STRINGSTRING
TBX3 TBX3 PRDM14 PRDM14 TBX10 TBX10 PTCH1 PTCH1 APC2 APC2 FOXA2 FOXA2 PAX2 PAX2 ENSPTRP00000092254 ENSPTRP00000092254 EYA2 EYA2 CTNNB1 CTNNB1 GLI2 GLI2 TBX22 TBX22 NOTCH1 NOTCH1 DMRT3 DMRT3 MYT1L MYT1L ATOH1 ATOH1 EHMT2 EHMT2 SUFU SUFU PTCH2 PTCH2 ITGB1 ITGB1 OLIG2 OLIG2 TBX5 TBX5 ETV2 ETV2 CDON CDON FEV FEV POU4F1 POU4F1 DMRTA2 DMRTA2 NRP1 NRP1 NODAL NODAL TENM4 TENM4 TEAD4 TEAD4 HOXC10 HOXC10 DBX1 DBX1 SMO-2 SMO-2 PSEN1 PSEN1 GSC GSC MGA MGA ISL2 ISL2 TBX6 TBX6 TBX21 TBX21 TBX2 TBX2 TBX4 TBX4 SOX9 SOX9 FKBP8 FKBP8 SIX2 SIX2 HOXD10 HOXD10 IHH IHH NKX2-2 NKX2-2 SOX18 SOX18 TBX1 TBX1 EOMES EOMES GSX2 GSX2 SFRP2 SFRP2 ISL1 ISL1 APC APC TLX3 TLX3 TBX18 TBX18 OLIG3 OLIG3 TBXT TBXT DLL1 DLL1 HOXA11 HOXA11 TBX20 TBX20 GLI3 GLI3 MYL10 MYL10 SMO SMO SOX17 SOX17 EYA1 EYA1 PAX6 PAX6 TBX15 TBX15 TBX19 TBX19 HOXA13 HOXA13 LHX3 LHX3 FOXA1 FOXA1 SOX1 SOX1 HOXA13-2 HOXA13-2 MNX1 MNX1 SOX2 SOX2 TBR1 TBR1 DHH DHH SHH SHH MYL10-2 MYL10-2 ENSPTRP00000077262 ENSPTRP00000077262 ASCL1 ASCL1 ENSPTRP00000079007 ENSPTRP00000079007 RBPJ RBPJ MYL2 MYL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX3T-box transcription factor 3. (743 aa)
PRDM14PR/SET domain 14. (571 aa)
TBX10T-box transcription factor 10. (387 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
APC2APC2 isoform 1. (2301 aa)
FOXA2FOXA2 isoform 1. (464 aa)
PAX2PAX2 isoform 1. (417 aa)
ENSPTRP00000092254annotation not available (222 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
GLI2GLI family zinc finger 2. (1587 aa)
TBX22T-box transcription factor 22. (520 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
MYT1LMyelin transcription factor 1 like. (1185 aa)
ATOH1Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity). (356 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
PTCH2PTCH2 isoform 3. (1203 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
OLIG2OLIG2 isoform 1. (323 aa)
TBX5T-box transcription factor 5. (518 aa)
ETV2ETV2 isoform 5. (370 aa)
CDONCell adhesion associated, oncogene regulated. (1286 aa)
FEVFEV transcription factor, ETS family member. (238 aa)
POU4F1POU domain protein. (350 aa)
DMRTA2DMRT like family A2. (539 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NODALNODAL isoform 2. (347 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
DBX1Developing brain homeobox 1. (345 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
GSCHomeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (257 aa)
MGAMAX dimerization protein MGA. (3068 aa)
ISL2ISL LIM homeobox 2. (359 aa)
TBX6T-box transcription factor 6. (443 aa)
TBX21T-box transcription factor 21. (535 aa)
TBX2T-box transcription factor 2. (712 aa)
TBX4TBX4 isoform 1. (545 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
SIX2SIX homeobox 2. (291 aa)
HOXD10Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (410 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
SOX18SOX18 isoform 1. (384 aa)
TBX1TBX1 isoform 1. (478 aa)
EOMESEOMES isoform 2. (704 aa)
GSX2GSX2 isoform 2. (304 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
ISL1ISL LIM homeobox 1. (349 aa)
APCAdenomatous polyposis coli protein isoform X10. (2844 aa)
TLX3TLX3 isoform 1. (291 aa)
TBX18T-box transcription factor 18. (607 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
TBXTT-box transcription factor T. (435 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
HOXA11HOXA11 isoform 2. (313 aa)
TBX20T-box transcription factor 20. (447 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
MYL10ADCY7 isoform 13. (226 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
SOX17SOX17 isoform 1. (416 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
PAX6PAX6 isoform 13. (436 aa)
TBX15T-box transcription factor 15. (602 aa)
TBX19T-box transcription factor 19. (448 aa)
HOXA13Homeobox A13. (388 aa)
LHX3LHX3 isoform 2. (402 aa)
FOXA1FOXA1 isoform 1. (471 aa)
SOX1SOX1 isoform 1. (391 aa)
HOXA13-2HOXA13 isoform 1. (388 aa)
MNX1Motor neuron and pancreas homeobox 1. (398 aa)
SOX2SRY-box transcription factor 2. (319 aa)
TBR1T-box brain transcription factor 1. (682 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
MYL10-2MYL10 isoform 1. (226 aa)
ENSPTRP00000077262annotation not available (314 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
ENSPTRP00000079007annotation not available (323 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
MYL2Myosin, light chain 2, regulatory, cardiac, slow. (166 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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