(11 nodes) SUMO is conjugated to E1 (UBA2:SAE1), and PINIT domain network (Pan troglodytes)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (198 aa)
	PIAS4	Protein inhibitor of activated STAT protein 4. (510 aa)
	UBA2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa)
	SAE1-2	Ubiquitin-like 1-activating enzyme E1A. (346 aa)
	SUMO2	Small ubiquitin-related modifier. (145 aa)
	SAE1	SUMO1 activating enzyme subunit 1. (346 aa)
	PIAS1	Protein inhibitor of activated STAT 1. (653 aa)
	LOC107967200	SUMO-activating enzyme subunit 2 pseudogene. (344 aa)
	SUMO1-2	Small ubiquitin-related modifier. (82 aa)
	SUMO3-2	Small ubiquitin-related modifier. (103 aa)
	SUMO1	SUMO1 isoform 3. (146 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107967200	PIAS1	ENSPTRP00000083941	ENSPTRP00000079822	SUMO-activating enzyme subunit 2 pseudogene.	Protein inhibitor of activated STAT 1.	0.431
LOC107967200	PIAS4	ENSPTRP00000083941	ENSPTRP00000017489	SUMO-activating enzyme subunit 2 pseudogene.	Protein inhibitor of activated STAT protein 4.	0.416
LOC107967200	SAE1	ENSPTRP00000083941	ENSPTRP00000077899	SUMO-activating enzyme subunit 2 pseudogene.	SUMO1 activating enzyme subunit 1.	0.994
LOC107967200	SAE1-2	ENSPTRP00000083941	ENSPTRP00000019221	SUMO-activating enzyme subunit 2 pseudogene.	Ubiquitin-like 1-activating enzyme E1A.	0.994
LOC107967200	SUMO1	ENSPTRP00000083941	ENSPTRP00000088953	SUMO-activating enzyme subunit 2 pseudogene.	SUMO1 isoform 3.	0.985
LOC107967200	SUMO1-2	ENSPTRP00000083941	ENSPTRP00000084189	SUMO-activating enzyme subunit 2 pseudogene.	Small ubiquitin-related modifier.	0.985
LOC107967200	SUMO2	ENSPTRP00000083941	ENSPTRP00000060506	SUMO-activating enzyme subunit 2 pseudogene.	Small ubiquitin-related modifier.	0.833
LOC107967200	SUMO3-2	ENSPTRP00000083941	ENSPTRP00000086080	SUMO-activating enzyme subunit 2 pseudogene.	Small ubiquitin-related modifier.	0.950
LOC107967200	UBA2	ENSPTRP00000083941	ENSPTRP00000018512	SUMO-activating enzyme subunit 2 pseudogene.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.544
LOC107967200	UBE2I	ENSPTRP00000083941	ENSPTRP00000012969	SUMO-activating enzyme subunit 2 pseudogene.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.971
PIAS1	LOC107967200	ENSPTRP00000079822	ENSPTRP00000083941	Protein inhibitor of activated STAT 1.	SUMO-activating enzyme subunit 2 pseudogene.	0.431
PIAS1	PIAS4	ENSPTRP00000079822	ENSPTRP00000017489	Protein inhibitor of activated STAT 1.	Protein inhibitor of activated STAT protein 4.	0.497
PIAS1	SAE1	ENSPTRP00000079822	ENSPTRP00000077899	Protein inhibitor of activated STAT 1.	SUMO1 activating enzyme subunit 1.	0.571
PIAS1	SAE1-2	ENSPTRP00000079822	ENSPTRP00000019221	Protein inhibitor of activated STAT 1.	Ubiquitin-like 1-activating enzyme E1A.	0.571
PIAS1	SUMO1	ENSPTRP00000079822	ENSPTRP00000088953	Protein inhibitor of activated STAT 1.	SUMO1 isoform 3.	0.950
PIAS1	SUMO1-2	ENSPTRP00000079822	ENSPTRP00000084189	Protein inhibitor of activated STAT 1.	Small ubiquitin-related modifier.	0.974
PIAS1	SUMO2	ENSPTRP00000079822	ENSPTRP00000060506	Protein inhibitor of activated STAT 1.	Small ubiquitin-related modifier.	0.867
PIAS1	SUMO3-2	ENSPTRP00000079822	ENSPTRP00000086080	Protein inhibitor of activated STAT 1.	Small ubiquitin-related modifier.	0.903
PIAS1	UBA2	ENSPTRP00000079822	ENSPTRP00000018512	Protein inhibitor of activated STAT 1.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.431
PIAS1	UBE2I	ENSPTRP00000079822	ENSPTRP00000012969	Protein inhibitor of activated STAT 1.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.982