STRINGSTRING
ENSPTRP00000085680 ENSPTRP00000085680 ENSPTRP00000086934 ENSPTRP00000086934 KCNH6 KCNH6 KCNQ1 KCNQ1 HCN2 HCN2 ENSPTRP00000088766 ENSPTRP00000088766 SCN1B SCN1B FGF12 FGF12 ATP1A1 ATP1A1 CK820_G0057017 CK820_G0057017 MTOR MTOR CLDN19 CLDN19 GPR88 GPR88 ANK3 ANK3 SCN3B SCN3B CACNA1C CACNA1C KCNA1 KCNA1 KCNA5 KCNA5 KCNJ8 KCNJ8 PKP2 PKP2 P2RX4 P2RX4 AKAP6 AKAP6 GJD2 GJD2 HCN4 HCN4 CHRNB4 CHRNB4 CACNA1H CACNA1H YWHAE YWHAE P2RX1 P2RX1 SCN4A SCN4A KCNJ2 KCNJ2 TRPM4 TRPM4 FKBP1B FKBP1B KCNJ3 KCNJ3 KCNH7 KCNH7 SCN1A SCN1A SCN9A SCN9A CHRNA1 CHRNA1 SLC4A3 SLC4A3 KCNE4 KCNE4 SNTA1 SNTA1 KCNB1 KCNB1 KCNE1 KCNE1 YWHAH YWHAH CAV3 CAV3 SCN11A SCN11A KCNN2 KCNN2 GLRA1 GLRA1 GRIK2 GRIK2 AKAP7 AKAP7 CLCN1 CLCN1 SCN7A SCN7A SCN8A SCN8A SCN10A SCN10A CACNB2 CACNB2 ANK2 ANK2 KCNH2 KCNH2 GNAQ GNAQ P2RX7 P2RX7 CNTNAP1 CNTNAP1 KCNE2 KCNE2 SCN3A SCN3A CACNB4 CACNB4 CACNA1I CACNA1I KCNE5 KCNE5 KCND3 KCND3 KCNE3 KCNE3 P2RX3 P2RX3 CK820_G0042363 CK820_G0042363 KCNA2 KCNA2 LOC737549 LOC737549 NEDD4L NEDD4L CLCN1-2 CLCN1-2 SLC8A1 SLC8A1 RYR2 RYR2 MYH14 MYH14 DRD1 DRD1 CACNA1G CACNA1G LOC736481 LOC736481 KCNIP2 KCNIP2 KCNMB3 KCNMB3 KCND2 KCND2 NRCAM NRCAM ENSPTRP00000068927 ENSPTRP00000068927 SCN5A SCN5A DMD DMD ENSPTRP00000070111 ENSPTRP00000070111 GPD1L GPD1L CACNA2D1 CACNA2D1 SCN2B SCN2B KCNMB4 KCNMB4 GNA11 GNA11 SCN2A SCN2A ENSPTRP00000075494 ENSPTRP00000075494 ENSPTRP00000075783 ENSPTRP00000075783 CACNA1D CACNA1D ENSPTRP00000077377 ENSPTRP00000077377 NTRK2 NTRK2 NUP155 NUP155 KCNC2 KCNC2 CK820_G0013720 CK820_G0013720 SRI SRI SRI-2 SRI-2 ATP1A2 ATP1A2 ENSPTRP00000082268 ENSPTRP00000082268 ENSPTRP00000082446 ENSPTRP00000082446 DMD-2 DMD-2 LOC459638 LOC459638 ENSPTRP00000090501 ENSPTRP00000090501 SCN4B SCN4B KCNMB2 KCNMB2 GNA14 GNA14 ENSPTRP00000091918 ENSPTRP00000091918 CK820_G0029100 CK820_G0029100 ENSPTRP00000092784 ENSPTRP00000092784 KCNJ5 KCNJ5 GNA15 GNA15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPTRP00000085680annotation not available (88 aa)
ENSPTRP00000086934annotation not available (467 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (775 aa)
ENSPTRP00000088766annotation not available (199 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
CK820_G0057017CLN3 isoform 55. (42 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
GPR88G protein-coupled receptor 88. (384 aa)
ANK3ANK3 isoform 5. (4377 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
KCNA1Potassium voltage-gated channel, shaker-related subfamily, member 1 (Episodic ataxia with myokymia); Belongs to the potassium channel family. (495 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
KCNJ8Potassium inwardly-rectifying channel, subfamily J, member 8. (424 aa)
PKP2PKP2 isoform 1. (837 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (346 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (498 aa)
CACNA1HCACNA1H isoform 1. (2240 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1196 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1988 aa)
CHRNA1Cholinergic receptor, nicotinic, alpha 1 (Muscle). (482 aa)
SLC4A3Anion exchange protein. (1259 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
SNTA1Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component). (505 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
KCNE1KCNE1B isoform 1. (132 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (246 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1792 aa)
KCNN2Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2. (843 aa)
GLRA1GLRA1 isoform 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
CLCN1Chloride channel protein. (989 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1682 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1991 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ANK2ANK2 isoform 1. (3957 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
GNAQGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
KCNE2KCNE2 isoform 1. (123 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2223 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
KCND3Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (655 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
KCNA2KCNA2 isoform 1; Belongs to the potassium channel family. (356 aa)
LOC737549Battenin. (418 aa)
NEDD4LNEDD4L isoform 6. (1254 aa)
CLCN1-2Chloride voltage-gated channel 1. (989 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
RYR2RYR2 isoform 1. (4941 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
LOC736481Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (279 aa)
KCND2Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family. (630 aa)
NRCAMNeuronal cell adhesion molecule. (1304 aa)
ENSPTRP00000068927annotation not available (480 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
DMDDMD isoform 3. (3685 aa)
ENSPTRP00000070111annotation not available (324 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
KCNMB4Potassium large conductance calcium-activated channel, subfamily M, beta member 4. (210 aa)
GNA11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
ENSPTRP00000075494annotation not available (194 aa)
ENSPTRP00000075783annotation not available (149 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
ENSPTRP00000077377annotation not available (149 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
NUP155Nucleoporin 155kDa. (1391 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
CK820_G0013720HCN2 isoform 1. (847 aa)
SRISRI isoform 1. (205 aa)
SRI-2SRI isoform 5. (237 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ENSPTRP00000082268annotation not available (246 aa)
ENSPTRP00000082446annotation not available (194 aa)
DMD-2Dystrophin. (643 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000090501annotation not available (192 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (263 aa)
GNA14Guanine nucleotide binding protein (G protein), alpha 14. (355 aa)
ENSPTRP00000091918annotation not available (454 aa)
CK820_G0029100SRI isoform 2. (98 aa)
ENSPTRP00000092784annotation not available (75 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GNA15G protein subunit alpha 15. (374 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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