIM29 BMP5 BMP5 TCF21 TCF21 MEOX2 MEOX2 BMPER BMPER DLX5 DLX5 SNAI2 SNAI2 EYA1 EYA1 ENG ENG SLC26A3 SLC26A3 SOX10 SOX10 SIX4 SIX4 TNMD TNMD SMURF1 SMURF1 TWIST1 TWIST1 BMPR2 BMPR2 FOXD3 FOXD3 MSX1 MSX1 SMAD9 SMAD9 DLX6 DLX6 TMEFF1 TMEFF1 SMAD2 SMAD2 ENSPTRP00000064416 ENSPTRP00000064416 TBX15 TBX15 RUNX2 RUNX2 SNAI1 SNAI1 TGFBR3 TGFBR3 LRRC32 LRRC32 GDF2 GDF2 NBL1 NBL1 CHRDL2 CHRDL2 SIX1 SIX1 SKIL SKIL TLX1 TLX1 LOC748658 LOC748658 TGFBR1 TGFBR1 SCX SCX TGFBR2 TGFBR2 ACVR1 ACVR1 GDF6 GDF6 ACVR2B ACVR2B BMP10 BMP10 SP7 SP7 SMAD5 SMAD5 BMP4-2 BMP4-2 CHRDL1 CHRDL1 WFIKKN2 WFIKKN2 HJV HJV CHRD CHRD SMURF2 SMURF2 SMAD3 SMAD3 PAX3 PAX3 GREM2 GREM2 INHBB INHBB PAX2 PAX2 EYA2 EYA2 EYA4 EYA4 INHBA INHBA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKIV-ski sarcoma viral oncogene homolog (Avian). (736 aa)
PAX7PAX7 isoform 2. (505 aa)
ENSPTRP00000000998annotation not available (224 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
ALX3ALX homeobox 3. (343 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
PRRX1Paired related homeobox 1. (245 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MKXMohawk homeobox. (352 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
GDF11GDF11 isoform 1. (407 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (350 aa)
MYF6Myogenic factor 6. (242 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
LRRIQ1LRRIQ1 isoform 3. (1722 aa)
ALX1ALX homeobox 1. (326 aa)
DACH1DACH1 isoform 4. (761 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RNF111RNF111 isoform 5. (1003 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
CLEC3AC-type lectin domain family 3 member A. (206 aa)
MEOX1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independen [...] (254 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD7Mothers against decapentaplegic homolog. (491 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FSTL3Follistatin-like 3 (Secreted glycoprotein). (263 aa)
AMHAnti-Mullerian hormone. (560 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GDF7Growth differentiation factor 7. (447 aa)
SIX2SIX homeobox 2. (291 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (376 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
GDF5GDF5 isoform 1. (501 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
FSTL5FSTL5 isoform 1. (847 aa)
FSTFST isoform 1. (344 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1539 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity); Belongs to the Msh homeobox family. (267 aa)
BMP6Bone morphogenetic protein 6. (512 aa)
SMIM29Small integral membrane protein 29. (102 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TCF21Transcription factor 21. (179 aa)
MEOX2Mesenchyme homeobox 2. (302 aa)
BMPERBMP binding endothelial regulator. (685 aa)
DLX5Distal-less homeobox 5. (289 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
ENGENG isoform 1. (658 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (762 aa)
SOX10SRY-box transcription factor 10. (466 aa)
SIX4SIX homeobox 4. (781 aa)
TNMDTNMD isoform 1. (317 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
TWIST1TWIST1 isoform 2. (163 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
FOXD3FOXD3 isoform 1. (478 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
DLX6DLX6 isoform 1. (295 aa)
TMEFF1Transmembrane protein with EGF like and two follistatin like domains 1. (454 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSPTRP00000064416annotation not available (502 aa)
TBX15T-box transcription factor 15. (602 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
GDF2GDF2 isoform 1. (429 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (216 aa)
CHRDL2CHRDL2 isoform 2. (452 aa)
SIX1SIX homeobox 1. (284 aa)
SKILSKI like proto-oncogene. (684 aa)
TLX1T cell leukemia homeobox 1. (330 aa)
LOC748658LOW QUALITY PROTEIN: homeobox protein MSX-2-like. (312 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GDF6Growth differentiation factor 6. (455 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SP7Sp7 transcription factor. (431 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
CHRDL1CHRDL1 isoform 3. (458 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
HJVHFE2 isoform 1. (426 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (955 aa)
SMURF2E3 ubiquitin-protein ligase. (744 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
PAX3PAX3 isoform 4. (505 aa)
GREM2Gremlin. (168 aa)
INHBBInhibin subunit beta B. (407 aa)
PAX2PAX2 isoform 1. (417 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
INHBAInhibin subunit beta A. (426 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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