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| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (308 aa) |
| | RSPO1 | RSPO1 isoform 3. (263 aa) |
| | LRP8 | LDL receptor related protein 8. (960 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa) |
| | VANGL1 | Vang-like protein. (524 aa) |
| | RNF115 | Ring finger protein 115. (304 aa) |
| | VANGL2 | Vang-like protein. (521 aa) |
| | LGR6 | LGR6 isoform 2. (967 aa) |
| | DISP1 | Dispatched RND transporter family member 1. (1525 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | PTCHD3 | Patched domain containing 3. (769 aa) |
| | BAMBI | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa) |
| | DKK1 | Dickkopf-like protein 1. (289 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (233 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | SYT9 | Synaptotagmin IX. (491 aa) |
| | LDLRAD3 | Low density lipoprotein receptor class A domain containing 3. (345 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | FZD4 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | WIF1 | WNT inhibitory factor 1. (379 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | ZIC2 | ZIC2 isoform 1. (533 aa) |
| | GSKIP | Chromosome 14 open reading frame 129. (139 aa) |
| | KREMEN2 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | SOST | SOST isoform 1. (213 aa) |
| | FZD2 | FZD2 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | SPOP | Speckle type BTB/POZ protein. (374 aa) |
| | AXIN2 | AXIN2 isoform 1. (843 aa) |
| | GPR142 | G protein-coupled receptor 142; Belongs to the G-protein coupled receptor 1 family. (462 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha. (483 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | LRP2 | LRP2 isoform 1. (4655 aa) |
| | FRZB | Frizzled-related protein. (325 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | STK36 | Serine/threonine kinase 36. (1315 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) |
| | RSPO4 | RSPO4 isoform 1. (234 aa) |
| | LRP5L | LDL receptor related protein 5 like. (252 aa) |
| | ZNRF3 | ZNRF3 isoform 1. (920 aa) |
| | LRTM1 | LRTM1 isoform 2. (345 aa) |
| | RYK | Receptor like tyrosine kinase. (610 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (716 aa) |
| | LRPAP1 | Low density lipoprotein receptor-related protein associated protein 1. (357 aa) |
| | EVC2 | EvC ciliary complex subunit 2. (1308 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | HHIP | Hedgehog interacting protein. (700 aa) |
| | SFRP2 | Secreted frizzled-related protein 2. (295 aa) |
| | HPGD | 15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa) |
| | APC | Adenomatous polyposis coli protein isoform X10. (2844 aa) |
| | OGFRL1 | Opioid growth factor receptor-like 1. (452 aa) |
| | RSPO3 | RSPO3 isoform 1. (292 aa) |
| | SFRP4 | SFRP4 isoform 1. (368 aa) |
| | GLI3 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | TSPAN12 | Tetraspanin. (305 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | SMO | SMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa) |
| | MFHAS1 | Malignant fibrous histiocytoma amplified sequence 1. (1052 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (224 aa) |
| | LRP12 | Low density lipoprotein receptor-related protein 12. (859 aa) |
| | GLIS3 | GLIS family zinc finger 3. (930 aa) |
| | CER1 | CER1 isoform 1. (267 aa) |
| | ROR2 | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa) |
| | NDP | Norrin cystine knot growth factor NDP. (133 aa) |
| | CK820_G0018745 | FZD8 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (628 aa) |
| | GLI2 | GLI family zinc finger 2. (1587 aa) |
| | AXIN1 | AXIN1 isoform 2. (859 aa) |
| | SLC17A3 | Solute carrier family 17 member 3. (498 aa) |
| | FZD6 | Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | CTNNB1 | Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa) |
| | PRICKLE4 | PRICKLE4 isoform 4. (383 aa) |
| | AMER1 | APC membrane recruitment protein 1. (805 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | VLDLR | Very low density lipoprotein receptor. (874 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa) |
| | HECTD4 | HECT domain E3 ubiquitin protein ligase 4. (4416 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | EFCAB7 | EF-hand calcium binding domain 7. (629 aa) |
| | DAB1 | DAB adaptor protein 1. (588 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (496 aa) |
| | FAM83H | Family with sequence similarity 83 member H. (1179 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (314 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (470 aa) |
| | EVC | EVC isoform 1. (991 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa) |
| | RNF43 | Ring finger protein 43. (783 aa) |
| | RELN | RELN isoform 3. (3460 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | CSNK1A1L | Casein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa) |
| | PORCN | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | RSPO2 | R-spondin 2 homolog. (243 aa) |
| | WNT7A | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa) |
| | PRICKLE2 | Prickle planar cell polarity protein 2. (900 aa) |
| | ENSPTRP00000065085 | annotation not available (133 aa) |
| | CSNK1A1 | Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa) |
| | ENSPTRP00000066776 | annotation not available (570 aa) |
| | ENSPTRP00000066927 | annotation not available (133 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (317 aa) |
| | SMO-2 | Smoothened, frizzled class receptor. (786 aa) |
| | ENSPTRP00000067619 | annotation not available (224 aa) |
| | GPC3 | Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled recept [...] (563 aa) |
| | CDON | Cell adhesion associated, oncogene regulated. (1286 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (464 aa) |
| | PTCH2 | PTCH2 isoform 3. (1203 aa) |
| | PJA2 | Praja ring finger ubiquitin ligase 2. (708 aa) |
| | LRP1 | LDL receptor related protein 1. (4544 aa) |
| | PTPRU | Protein tyrosine phosphatase receptor type U. (1454 aa) |
| | DAB2 | Disabled homolog 2, mitogen-responsive phosphoprotein. (770 aa) |
| | WLS | Wnt ligand secretion mediator. (543 aa) |
| | MATN2 | MATN2 isoform 2. (956 aa) |
| | PRICKLE3 | Prickle planar cell polarity protein 3. (614 aa) |
| | DVL1 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa) |
| | SUFU | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa) |
| | DAAM2 | Dishevelled associated activator of morphogenesis 2. (1077 aa) |
| | NMRK1 | NMRK1 isoform 1. (219 aa) |
| | DHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa) |
| | LDLR | LDLR isoform 7. (917 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa) |
| | WNT9B-2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | DAAM1 | Dishevelled associated activator of morphogenesis 1. (1078 aa) |
| | GAS1 | Growth arrest-specific 1. (370 aa) |
| | WNT3-2 | Wnt family member 3. (290 aa) |
| | GLI1 | GLI family zinc finger 1. (1106 aa) |
| | ANKRD6 | Ankyrin repeat domain 6. (727 aa) |
| | CTNNBIP1 | Catenin, beta interacting protein 1. (81 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | LGR5 | Leucine rich repeat containing G protein-coupled receptor 5. (907 aa) |
| | FRAT1 | FRAT regulator of WNT signaling pathway 1. (279 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (481 aa) |
| | KIF7 | Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1281 aa) |
| | ENSPTRP00000083999 | annotation not available (92 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | ROR1 | Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (945 aa) |
| | PTCH1 | PTCH1 isoform 8. (1428 aa) |
| | FZD1 | FZD1 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) |
| | PRICKLE1 | PRICKLE1 isoform 11. (831 aa) |
| | APC2 | APC2 isoform 1. (2301 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa) |
| | CK820_G0007203 | PRICKLE4 isoform 1. (385 aa) |
| | MXRA8 | Matrix remodeling associated 8. (446 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (413 aa) |
| | ACAD10 | Acyl-CoA dehydrogenase family member 10 isoform X1. (1091 aa) |
| | HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1608 aa) |
| | BOC | BOC cell adhesion associated, oncogene regulated. (1115 aa) |
| | FZD1-2 | Frizzled class receptor 1. (580 aa) |
| | LGR4 | LGR4 isoform 2. (951 aa) |
