(16 nodes) Proteasome regulatory particle network (Pan troglodytes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMD7	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7. (324 aa)
	PSMD11	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11. (422 aa)
	PSMD3	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (534 aa)
	PSMD14	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14. (310 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
	PSMD6	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6. (441 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	PSMC2	Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family. (433 aa)
	USP14	Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibi [...] (493 aa)
	ENSPTRP00000064540	annotation not available (358 aa)
	ENSPTRP00000065241	annotation not available (350 aa)
	PSMD13	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13. (399 aa)
	PSMD12	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12. (480 aa)
	ENSPTRP00000086535	annotation not available (351 aa)
	PSMC4	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family. (421 aa)
	PSMC6	Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (411 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000064540	ENSPTRP00000065241	ENSPTRP00000064540	ENSPTRP00000065241	annotation not available	annotation not available	0.984
ENSPTRP00000064540	ENSPTRP00000086535	ENSPTRP00000064540	ENSPTRP00000086535	annotation not available	annotation not available	0.991
ENSPTRP00000064540	PSMC2	ENSPTRP00000064540	ENSPTRP00000033481	annotation not available	Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family.	0.992
ENSPTRP00000064540	PSMC4	ENSPTRP00000064540	ENSPTRP00000087250	annotation not available	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family.	0.996
ENSPTRP00000064540	PSMC6	ENSPTRP00000064540	ENSPTRP00000089732	annotation not available	Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family.	0.991
ENSPTRP00000064540	PSMD1	ENSPTRP00000064540	ENSPTRP00000022265	annotation not available	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.993
ENSPTRP00000064540	PSMD11	ENSPTRP00000064540	ENSPTRP00000015341	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 11.	0.994
ENSPTRP00000064540	PSMD12	ENSPTRP00000064540	ENSPTRP00000079666	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12.	0.992
ENSPTRP00000064540	PSMD13	ENSPTRP00000064540	ENSPTRP00000071738	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 13.	0.995
ENSPTRP00000064540	PSMD14	ENSPTRP00000064540	ENSPTRP00000021491	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14.	0.996
ENSPTRP00000064540	PSMD2	ENSPTRP00000064540	ENSPTRP00000026991	annotation not available	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.993
ENSPTRP00000064540	PSMD3	ENSPTRP00000064540	ENSPTRP00000015526	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3.	0.993
ENSPTRP00000064540	PSMD6	ENSPTRP00000064540	ENSPTRP00000026037	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 6.	0.996
ENSPTRP00000064540	PSMD7	ENSPTRP00000064540	ENSPTRP00000014246	annotation not available	Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7.	0.993
ENSPTRP00000064540	USP14	ENSPTRP00000064540	ENSPTRP00000055013	annotation not available	Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibi [...]	0.974
ENSPTRP00000065241	ENSPTRP00000064540	ENSPTRP00000065241	ENSPTRP00000064540	annotation not available	annotation not available	0.984
ENSPTRP00000065241	ENSPTRP00000086535	ENSPTRP00000065241	ENSPTRP00000086535	annotation not available	annotation not available	0.988
ENSPTRP00000065241	PSMC2	ENSPTRP00000065241	ENSPTRP00000033481	annotation not available	Proteasome (Prosome, macropain) 26S subunit, ATPase, 2; Belongs to the AAA ATPase family.	0.969
ENSPTRP00000065241	PSMC4	ENSPTRP00000065241	ENSPTRP00000087250	annotation not available	Proteasome (Prosome, macropain) 26S subunit, ATPase, 4; Belongs to the AAA ATPase family.	0.994
ENSPTRP00000065241	PSMC6	ENSPTRP00000065241	ENSPTRP00000089732	annotation not available	Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family.	0.983