39 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARN	PARN isoform 1. (639 aa)
	EXOSC7	Exosome component 7. (291 aa)
	PDE12	Phosphodiesterase 12. (609 aa)
	CNOT6L	CCR4-NOT transcription complex subunit 6 like. (562 aa)
	CNOT8	CCR4-NOT transcription complex, subunit 8. (292 aa)
	EXOSC4	Exosome component 4. (245 aa)
	EXOSC3	Exosome complex exonuclease RRP40. (275 aa)
	DIS3L2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (887 aa)
	EXOSC5	Exosome component 5. (235 aa)
	ERI3	ERI1 exoribonuclease family member 3. (337 aa)
	ERI1	Exoribonuclease 1. (271 aa)
	ENSPTRP00000091556	annotation not available (277 aa)
	ENSPTRP00000090981	annotation not available (244 aa)
	USB1	U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (247 aa)
	CK820_G0044476	CNOT6 isoform 4. (464 aa)
	PNLDC1	PARN like, ribonuclease domain containing 1. (531 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (784 aa)
	TOE1	Target of EGR1, member 1 (Nuclear). (523 aa)
	EXD2	Exonuclease 3'-5' domain containing 2. (621 aa)
	ISG20L2	Interferon stimulated exonuclease gene 20kDa-like 2. (352 aa)
	CNOT7	CCR4-NOT transcription complex, subunit 7. (285 aa)
	NOCT	CCR4 carbon catabolite repression 4-like. (431 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
	EXOSC2-2	Exosome component 2. (293 aa)
	CNOT6	CCR4-NOT transcription complex, subunit 6. (557 aa)
	ENSPTRP00000068740	annotation not available (675 aa)
	EXOSC9	Exosome component 9. (456 aa)
	EXOSC10	EXOSC10 isoform 1. (869 aa)
	CK820_G0038659	CNOT7 isoform 10. (245 aa)
	ISG20	Interferon stimulated exonuclease gene 20kDa. (181 aa)
	ERI2	ERI1 exoribonuclease family member 2. (598 aa)
	DIS3	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
	EXOSC2	Exosome component 2. (293 aa)
	ANGEL2	ANGEL2 isoform 3. (544 aa)
	LRRC27	LRRC27 isoform 3. (530 aa)
	REXO2	REX2, RNA exonuclease 2 homolog. (237 aa)
	ANGEL1	ANGEL1 isoform 1. (670 aa)
	DIS3L	DIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1054 aa)
	XRN2	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGEL2	CNOT8	ENSPTRP00000003315	ENSPTRP00000029810	ANGEL2 isoform 3.	CCR4-NOT transcription complex, subunit 8.	0.491
ANGEL2	TOE1	ENSPTRP00000003315	ENSPTRP00000084060	ANGEL2 isoform 3.	Target of EGR1, member 1 (Nuclear).	0.596
CK820_G0038659	CK820_G0044476	ENSPTRP00000061148	ENSPTRP00000087154	CNOT7 isoform 10.	CNOT6 isoform 4.	0.963
CK820_G0038659	CNOT6	ENSPTRP00000061148	ENSPTRP00000069359	CNOT7 isoform 10.	CCR4-NOT transcription complex, subunit 6.	0.976
CK820_G0038659	CNOT6L	ENSPTRP00000061148	ENSPTRP00000027832	CNOT7 isoform 10.	CCR4-NOT transcription complex subunit 6 like.	0.963
CK820_G0038659	CNOT7	ENSPTRP00000061148	ENSPTRP00000078280	CNOT7 isoform 10.	CCR4-NOT transcription complex, subunit 7.	0.543
CK820_G0038659	CNOT8	ENSPTRP00000061148	ENSPTRP00000029810	CNOT7 isoform 10.	CCR4-NOT transcription complex, subunit 8.	0.797
CK820_G0038659	ENSPTRP00000090981	ENSPTRP00000061148	ENSPTRP00000090981	CNOT7 isoform 10.	annotation not available	0.547
CK820_G0038659	ENSPTRP00000091556	ENSPTRP00000061148	ENSPTRP00000091556	CNOT7 isoform 10.	annotation not available	0.544
CK820_G0038659	LRRC27	ENSPTRP00000061148	ENSPTRP00000005408	CNOT7 isoform 10.	LRRC27 isoform 3.	0.640
CK820_G0038659	NOCT	ENSPTRP00000061148	ENSPTRP00000075575	CNOT7 isoform 10.	CCR4 carbon catabolite repression 4-like.	0.596
CK820_G0038659	PDE12	ENSPTRP00000061148	ENSPTRP00000025996	CNOT7 isoform 10.	Phosphodiesterase 12.	0.581
CK820_G0044476	CK820_G0038659	ENSPTRP00000087154	ENSPTRP00000061148	CNOT6 isoform 4.	CNOT7 isoform 10.	0.963
CK820_G0044476	CNOT6	ENSPTRP00000087154	ENSPTRP00000069359	CNOT6 isoform 4.	CCR4-NOT transcription complex, subunit 6.	0.954
CK820_G0044476	CNOT6L	ENSPTRP00000087154	ENSPTRP00000027832	CNOT6 isoform 4.	CCR4-NOT transcription complex subunit 6 like.	0.543
CK820_G0044476	CNOT7	ENSPTRP00000087154	ENSPTRP00000078280	CNOT6 isoform 4.	CCR4-NOT transcription complex, subunit 7.	0.963
CK820_G0044476	CNOT8	ENSPTRP00000087154	ENSPTRP00000029810	CNOT6 isoform 4.	CCR4-NOT transcription complex, subunit 8.	0.969
CK820_G0044476	ENSPTRP00000090981	ENSPTRP00000087154	ENSPTRP00000090981	CNOT6 isoform 4.	annotation not available	0.963
CK820_G0044476	ENSPTRP00000091556	ENSPTRP00000087154	ENSPTRP00000091556	CNOT6 isoform 4.	annotation not available	0.856
CK820_G0044476	PAN2	ENSPTRP00000087154	ENSPTRP00000074921	CNOT6 isoform 4.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.453