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FOXC2 FOXC2 OSR2 OSR2 LGR4 LGR4 FOXD1 FOXD1 ROBO2 ROBO2 PAX2 PAX2 STAT1 STAT1 BCL2 BCL2 WT1 WT1 PTCH1 PTCH1 ITGA8 ITGA8 PAX8 PAX8 LOC743215 LOC743215 CK820_G0054628 CK820_G0054628 FGF10 FGF10 SPRY1 SPRY1 NKX3-1 NKX3-1 BMP4-2 BMP4-2 HES5-2 HES5-2 PDGFRB PDGFRB TFAP2B TFAP2B ENSPTRP00000077262 ENSPTRP00000077262 UMOD UMOD GDF6 GDF6 WNT9B-2 WNT9B-2 SHH SHH FGF8 FGF8 POU3F3 POU3F3 AGTR2 AGTR2 AQP2 AQP2 ENSPTRP00000070319 ENSPTRP00000070319 SIX1 SIX1 ENSPTRP00000069764 ENSPTRP00000069764 GREB1L GREB1L FBN1 FBN1 BASP1 BASP1 SMO-2 SMO-2 ENSPTRP00000067500 ENSPTRP00000067500 CK820_G0056924 CK820_G0056924 GATA3 GATA3 SALL1 SALL1 HES1 HES1 FMN1 FMN1 WNT7B WNT7B WNT4 WNT4 WNT9B WNT9B LHX1 LHX1 KIF26B KIF26B GDNF GDNF NIPBL NIPBL FRAS1 FRAS1 CTNNB1 CTNNB1 SIX4 SIX4 APH1A APH1A HES5 HES5 CITED1 CITED1 CALB1 CALB1 RDH10 RDH10 EYA1 EYA1 SOX17 SOX17 AKR1B1 AKR1B1 SMO SMO GLI3 GLI3 AQP1 AQP1 HOXA11 HOXA11 TCF21 TCF21 IRX1 IRX1 IRX2 IRX2 PKD2 PKD2 LAMB2 LAMB2 PDGFB PDGFB BMP7 BMP7 SIX2 SIX2 OSR1 OSR1 SMAD4 SMAD4 GREB1 GREB1 FOXJ1 FOXJ1 SOX9 SOX9 NF1 NF1 IRX3 IRX3 SOX8 SOX8 CTSH CTSH BMP4 BMP4 GDF11 GDF11 HOXC11 HOXC11 ACAT1 ACAT1 DLG5 DLG5 RET RET CD34 CD34 NPHS2 NPHS2 ID3 ID3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXC2Forkhead box C2 (MFH-1, mesenchyme forkhead 1). (501 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
LGR4LGR4 isoform 2. (951 aa)
FOXD1FOXD1 isoform 1. (439 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
PAX2PAX2 isoform 1. (417 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
WT1WT1 transcription factor. (514 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
PAX8PAX8 isoform 1. (456 aa)
LOC743215AKR1B1 isoform 13. (294 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SPRY1Sprouty homolog 1, antagonist of FGF signaling. (319 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
HES5-2Hes family bHLH transcription factor 5. (165 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TFAP2BTranscription factor AP-2 beta. (467 aa)
ENSPTRP00000077262annotation not available (314 aa)
UMODUMOD isoform 1. (690 aa)
GDF6Growth differentiation factor 6. (455 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
POU3F3POU domain protein. (476 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
AQP2AQP2 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
ENSPTRP00000070319annotation not available (244 aa)
SIX1SIX homeobox 1. (284 aa)
ENSPTRP00000069764annotation not available (1213 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
FBN1FBN1 isoform 1. (2871 aa)
BASP1Brain abundant, membrane attached signal protein 1. (226 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
ENSPTRP00000067500annotation not available (264 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
GATA3GATA binding protein 3. (444 aa)
SALL1SALL1 isoform 2. (1326 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
FMN1FMN1 isoform 1. (1425 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
KIF26BKIF26B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
NIPBLNipped-B protein. (2804 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4012 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
SIX4SIX homeobox 4. (781 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
HES5Hes family bHLH transcription factor 5. (165 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
CALB1CALB1 isoform 3. (261 aa)
RDH10Retinol dehydrogenase 10 (All-trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SOX17SOX17 isoform 1. (416 aa)
AKR1B1Aldo-keto reductase family 1, member B1 (Aldose reductase). (316 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
HOXA11HOXA11 isoform 2. (313 aa)
TCF21Transcription factor 21. (179 aa)
IRX1Iroquois homeobox 1. (480 aa)
IRX2Iroquois homeobox 2. (471 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
LAMB2Laminin, beta 2 (Laminin S). (1798 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SIX2SIX homeobox 2. (291 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
FOXJ1FOXJ1 isoform 1. (421 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
NF1Neurofibromin 1. (2839 aa)
IRX3Iroquois homeobox 3. (500 aa)
SOX8SOX8 isoform 1. (446 aa)
CTSHCTSH isoform 11; Belongs to the peptidase C1 family. (335 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF11GDF11 isoform 1. (407 aa)
HOXC11HOXC11 isoform 1. (304 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
CD34CD34 isoform 1. (328 aa)
NPHS2NPHS2 stomatin family member, podocin. (383 aa)
ID3Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. (119 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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