30 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPEN	Spen family transcriptional repressor. (3662 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1150 aa)
	DTX1	Deltex E3 ubiquitin ligase 1. (620 aa)
	LFNG-2	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (242 aa)
	NOTCH3	NOTCH3 isoform 1. (2321 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	NOTCH1	NOTCH1 isoform 1. (2555 aa)
	HES5	Hes family bHLH transcription factor 5. (165 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	HES4	Hes family bHLH transcription factor 4. (221 aa)
	DNER	Delta/notch-like EGF repeat containing. (739 aa)
	MAML1	MAML1 isoform 1. (1016 aa)
	NOTCH4	NOTCH4 isoform 3. (2006 aa)
	DLL3	Delta like canonical Notch ligand 3. (618 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. (321 aa)
	NOTCH2	NOTCH2 isoform 1. (2612 aa)
	ENSPTRP00000075867	annotation not available (618 aa)
	JAG2	Jagged canonical Notch ligand 2. (1130 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	MAML3	MAML3 isoform 1. (1134 aa)
	HES5-2	Hes family bHLH transcription factor 5. (165 aa)
	ENSPTRP00000082196	annotation not available (376 aa)
	LFNG	LFNG isoform 5. (405 aa)
	ENSPTRP00000087746	annotation not available (429 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSPTRP00000032142	ENSPTRP00000063771	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta like canonical Notch ligand 3.	0.929
DLL1	DLL4	ENSPTRP00000032142	ENSPTRP00000070341	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
DLL1	DTX1	ENSPTRP00000032142	ENSPTRP00000009298	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Deltex E3 ubiquitin ligase 1.	0.613
DLL1	ENSPTRP00000082196	ENSPTRP00000032142	ENSPTRP00000082196	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.703
DLL1	ENSPTRP00000087746	ENSPTRP00000032142	ENSPTRP00000087746	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	annotation not available	0.703
DLL1	HES4	ENSPTRP00000032142	ENSPTRP00000046048	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 4.	0.480
DLL1	HES5	ENSPTRP00000032142	ENSPTRP00000040760	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.712
DLL1	HES5-2	ENSPTRP00000032142	ENSPTRP00000080637	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.712
DLL1	HEY1	ENSPTRP00000032142	ENSPTRP00000069126	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif 1.	0.737
DLL1	HEY2	ENSPTRP00000032142	ENSPTRP00000031710	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif 2.	0.573
DLL1	HEYL	ENSPTRP00000032142	ENSPTRP00000089331	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes related family bHLH transcription factor with YRPW motif like.	0.524
DLL1	JAG1	ENSPTRP00000032142	ENSPTRP00000022729	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.712
DLL1	JAG2	ENSPTRP00000032142	ENSPTRP00000075993	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Jagged canonical Notch ligand 2.	0.484
DLL1	LFNG	ENSPTRP00000032142	ENSPTRP00000082555	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LFNG isoform 5.	0.636
DLL1	LFNG-2	ENSPTRP00000032142	ENSPTRP00000016656	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.	0.636
DLL1	MAML1	ENSPTRP00000032142	ENSPTRP00000056639	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML1 isoform 1.	0.661
DLL1	MAML2	ENSPTRP00000032142	ENSPTRP00000007220	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.643
DLL1	MAML3	ENSPTRP00000032142	ENSPTRP00000079869	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MAML3 isoform 1.	0.618
DLL1	MFNG	ENSPTRP00000032142	ENSPTRP00000071868	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.	0.471
DLL1	NOTCH1	ENSPTRP00000032142	ENSPTRP00000036924	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NOTCH1 isoform 1.	0.998