node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | ESR1 | ENSPTRP00000076864 | ENSPTRP00000031932 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.841 |
AR | GTF2F1 | ENSPTRP00000076864 | ENSPTRP00000017625 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. | 0.590 |
AR | TAF1 | ENSPTRP00000076864 | ENSPTRP00000090345 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Transcription initiation factor TFIID subunit. | 0.403 |
AR | TP53 | ENSPTRP00000076864 | ENSPTRP00000014836 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.713 |
CTDP1 | GTF2F1 | ENSPTRP00000017217 | ENSPTRP00000017625 | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. | 0.996 |
DRAP1 | TBP | ENSPTRP00000006727 | ENSPTRP00000058203 | DR1-associated protein 1 (Negative cofactor 2 alpha). | TBP isoform 1. | 0.870 |
EDF1 | TBP | ENSPTRP00000036947 | ENSPTRP00000058203 | Endothelial differentiation related factor 1. | TBP isoform 1. | 0.782 |
ENSPTRP00000078721 | GTF2A1 | ENSPTRP00000078721 | ENSPTRP00000089729 | annotation not available | General transcription factor IIA, 1, 19/37kDa. | 0.948 |
ENSPTRP00000078721 | GTF2A2 | ENSPTRP00000078721 | ENSPTRP00000012186 | annotation not available | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | 0.546 |
ENSPTRP00000078721 | GTF2A2-2 | ENSPTRP00000078721 | ENSPTRP00000076436 | annotation not available | General transcription factor IIA subunit 2. | 0.558 |
ENSPTRP00000078721 | GTF2F1 | ENSPTRP00000078721 | ENSPTRP00000017625 | annotation not available | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. | 0.868 |
ENSPTRP00000078721 | TAF1 | ENSPTRP00000078721 | ENSPTRP00000090345 | annotation not available | Transcription initiation factor TFIID subunit. | 0.770 |
ENSPTRP00000078721 | TAF7L | ENSPTRP00000078721 | ENSPTRP00000080258 | annotation not available | TATA-box binding protein associated factor 7 like. | 0.651 |
ENSPTRP00000078721 | TBP | ENSPTRP00000078721 | ENSPTRP00000058203 | annotation not available | TBP isoform 1. | 0.907 |
ERCC1 | ERCC4 | ENSPTRP00000076815 | ENSPTRP00000053757 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Excision repair cross-complementing rodent repair deficiency, complementation group 4. | 0.999 |
ERCC1 | TP53 | ENSPTRP00000076815 | ENSPTRP00000014836 | ERCC excision repair 1, endonuclease non-catalytic subunit. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.553 |
ERCC4 | ERCC1 | ENSPTRP00000053757 | ENSPTRP00000076815 | Excision repair cross-complementing rodent repair deficiency, complementation group 4. | ERCC excision repair 1, endonuclease non-catalytic subunit. | 0.999 |
ESR1 | AR | ENSPTRP00000031932 | ENSPTRP00000076864 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.841 |
ESR1 | GTF2A1 | ENSPTRP00000031932 | ENSPTRP00000089729 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | General transcription factor IIA, 1, 19/37kDa. | 0.644 |
ESR1 | GTF2F1 | ENSPTRP00000031932 | ENSPTRP00000017625 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. | 0.451 |