STRINGSTRING
RET RET NRTN NRTN GFRA4 GFRA4 GFRA3 GFRA3 GFRAL GFRAL ENSPTRP00000034278 ENSPTRP00000034278 GFRA2 GFRA2 GDNF GDNF TINAGL1 TINAGL1 DOK4 DOK4 EFR3A EFR3A PSPN PSPN DOK6 DOK6 ARTN ARTN GFRA1 GFRA1 FAM83B FAM83B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
NRTNNRTN isoform 1. (197 aa)
GFRA4GFRA4 isoform 1. (269 aa)
GFRA3GDNF family receptor alpha 3. (400 aa)
GFRALGDNF family receptor alpha like. (394 aa)
ENSPTRP00000034278Platelet derived growth factor receptor like. (325 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
TINAGL1Tubulointerstitial nephritis antigen-like 1; Belongs to the peptidase C1 family. (467 aa)
DOK4Docking protein 4. (330 aa)
EFR3AEFR3A isoform 6. (848 aa)
PSPNPSPN isoform 2. (156 aa)
DOK6Docking protein 6. (331 aa)
ARTNARTN isoform 11. (235 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
FAM83BFamily with sequence similarity 83 member B. (1011 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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