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| | MAD2L2 | MAD2 mitotic arrest deficient-like 2. (211 aa) |
| | RAD54L | RAD54L isoform 2. (747 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (859 aa) |
| | EXO1 | EXO1 isoform 1. (846 aa) |
| | FBH1 | FBXO18 isoform 3. (1096 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (642 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | POLD4 | T0118513 isoform 1. (107 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (238 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa) |
| | RFC5 | Replication factor C (Activator 1) 5, 36.5kDa. (340 aa) |
| | BRCA2 | Breast cancer 2, early onset. (3418 aa) |
| | RFC3 | Replication factor C (Activator 1) 3, 38kDa. (356 aa) |
| | FANCM | Fanconi anemia, complementation group M. (2048 aa) |
| | LRR1 | Leucine rich repeat protein 1. (414 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa) |
| | BLM | BLM isoform 1. (1417 aa) |
| | MEIOB | MEIOB isoform 2. (471 aa) |
| | RMI2 | Chromosome 16 open reading frame 75. (147 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1186 aa) |
| | ORC6 | Origin recognition complex, subunit 6. (252 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (184 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (552 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1844 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | RAD51C | RAD51C isoform 1. (377 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1249 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (998 aa) |
| | POLI | POLI isoform 2. (739 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | ORC2 | Origin recognition complex, subunit 2. (577 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | CDC45 | CDC45 isoform 5. (550 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (904 aa) |
| | TOPBP1 | Topoisomerase (DNA) II binding protein 1. (1522 aa) |
| | RFC1 | RFC1 isoform 4. (1199 aa) |
| | RAD1 | RAD1 isoform 1. (282 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | SLF1 | SLF1 isoform 2. (1058 aa) |
| | RAD50 | T0093306 isoform 4. (1312 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | RPA3 | Replication protein A3, 14kDa. (121 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | RFC2 | Replication factor C (Activator 1) 2, 40kDa. (354 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | ORC5 | Origin recognition complex, subunit 5. (435 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | FSBP | FSBP isoform 1. (910 aa) |
| | DSCC1 | Defective in sister chromatid cohesion 1 homolog. (435 aa) |
| | RMI1 | RMI1, RecQ mediated genome instability 1, homolog. (625 aa) |
| | POLE3 | Polymerase (DNA directed), epsilon 3 (P17 subunit). (147 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | WDHD1 | WDHD1 isoform 1. (1129 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | TIMELESS | Timeless circadian regulator. (1209 aa) |
| | XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2. (280 aa) |
| | MCM10 | Minichromosome maintenance complex component 10. (876 aa) |
| | TOP3A | DNA topoisomerase III alpha. (1001 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | CLSPN | CLSPN isoform 1. (1365 aa) |
| | DBF4 | DBF4 isoform 2. (673 aa) |
| | POLD2-2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | ATR | Ataxia telangiectasia and Rad3 related; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | DBF4B | DBF4 zinc finger B. (615 aa) |
| | TM4SF19 | TM4SF19 isoform 1. (299 aa) |
| | LDLRAD3-2 | Low density lipoprotein receptor class A domain containing 3. (77 aa) |
| | ATRIP | ATR interacting protein. (791 aa) |
| | ENSPTRP00000062077 | annotation not available (236 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | RAD50-2 | RAD50 double strand break repair protein. (1312 aa) |
| | PRIM2 | PRIM2 isoform 1. (158 aa) |
| | DNA2 | DNA2 isoform 3. (1024 aa) |
| | ENSPTRP00000065307 | annotation not available (623 aa) |
| | SPIB | T0182711 isoform 1. (1107 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1316 aa) |
| | ENSPTRP00000066250 | annotation not available (227 aa) |
| | ENSPTRP00000066694 | annotation not available (246 aa) |
| | RPA2 | Replication protein A2, 32kDa. (282 aa) |
| | CHEK1 | CHEK1 isoform 10. (485 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | RFC4 | Replication factor C (Activator 1) 4, 37kDa. (363 aa) |
| | ENSPTRP00000068474 | annotation not available (308 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | ENSPTRP00000069077 | annotation not available (82 aa) |
| | CDC7 | Cell division cycle 7 homolog. (574 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1884 aa) |
| | ENSPTRP00000070567 | annotation not available (277 aa) |
| | ENSPTRP00000071438 | annotation not available (278 aa) |
| | HUS1-2 | HUS1 checkpoint clamp component. (273 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | MCM8 | Minichromosome maintenance complex component 8; Belongs to the MCM family. (879 aa) |
| | ENSPTRP00000072741 | annotation not available (133 aa) |
| | ENSPTRP00000074557 | annotation not available (88 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | ENSPTRP00000076749 | annotation not available (243 aa) |
| | RECQL4 | RECQL4 isoform 3. (1208 aa) |
| | RAD51D | RAD51D isoform 8. (348 aa) |
| | GINS3 | GINS complex subunit 3. (255 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (495 aa) |
| | ENSPTRP00000079075 | annotation not available (560 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1143 aa) |
| | DBF4-2 | DBF4 zinc finger. (655 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | ENSPTRP00000081669 | annotation not available (319 aa) |
| | RAD51B | RAD51B isoform 1. (425 aa) |
| | ENSPTRP00000082174 | annotation not available (558 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | RFC2-2 | Replication factor C subunit 2. (354 aa) |
| | POLK | Polymerase (DNA directed) kappa. (897 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (417 aa) |
| | POLD3 | Polymerase (DNA-directed), delta 3, accessory subunit. (463 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1183 aa) |
| | MRE11 | MRE11 isoform 6; Belongs to the MRE11/RAD32 family. (762 aa) |
| | GINS1 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | CHTF18 | CTF18, chromosome transmission fidelity factor 18 homolog. (1133 aa) |
| | POLQ | POLQ isoform 1. (2731 aa) |
| | CK820_G0051860 | DDX11 isoform 28. (265 aa) |
| | LOC100609359 | DNA repair protein RAD52 homolog pseudogene. (338 aa) |
| | WRN | WRN RecQ like helicase. (1446 aa) |
| | ENSPTRP00000092083 | annotation not available (520 aa) |
