(57 nodes) Glycosphingolipid metabolism, and Glycosaminoglycan degradation network (Pan troglodytes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HPSE2	Heparanase 2 (inactive). (592 aa)
	MRGPRX2	Mas-related G-protein coupled receptor member X2; Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction; Belongs to the G-protein coupl [...] (329 aa)
	GLB1L2	Beta-galactosidase. (636 aa)
	GALC	Galactosylceramidase. (685 aa)
	GALNS	Galactosamine (N-acetyl)-6-sulfate sulfatase. (502 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (743 aa)
	GLB1L	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (654 aa)
	NEU2	Neuraminidase 2. (380 aa)
	GAL3ST1	Galactosylceramide sulfotransferase. (423 aa)
	NAGA	Alpha-galactosidase. (411 aa)
	ARSA	Arylsulfatase A. (509 aa)
	IDUA	IDUA isoform 1. (653 aa)
	ARSJ	Arylsulfatase family, member J. (598 aa)
	UGT8	UGT8 isoform 1; Belongs to the UDP-glycosyltransferase family. (541 aa)
	SCRG1	Stimulator of chondrogenesis 1. (98 aa)
	ARSI	Arylsulfatase family, member I. (569 aa)
	FUCA2	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (465 aa)
	SUMF2	Sulfatase modifying factor 2. (358 aa)
	CASD1	CAS1 domain containing 1. (933 aa)
	ARSH	ARSH isoform 1. (468 aa)
	GLA	Alpha-galactosidase. (429 aa)
	ARSF	Arylsulfatase F. (590 aa)
	ARSK	Arylsulfatase family, member K. (536 aa)
	PATE2	Prostate and testis expressed 2. (113 aa)
	ENSPTRP00000045056	Uncharacterized protein LOC739663. (133 aa)
	ARSG	Arylsulfatase G. (525 aa)
	XG	Xg blood group. (143 aa)
	GLB1L3	Beta-galactosidase. (653 aa)
	A4GALT	Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes; Belongs to the glycosyltransferase 32 family. (353 aa)
	ENSPTRP00000060732	annotation not available (524 aa)
	PATE3	Prostate and testis expressed 3. (98 aa)
	PGM1	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (580 aa)
	OGA	Meningioma expressed antigen 5 (Hyaluronidase). (946 aa)
	ENSPTRP00000065879	annotation not available (130 aa)
	GNS	GNS isoform 3. (584 aa)
	ARSB	Arylsulfatase B. (535 aa)
	NEU1	Sialidase 1 (Lysosomal sialidase). (417 aa)
	SUMF1	Sulfatase modifying factor 1. (374 aa)
	ARSD	Arylsulfatase D. (637 aa)
	HGSNAT	Heparan-alpha-glucosaminide N-acetyltransferase. (692 aa)
	CTSA	Carboxypeptidase; Belongs to the peptidase S10 family. (498 aa)
	SPAM1	Hyaluronidase. (511 aa)
	FAM9A	Family with sequence similarity 9 member A. (264 aa)
	GLB1	Beta-galactosidase. (699 aa)
	SGSH	N-sulfoglucosamine sulfohydrolase. (502 aa)
	NEU4	NEU4 isoform 10. (497 aa)
	IDS	T0188098 isoform 1. (550 aa)
	SUMF2-2	Sulfatase modifying factor 2. (358 aa)
	FUCA1	Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. (570 aa)
	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). (437 aa)
	HEXB	Beta-hexosaminidase. (557 aa)
	GLA-2	Galactosidase alpha. (429 aa)
	GUSB-2	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (651 aa)
	CELF6-2	CUGBP Elav-like family member 6 isoform X1. (538 aa)
	ST8SIA1	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. (356 aa)
	ENSPTRP00000093734	annotation not available (325 aa)
	NEU3	NEU3 isoform 1. (461 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A4GALT	CELF6-2	ENSPTRP00000055744	ENSPTRP00000089716	Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes; Belongs to the glycosyltransferase 32 family.	CUGBP Elav-like family member 6 isoform X1.	0.904
A4GALT	GLA	ENSPTRP00000055744	ENSPTRP00000039846	Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes; Belongs to the glycosyltransferase 32 family.	Alpha-galactosidase.	0.928
A4GALT	GLB1	ENSPTRP00000055744	ENSPTRP00000083644	Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes; Belongs to the glycosyltransferase 32 family.	Beta-galactosidase.	0.806
A4GALT	HEXB	ENSPTRP00000055744	ENSPTRP00000087394	Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes; Belongs to the glycosyltransferase 32 family.	Beta-hexosaminidase.	0.901
ARSA	ARSB	ENSPTRP00000025086	ENSPTRP00000067780	Arylsulfatase A.	Arylsulfatase B.	0.956
ARSA	ARSG	ENSPTRP00000025086	ENSPTRP00000045662	Arylsulfatase A.	Arylsulfatase G.	0.949
ARSA	ARSH	ENSPTRP00000025086	ENSPTRP00000037055	Arylsulfatase A.	ARSH isoform 1.	0.419
ARSA	ARSI	ENSPTRP00000025086	ENSPTRP00000029759	Arylsulfatase A.	Arylsulfatase family, member I.	0.548
ARSA	ARSJ	ENSPTRP00000025086	ENSPTRP00000028143	Arylsulfatase A.	Arylsulfatase family, member J.	0.551
ARSA	ARSK	ENSPTRP00000025086	ENSPTRP00000044544	Arylsulfatase A.	Arylsulfatase family, member K.	0.550
ARSA	ENSPTRP00000060732	ENSPTRP00000025086	ENSPTRP00000060732	Arylsulfatase A.	annotation not available	0.429
ARSA	ENSPTRP00000065879	ENSPTRP00000025086	ENSPTRP00000065879	Arylsulfatase A.	annotation not available	0.604
ARSA	GAL3ST1	ENSPTRP00000025086	ENSPTRP00000024539	Arylsulfatase A.	Galactosylceramide sulfotransferase.	0.461
ARSA	GALC	ENSPTRP00000025086	ENSPTRP00000011226	Arylsulfatase A.	Galactosylceramidase.	0.965
ARSA	GALNS	ENSPTRP00000025086	ENSPTRP00000014434	Arylsulfatase A.	Galactosamine (N-acetyl)-6-sulfate sulfatase.	0.805
ARSA	GLA	ENSPTRP00000025086	ENSPTRP00000039846	Arylsulfatase A.	Alpha-galactosidase.	0.947
ARSA	GLA-2	ENSPTRP00000025086	ENSPTRP00000087461	Arylsulfatase A.	Galactosidase alpha.	0.501
ARSA	GLB1	ENSPTRP00000025086	ENSPTRP00000083644	Arylsulfatase A.	Beta-galactosidase.	0.570
ARSA	GUSB-2	ENSPTRP00000025086	ENSPTRP00000089661	Arylsulfatase A.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.604
ARSA	IDUA	ENSPTRP00000025086	ENSPTRP00000027243	Arylsulfatase A.	IDUA isoform 1.	0.821