STRINGSTRING
RUVBL1 RUVBL1 TAF1 TAF1 GTF2A1 GTF2A1 HNRNPU HNRNPU TAF7L TAF7L ZNHIT6 ZNHIT6 NOP58 NOP58 ENSPTRP00000078721 ENSPTRP00000078721 AR AR ERCC1 ERCC1 ERCC4 ERCC4 FOXF2 FOXF2 NOLC1 NOLC1 TCF4 TCF4 EDF1 EDF1 ESR1 ESR1 GTF2F1 GTF2F1 DRAP1 DRAP1 GTF2A2 GTF2A2 TP53 TP53 CTDP1 CTDP1 TBP TBP FBL FBL RUVBL2 RUVBL2 LOC736189 LOC736189 GTF2A2-2 GTF2A2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
GTF2A1General transcription factor IIA, 1, 19/37kDa. (366 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (825 aa)
TAF7LTATA-box binding protein associated factor 7 like. (457 aa)
ZNHIT6Zinc finger, HIT-type containing 6. (470 aa)
NOP58NOP58 ribonucleoprotein homolog. (536 aa)
ENSPTRP00000078721annotation not available (91 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (912 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
ERCC4Excision repair cross-complementing rodent repair deficiency, complementation group 4. (916 aa)
FOXF2FOXF2 isoform 1. (444 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (701 aa)
TCF4Transcription factor 4. (773 aa)
EDF1Endothelial differentiation related factor 1. (141 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (517 aa)
DRAP1DR1-associated protein 1 (Negative cofactor 2 alpha). (205 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (961 aa)
TBPTBP isoform 1. (336 aa)
FBLFBL isoform 1. (336 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
LOC736189FBL isoform 7. (299 aa)
GTF2A2-2General transcription factor IIA subunit 2. (72 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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