STRINGSTRING
NOTCH4 NOTCH4 FOXC2 FOXC2 CTNNB1 CTNNB1 NRARP NRARP ENG ENG TBX20 TBX20 SRF SRF EDN1 EDN1 SFRP2 SFRP2 EDNRA EDNRA KDR KDR PLXND1 PLXND1 GBX2 GBX2 IHH IHH GNA13 GNA13 NRP1 NRP1 RBM15 RBM15 COL4A1 COL4A1 NFATC4 NFATC4 LEF1 LEF1 ACVR1 ACVR1 SHH SHH FGF8 FGF8 TGFBR2 TGFBR2 DLL4 DLL4 GDF2 GDF2 SEMA3E SEMA3E STK4 STK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH4NOTCH4 isoform 3. (2006 aa)
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENGENG isoform 1. (658 aa)
TBX20T-box transcription factor 20. (447 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
EDN1EDN1 isoform 1. (212 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PLXND1PLXND1 isoform 1. (1925 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
GNA13Guanine nucleotide binding protein (G protein), alpha 13. (377 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
RBM15RNA binding motif protein 15. (977 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
GDF2GDF2 isoform 1. (429 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.