STRINGSTRING
OPRD1 OPRD1 EDN2 EDN2 PROK1 PROK1 ENSPTRP00000002048 ENSPTRP00000002048 ADORA1 ADORA1 KISS1 KISS1 AGT AGT PRLHR PRLHR NPFF NPFF NTS NTS PMCH PMCH EDNRB EDNRB NMB NMB AGRP AGRP GAST GAST HCRT HCRT PPY PPY TAC4 TAC4 UTS2R UTS2R GRP GRP MC4R MC4R TACR1 TACR1 GPR39 GPR39 NMUR1 NMUR1 PDYN PDYN OXT OXT AVP AVP SSTR4 SSTR4 CK820_G0037244 CK820_G0037244 MCHR1 MCHR1 OXTR OXTR CCK CCK TRH TRH AADAC AADAC GHSR GHSR CCKAR CCKAR GNRHR GNRHR TACR3 TACR3 QRFPR QRFPR EDNRA EDNRA NPY2R NPY2R NPY1R NPY1R NPY5R NPY5R NLN NLN OTP OTP NMUR2 NMUR2 EDN1 EDN1 HCRTR2 HCRTR2 MRAP2 MRAP2 MCHR2 MCHR2 NMBR NMBR NPY NPY NPVF NPVF GNRH1 GNRH1 PNOC PNOC MBOAT4 MBOAT4 PENK PENK CHD7 CHD7 QRFP QRFP ANOS1 ANOS1 GRPR GRPR ATP6AP2 ATP6AP2 BRS3 BRS3 ACE ACE AVPR1B AVPR1B OPRM1 OPRM1 PYY PYY NPFFR2 NPFFR2 TACR2 TACR2 NPSR1 NPSR1 NPY4R NPY4R REN REN NMS NMS POMC POMC ENSPTRP00000052437 ENSPTRP00000052437 BDKRB1 BDKRB1 TRHR TRHR MRAP MRAP NPS NPS AVPR2 AVPR2 LEPR LEPR AVPR1A AVPR1A OPRK1 OPRK1 AGTR1 AGTR1 KNG1 KNG1 SST SST NPFFR1 NPFFR1 SSTR3 SSTR3 EDN3 EDN3 KISS1R KISS1R PRLH PRLH PROK2 PROK2 SSTR5 SSTR5 LEP LEP AGTR2 AGTR2 UTS2 UTS2 CCKBR CCKBR GHRL GHRL MLN MLN OPRL1 OPRL1 NMU NMU HCRTR1 HCRTR1 SSTR2 SSTR2 SIM1 SIM1 MC2R MC2R PROKR2 PROKR2 TAC1 TAC1 MLNR MLNR BDKRB2 BDKRB2 ENSPTRP00000087048 ENSPTRP00000087048 ECE1 ECE1 CORT CORT TAC3 TAC3 UTS2B UTS2B ENSPTRP00000092281 ENSPTRP00000092281 PROKR1 PROKR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
EDN2EDN2 isoform 1. (178 aa)
PROK1PROK1 isoform 1. (105 aa)
ENSPTRP00000002048LOW QUALITY PROTEIN: putative gonadotropin-releasing hormone II receptor. (91 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
KISS1KISS1 isoform 2. (138 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. (485 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NPFFPro-FMRFamide-related neuropeptide FF isoform X2. (113 aa)
NTSNTS isoform 1. (170 aa)
PMCHPro-MCH. (165 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
NMBNMB isoform 1. (154 aa)
AGRPAgouti related neuropeptide. (132 aa)
GASTGAST isoform 1. (101 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
PPYPancreatic polypeptide. (95 aa)
TAC4TAC4 isoform 4. (113 aa)
UTS2RUrotensin 2 receptor; Belongs to the G-protein coupled receptor 1 family. (389 aa)
GRPGastrin releasing peptide. (138 aa)
MC4RMelanocortin 4 receptor. (332 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
GPR39G protein-coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (453 aa)
NMUR1Neuromedin U receptor 1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PDYNPDYN isoform 1. (254 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
SSTR4Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family. (388 aa)
CK820_G0037244NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
MCHR1Melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. (422 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
CCKCCK isoform 2. (115 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
AADACArylacetamide deacetylase (Esterase). (399 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
TACR3Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (465 aa)
QRFPRPyroglutamylated RFamide peptide receptor; Belongs to the G-protein coupled receptor 1 family. (431 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPY5RNeuropeptide Y receptor type 5. (445 aa)
NLNNeurolysin (Metallopeptidase M3 family). (704 aa)
OTPOrthopedia homeobox. (325 aa)
NMUR2Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family. (415 aa)
EDN1EDN1 isoform 1. (212 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa)
MRAP2Melanocortin 2 receptor accessory protein 2. (205 aa)
MCHR2Melanin concentrating hormone receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
NPYNeuropeptide Y. (97 aa)
NPVFNeuropeptide VF precursor. (196 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)
PNOCPrepronociceptin. (176 aa)
MBOAT4MBOAT4 isoform 1; Belongs to the membrane-bound acyltransferase family. (435 aa)
PENKPENK isoform 3. (267 aa)
CHD7CHD7 isoform 1. (2997 aa)
QRFPQRFP isoform 1. (136 aa)
ANOS1Anosmin 1. (680 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 2. (350 aa)
BRS3Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
ACEAngiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. (1306 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (476 aa)
PYYPYY isoform 1. (95 aa)
NPFFR2NPFFR2 isoform 1; Belongs to the G-protein coupled receptor 1 family. (522 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (391 aa)
NPY4RNeuropeptide Y receptor Y4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
NMSNMS isoform 1. (153 aa)
POMCProopiomelanocortin. (268 aa)
ENSPTRP00000052437Gonadotropin releasing hormone 2, pseudogene. (103 aa)
BDKRB1Bradykinin receptor B1. (284 aa)
TRHRThyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (398 aa)
MRAPMelanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity). Belongs to the MRAP family. (172 aa)
NPSNeuropeptide S. (89 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
LEPRLeptin receptor. (1165 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
OPRK1Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (394 aa)
KNG1KNG1 isoform 2. (644 aa)
SSTSST isoform 1. (116 aa)
NPFFR1Neuropeptide FF receptor 1; Belongs to the G-protein coupled receptor 1 family. (431 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (418 aa)
EDN3EDN3 isoform 1. (238 aa)
KISS1RKISS1R isoform 1. (401 aa)
PRLHProlactin releasing hormone. (87 aa)
PROK2PROK2 isoform 2. (129 aa)
SSTR5SSTR5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (320 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
UTS2UTS2 isoform 2. (139 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (514 aa)
GHRLGHRL isoform 10. (117 aa)
MLNMLN isoform 2. (118 aa)
OPRL1OPRL1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NMUNMU isoform 2. (174 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SIM1Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (767 aa)
MC2RMelanocortin 2 receptor. (297 aa)
PROKR2Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
TAC1TAC1 isoform 1. (134 aa)
MLNRMotilin receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
BDKRB2B2 bradykinin receptor isoform X1. (391 aa)
ENSPTRP00000087048annotation not available (82 aa)
ECE1Endothelin converting enzyme 1. (770 aa)
CORTCENPS isoform 4. (143 aa)
TAC3TAC3 isoform 1. (121 aa)
UTS2BUrotensin 2 domain containing. (163 aa)
ENSPTRP00000092281annotation not available (136 aa)
PROKR1Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.