STRINGSTRING
TMEM59L TMEM59L SMAD4 SMAD4 GREB1 GREB1 FOXD1 FOXD1 BMP4 BMP4 WNT1 WNT1 SOX9 SOX9 PAX2 PAX2 BCL2 BCL2 LAMA5 LAMA5 DCHS1 DCHS1 WT1 WT1 PTCH1 PTCH1 HS3ST3A1 HS3ST3A1 NPNT NPNT PAX8 PAX8 BMP4-2 BMP4-2 WNT6 WNT6 CTNNBIP1 CTNNBIP1 ENSPTRP00000077262 ENSPTRP00000077262 WNT9B-2 WNT9B-2 SHH SHH FGF8 FGF8 SIX1 SIX1 ENSPTRP00000069764 ENSPTRP00000069764 GREB1L GREB1L FGF2 FGF2 DLG1 DLG1 ILK ILK SALL1 SALL1 WNT4 WNT4 PBX1 PBX1 WNT9B WNT9B PGF PGF HOXD11 HOXD11 LHX1 LHX1 GDNF GDNF CTNNB1 CTNNB1 HS3ST3B1 HS3ST3B1 CITED1 CITED1 EYA1 EYA1 GLI3 GLI3 HOXA11 HOXA11 TCF21 TCF21 FGF1 FGF1 ADAMTS16 ADAMTS16 PKD2 PKD2 GZF1 GZF1 BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM59LTransmembrane protein 59-like. (343 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
FOXD1FOXD1 isoform 1. (439 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
PAX2PAX2 isoform 1. (417 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LAMA5Laminin, alpha 5. (2203 aa)
DCHS1DCHS1 isoform 1. (3298 aa)
WT1WT1 transcription factor. (514 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (374 aa)
NPNTNPNT isoform 10. (611 aa)
PAX8PAX8 isoform 1. (456 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTNNBIP1Catenin, beta interacting protein 1. (81 aa)
ENSPTRP00000077262annotation not available (314 aa)
WNT9B-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SIX1SIX homeobox 1. (284 aa)
ENSPTRP00000069764annotation not available (1213 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. (288 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ILKIntegrin-linked kinase. (533 aa)
SALL1SALL1 isoform 2. (1326 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PBX1Pre-B-cell leukemia homeobox 1. (486 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
HOXD11HOXD11 isoform 2. (339 aa)
LHX1LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity). (406 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
HOXA11HOXA11 isoform 2. (313 aa)
TCF21Transcription factor 21. (179 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
GZF1GDNF inducible zinc finger protein 1. (711 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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