STRINGSTRING
FAM162A FAM162A MTOR MTOR MTHFR MTHFR PINK1 PINK1 OPRD1 OPRD1 PLK3 PLK3 AK4 AK4 CLCA1 CLCA1 VCAM1 VCAM1 CHRNB2 CHRNB2 LMNA LMNA USF1 USF1 DDR2 DDR2 PTGS2 PTGS2 TGFB2 TGFB2 CK820_G0023253 CK820_G0023253 SIRT1 SIRT1 STOX1 STOX1 DDIT4 DDIT4 PLAU PLAU PDLIM1 PDLIM1 HIF1AN HIF1AN BNIP3 BNIP3 TH TH ADM ADM CAT CAT UCP2 UCP2 UCP3 UCP3 BIRC2 BIRC2 CRYAB CRYAB IL18 IL18 HYOU1 HYOU1 TIGAR TIGAR KCNA5 KCNA5 CDKN1B CDKN1B ACVRL1 ACVRL1 SIRT4 SIRT4 RGCC RGCC MMP14 MMP14 EGLN3 EGLN3 HIF1A HIF1A TGFB3 TGFB3 NGB NGB CHRNA7 CHRNA7 PML PML STUB1 STUB1 CIAO3 CIAO3 HMOX2 HMOX2 ABAT ABAT MT3 MT3 HSD11B2 HSD11B2 SLC2A4 SLC2A4 TP53 TP53 MYOCD MYOCD NOS2 NOS2 SLC6A4 SLC6A4 NF1 NF1 NPEPPS NPEPPS BRIP1 BRIP1 CYGB CYGB RPTOR RPTOR P4HB P4HB GATA6 GATA6 ACAA2 ACAA2 SMAD4 SMAD4 ANGPTL4 ANGPTL4 PIN1 PIN1 WDR83 WDR83 WTIP WTIP SIRT2 SIRT2 TGFB1 TGFB1 NOP53 NOP53 PRKCE PRKCE EPAS1 EPAS1 HK2 HK2 FABP1 FABP1 IL1A IL1A NPPC NPPC ANGPT4 ANGPT4 BMP2 BMP2 TM9SF4 TM9SF4 E2F1 E2F1 BMP7 BMP7 BACH1 BACH1 CBS CBS HMOX1 HMOX1 EP300 EP300 PPARA PPARA ITPR2 ITPR2 ITPR1 ITPR1 CAV3 CAV3 LIMD1 LIMD1 RHOA RHOA ADIPOQ ADIPOQ CD38 CD38 SOD3 SOD3 CCNA2 CCNA2 EDNRA EDNRA VEGFC VEGFC TERT-2 TERT-2 KCNMB1 KCNMB1 STC2 STC2 EDN1 EDN1 TREM2 TREM2 SRF SRF FNDC1 FNDC1 AQP1 AQP1 TBL2 TBL2 GNGT1 GNGT1 EPO EPO CAV1 CAV1 HIPK2 HIPK2 ANGPT2 ANGPT2 STC1 STC1 BNIP3L BNIP3L PTK2B PTK2B PLAT PLAT PENK PENK NDRG1 NDRG1 AQP3 AQP3 CA9 CA9 SLC2A8 SLC2A8 ENG ENG NOTCH1 NOTCH1 VEGFD VEGFD PDK3 PDK3 SUV39H1 SUV39H1 IRAK1-2 IRAK1-2 CPEB2 CPEB2 REST REST ADAM15 ADAM15 DPP4 DPP4 UBQLN1 UBQLN1 APAF1 APAF1 CASR CASR EGLN2 EGLN2 PPARD PPARD LONP1 LONP1 ARNT ARNT BECN1 BECN1 TFRC TFRC CYBB CYBB CLDN3 CLDN3 VEGFB VEGFB TWIST1 TWIST1 PAM PAM PRKAA1 PRKAA1 ENDOG ENDOG AGER AGER UCN3 UCN3 PSEN2 PSEN2 MDM4 MDM4 MST1 MST1 ADAM17 ADAM17 AJUBA AJUBA PLEKHN1 PLEKHN1 SFRP1 SFRP1 VASN VASN ATM ATM RTN4 RTN4 ALKBH5 ALKBH5 PKLR PKLR KCNK2 KCNK2 DNMT3A DNMT3A CYP1A1 CYP1A1 PGF PGF ADO ADO KCNMA1 KCNMA1 ZFP36L1 ZFP36L1 P2RX3 P2RX3 TERT TERT EGLN1 EGLN1 ENSPTRP00000062488 ENSPTRP00000062488 ENSPTRP00000063291 ENSPTRP00000063291 CK820_G0054728 CK820_G0054728 CARD16 CARD16 ATF2 ATF2 SLC8A1 SLC8A1 ATP7A ATP7A RYR2 RYR2 NFE2L2 NFE2L2 ADAM8 ADAM8 PDK1 PDK1 ALAD ALAD LOXL2 LOXL2 TGFBR3 TGFBR3 THBS1 THBS1 SUV39H2 SUV39H2 ANG ANG SLC9A1 SLC9A1 ENSPTRP00000067778 ENSPTRP00000067778 CXCL12 CXCL12 LOC457015 LOC457015 LOC453669 LOC453669 KCND2 KCND2 IRAK1 IRAK1 HILPDA HILPDA NOP53-2 NOP53-2 CBFA2T3 CBFA2T3 MLST8 MLST8 ENSPTRP00000070600 ENSPTRP00000070600 SLC29A1 SLC29A1 SLC11A2 SLC11A2 FAM167A FAM167A MGARP MGARP FMN2 FMN2 ARNT2 ARNT2 NOL3 NOL3 ADA ADA SCAP SCAP SCN2A SCN2A ENSPTRP00000074570 ENSPTRP00000074570 CXCR4 CXCR4 MPL MPL CREBBP CREBBP ERO1A ERO1A TGFBR2 TGFBR2 ENSPTRP00000075315 ENSPTRP00000075315 VHL VHL SCFD1 SCFD1 MYC MYC HP1BP3 HP1BP3 BBC3 BBC3 CK820_G0040447 CK820_G0040447 PPARG PPARG SRC SRC ALAS2 ALAS2 PLOD1 PLOD1 ENSPTRP00000077367 ENSPTRP00000077367 HSP90B1 HSP90B1 JUND JUND SLC2A1 SLC2A1 FOS FOS CFLAR CFLAR CLDN3-2 CLDN3-2 FUNDC1 FUNDC1 RBPJ RBPJ ACTN4 ACTN4 EPO-2 EPO-2 LOC107968591 LOC107968591 ASCL2 ASCL2 NKX3-1 NKX3-1 CPEB1 CPEB1 ENSPTRP00000081300 ENSPTRP00000081300 CITED2 CITED2 CD24 CD24 MECP2 MECP2 ENSPTRP00000082196 ENSPTRP00000082196 NARF NARF ITGA2 ITGA2 P2RX2 P2RX2 BBC3-2 BBC3-2 NPEPPS-2 NPEPPS-2 EGR1 EGR1 KCNK3 KCNK3 PTGIS PTGIS PLOD2 PLOD2 RORA RORA AHCY AHCY ENSPTRP00000087266 ENSPTRP00000087266 ERCC3 ERCC3 LOC455744 LOC455744 HSF1 HSF1 ENSPTRP00000087746 ENSPTRP00000087746 MMP2 MMP2 ENSPTRP00000087855 ENSPTRP00000087855 TXN2 TXN2 CHRNA4 CHRNA4 NR4A2 NR4A2 SDHD SDHD AGTRAP AGTRAP ENSPTRP00000089993 ENSPTRP00000089993 BCL2 BCL2 SLC8A3 SLC8A3 SMAD3 SMAD3 E2F1-2 E2F1-2 PTEN PTEN CK820_G0030361 CK820_G0030361 CAPN2 CAPN2 PHB2 PHB2 CK820_G0042381 CK820_G0042381 CYBA CYBA HIF3A HIF3A NOS1 NOS1 NDNF NDNF SUV39H1-2 SUV39H1-2 ENSPTRP00000092229 ENSPTRP00000092229 RYR1 RYR1 ENSPTRP00000092702 ENSPTRP00000092702 ENSPTRP00000093022 ENSPTRP00000093022 SIRT1-2 SIRT1-2 ADSL ADSL BECN1-2 BECN1-2 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAM162AFamily with sequence similarity 162, member A. (154 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa)
PINK1PTEN induced putative kinase 1. (581 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
PLK3Serine/threonine-protein kinase PLK. (673 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
CLCA1CLCA1 isoform 1. (914 aa)
VCAM1Vascular cell adhesion molecule 1. (650 aa)
CHRNB2CHRNB2 isoform 2. (502 aa)
LMNALMNA isoform 8; Belongs to the intermediate filament family. (664 aa)
USF1Upstream transcription factor 1. (310 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CK820_G0023253FMN2 isoform 2. (1196 aa)
SIRT1SIRT1 isoform 2. (751 aa)
STOX1STOX1 isoform 1. (887 aa)
DDIT4DNA-damage-inducible transcript 4. (232 aa)
PLAUPlasminogen activator, urokinase. (431 aa)
PDLIM1PDZ and LIM domain 1. (329 aa)
HIF1ANHypoxia inducible factor 1, alpha subunit inhibitor. (349 aa)
BNIP3BCL2 interacting protein 3. (259 aa)
THTyrosine hydroxylase. (528 aa)
ADMAdrenomedullin. (185 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
HYOU1Hypoxia up-regulated 1. (999 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
RGCCChromosome 13 open reading frame 15. (137 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
NGBNeuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity). (151 aa)
CHRNA7CHRNA7 isoform 7. (511 aa)
PMLPML isoform 6. (836 aa)
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase. (303 aa)
CIAO3Nuclear prelamin A recognition factor-like; Belongs to the NARF family. (508 aa)
HMOX2Heme oxygenase 2. (370 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (515 aa)
MT3MT3 isoform 5; Belongs to the metallothionein superfamily. Type 1 family. (113 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (405 aa)
SLC2A4SLC2A4 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (466 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MYOCDMYOCD isoform 2. (986 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1196 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
NF1Neurofibromin 1. (2839 aa)
NPEPPSAminopeptidase. (813 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1249 aa)
CYGBCYGB isoform 1; Belongs to the globin family. (190 aa)
RPTORRegulatory associated protein of MTOR, complex 1. (1324 aa)
P4HBProtein disulfide-isomerase. (508 aa)
GATA6GATA binding protein 6. (594 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ANGPTL4Angiopoietin-like 4. (406 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
WDR83WD repeat domain 83. (315 aa)
WTIPWT1 interacting protein. (428 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
HK2HK2 isoform 1. (917 aa)
FABP1Fatty acid binding protein 1. (127 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (271 aa)
NPPCNatriuretic peptide C. (126 aa)
ANGPT4ANGPT4 isoform 1. (503 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
E2F1E2F transcription factor 1. (437 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1. (736 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (551 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
EP300E1A binding protein p300. (2175 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (467 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor, type 2. (2727 aa)
ITPR1ITPR1 isoform 3. (2700 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LIMD1LIM domains containing 1. (676 aa)
RHOARas homolog family member A. (193 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CD38CD38 isoform 1. (300 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (240 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
TERT-2Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (762 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
STC2Stanniocalcin 2. (302 aa)
EDN1EDN1 isoform 1. (212 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
FNDC1FNDC1 isoform 1. (1888 aa)
AQP1Aquaporin-1 isoform X2. (269 aa)
TBL2Transducin (Beta)-like 2. (447 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
ANGPT2ANGPT2 isoform 1. (496 aa)
STC1Stanniocalcin 1. (247 aa)
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like. (219 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (649 aa)
PENKPENK isoform 3. (267 aa)
NDRG1NDRG1 isoform 2. (394 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (453 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa)
ENGENG isoform 1. (658 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PDK3Protein-serine/threonine kinase. (417 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (423 aa)
IRAK1-2Interleukin-1 receptor-associated kinase 1. (712 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1036 aa)
RESTRE1 silencing transcription factor. (1097 aa)
ADAM15ADAM metallopeptidase domain 15. (863 aa)
DPP4Dipeptidyl-peptidase 4; Belongs to the peptidase S9B family. (766 aa)
UBQLN1UBQLN1 isoform 1. (589 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CASRCalcium sensing receptor. (1078 aa)
EGLN2T0107007 isoform 1. (407 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (959 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
BECN1Beclin 1, autophagy related. (450 aa)
TFRCTransferrin receptor (P90, CD71). (760 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TWIST1TWIST1 isoform 2. (163 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENDOGEndonuclease. (297 aa)
AGERAdvanced glycosylation end-product specific receptor. (420 aa)
UCN3UCN3 isoform 1. (161 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (485 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
ADAM17ADAM17 isoform 3. (999 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (538 aa)
PLEKHN1PLEKHN1 isoform 3. (663 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
VASNVASN isoform 1. (673 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
RTN4Reticulon. (1192 aa)
ALKBH5alkB homolog 5, RNA demethylase. (394 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
ADO2-aminoethanethiol (Cysteamine) dioxygenase. (270 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1286 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
TERTTelomerase reverse transcriptase. (360 aa)
EGLN1EGLN1 isoform 1. (426 aa)
ENSPTRP00000062488annotation not available (131 aa)
ENSPTRP00000063291annotation not available (883 aa)
CK820_G0054728MECP2 isoform 14. (493 aa)
CARD16Caspase recruitment domain-containing protein 16 isoform X4. (197 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
RYR2RYR2 isoform 1. (4941 aa)
NFE2L2Nuclear factor (Erythroid-derived 2)-like 2. (605 aa)
ADAM8ADAM metallopeptidase domain 8. (824 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
LOXL2LOXL2 isoform 4. (744 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
THBS1Thrombospondin 1. (1173 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
ANGAngiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (147 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ENSPTRP00000067778annotation not available (85 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
LOC457015LOW QUALITY PROTEIN: endoplasmin-like. (448 aa)
LOC453669Ribosome biogenesis protein NOP53 pseudogene. (453 aa)
KCND2Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family. (630 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (712 aa)
HILPDAHypoxia inducible lipid droplet associated. (63 aa)
NOP53-2NOP53 ribosome biogenesis factor. (469 aa)
CBFA2T3CBFA2/RUNX1 translocation partner 3. (653 aa)
MLST8MLST8 isoform 3. (327 aa)
ENSPTRP00000070600annotation not available (412 aa)
SLC29A1Solute carrier family 29 (Nucleoside transporters), member 1. (523 aa)
SLC11A2SLC11A2 isoform 1. (590 aa)
FAM167AFamily with sequence similarity 167 member A. (243 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
FMN2FMN2 isoform 6. (198 aa)
ARNT2ARNT2 isoform 2. (759 aa)
NOL3Nucleolar protein 3. (219 aa)
ADAAdenosine deaminase. (412 aa)
SCAPSCAP isoform 2. (1279 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
ENSPTRP00000074570annotation not available (172 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (423 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (646 aa)
CREBBPCREB binding protein. (2442 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ENSPTRP00000075315annotation not available (127 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (642 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (454 aa)
HP1BP3Heterochromatin protein 1, binding protein 3. (553 aa)
BBC3BCL2 binding component 3. (270 aa)
CK820_G0040447CAPN2 isoform 2; Belongs to the peptidase C2 family. (708 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
SRCTyrosine-protein kinase. (542 aa)
ALAS25-aminolevulinate synthase. (587 aa)
PLOD1Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1. (737 aa)
ENSPTRP00000077367annotation not available (390 aa)
HSP90B1Heat shock protein 90 beta family member 1. (814 aa)
JUNDJUND isoform 1. (346 aa)
SLC2A1Solute carrier family 2 (Facilitated glucose transporter), member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
CLDN3-2Claudin 3. (220 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
ACTN4Actinin, alpha 4. (931 aa)
EPO-2Erythropoietin. (193 aa)
LOC107968591CD24 isoform 1. (80 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
NKX3-1NKX3-1 isoform 1. (234 aa)
CPEB1CPEB1 isoform 5. (626 aa)
ENSPTRP00000081300annotation not available (154 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
CD24CD24 isoform 8. (129 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
ENSPTRP00000082196annotation not available (376 aa)
NARFNARF isoform 2; Belongs to the NARF family. (484 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (497 aa)
BBC3-2BCL2 binding component 3. (270 aa)
NPEPPS-2Puromycin-sensitive aminopeptidase isoform X1. (170 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
KCNK3Potassium channel subfamily K member. (394 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
PLOD2Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2. (758 aa)
RORARAR-related orphan receptor A. (555 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (444 aa)
ENSPTRP00000087266Phosphoglycerate kinase 1. (394 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
LOC455744LOW QUALITY PROTEIN: phosphoglycerate kinase 1-like. (408 aa)
HSF1Heat shock transcription factor 1. (529 aa)
ENSPTRP00000087746annotation not available (429 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ENSPTRP00000087855annotation not available (364 aa)
TXN2Thioredoxin, mitochondrial. (201 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. (640 aa)
NR4A2Nuclear receptor subfamily 4, group A, member 2. (598 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
AGTRAPAngiotensin II receptor-associated protein. (168 aa)
ENSPTRP00000089993annotation not available (58 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
E2F1-2E2F transcription factor 1. (437 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CK820_G0030361RYR1 isoform 5. (4901 aa)
CAPN2Calpain 2, (M/II) large subunit; Belongs to the peptidase C2 family. (703 aa)
PHB2Prohibitin. (299 aa)
CK820_G0042381FLT3LG isoform 12. (98 aa)
CYBACytochrome b-245 alpha chain. (210 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (669 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
NDNFNDNF isoform 1. (568 aa)
SUV39H1-2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
ENSPTRP00000092229annotation not available (407 aa)
RYR1RYR1 isoform 3. (5037 aa)
ENSPTRP00000092702annotation not available (482 aa)
ENSPTRP00000093022annotation not available (563 aa)
SIRT1-2Sirtuin 1. (751 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa)
BECN1-2BECN1 isoform 3. (371 aa)
BADBcl2-associated agonist of cell death. (168 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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