STRINGSTRING
PCSK9 PCSK9 HMGCS2 HMGCS2 HLX HLX UPF2 UPF2 NODAL NODAL MKI67 MKI67 E2F8 E2F8 UCP2 UCP2 ACAT1 ACAT1 WNT1 WNT1 PDX1 PDX1 CPB2 CPB2 PCK2 PCK2 NKX2-8 NKX2-8 SRSF5 SRSF5 SERPINA10 SERPINA10 ALDH1A2 ALDH1A2 RPGRIP1L RPGRIP1L SLC7A5 SLC7A5 NF1 NF1 MED1 MED1 SOX9 SOX9 CCDC40 CCDC40 TYMS TYMS GATA6 GATA6 PRKCSH PRKCSH HAMP HAMP TGFB1 TGFB1 FRZB FRZB IHH IHH CUL3 CUL3 PCNA PCNA AURKA AURKA PCK1 PCK1 UPB1 UPB1 HMOX1 HMOX1 MPST MPST ACO2 ACO2 CLDN1 CLDN1 HNRNPD HNRNPD PKD2 PKD2 SRD5A1 SRD5A1 PTCD2 PTCD2 SEC63 SEC63 C6H6orf58 C6H6orf58 ARG1 ARG1 FGL1 FGL1 RB1CC1 RB1CC1 PHF2 PHF2 ASS1 ASS1 NOTCH1 NOTCH1 OTC OTC RGN RGN ELK1 ELK1 SMARCB1 SMARCB1 RHBDD3 RHBDD3 DNAAF1 DNAAF1 MAN2A1 MAN2A1 ANXA1 ANXA1 CCDC39 CCDC39 PROX1 PROX1 ACADM ACADM RARA RARA CSNK2A2 CSNK2A2 RELA RELA CYP1A1 CYP1A1 ENSPTRP00000062039 ENSPTRP00000062039 ENSPTRP00000062077 ENSPTRP00000062077 IGF2R IGF2R WNT4 WNT4 PRMT5 PRMT5 ATF2 ATF2 TAF10 TAF10 HES1 HES1 ATP7A ATP7A CK820_G0056924 CK820_G0056924 ENSPTRP00000065149 ENSPTRP00000065149 XBP1 XBP1 TGFBR3 TGFBR3 ZIC3 ZIC3 ENSPTRP00000066621 ENSPTRP00000066621 JARID2 JARID2 IL6 IL6 ENSPTRP00000069128 ENSPTRP00000069128 GFER GFER PTPN3 PTPN3 ARF6 ARF6 LOC461877 LOC461877 LOC100609621 LOC100609621 ENSPTRP00000071015 ENSPTRP00000071015 CPT1A CPT1A HGF HGF ENSPTRP00000073414 ENSPTRP00000073414 ONECUT1 ONECUT1 ADA ADA RGN-2 RGN-2 NOTCH2 NOTCH2 CADM1 CADM1 ENSPTRP00000076749 ENSPTRP00000076749 EZH2 EZH2 GLI1 GLI1 LOC741786 LOC741786 LOC107971060 LOC107971060 TGFA TGFA IL6-2 IL6-2 ZMPSTE24 ZMPSTE24 ONECUT2 ONECUT2 CIT CIT LSR LSR CITED2 CITED2 CDK5RAP3 CDK5RAP3 HNF1B HNF1B ITGA2 ITGA2 CEBPG CEBPG COBL COBL CDKN2B CDKN2B MET MET ENSPTRP00000083313 ENSPTRP00000083313 CK820_G0054628 CK820_G0054628 ENSPTRP00000083809 ENSPTRP00000083809 PNPT1 PNPT1 HNF1A HNF1A PIK3CA PIK3CA TBX3 TBX3 SP3 SP3 FPGS FPGS CEBPB CEBPB CCND1 CCND1 CPS1 CPS1 HNF4A HNF4A PTCH1 PTCH1 ENSPTRP00000087913 ENSPTRP00000087913 ARID5B ARID5B E2F7 E2F7 BAAT BAAT EZH2-2 EZH2-2 SMAD3 SMAD3 RPS6KA1 RPS6KA1 ENSPTRP00000092743 ENSPTRP00000092743
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
HLXH2.0-like homeobox. (493 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1272 aa)
NODALNODAL isoform 2. (347 aa)
MKI67MKI67 isoform 1. (3257 aa)
E2F8E2F transcription factor 8. (867 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PDX1Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa)
CPB2Carboxypeptidase B2. (423 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
NKX2-8NKX2-8 isoform 1. (239 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
SERPINA10SERPINA10 isoform 2; Belongs to the serpin family. (484 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
RPGRIP1LRPGRIP1L isoform 4. (1269 aa)
SLC7A5SLC7A5 isoform 2. (507 aa)
NF1Neurofibromin 1. (2839 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
CCDC40CCDC40 isoform 3. (1142 aa)
TYMSThymidylate synthetase. (313 aa)
GATA6GATA binding protein 6. (594 aa)
PRKCSHProtein kinase C substrate 80K-H. (535 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FRZBFrizzled-related protein. (325 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
CUL3CUL3 isoform 2; Belongs to the cullin family. (768 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
UPB1Beta-ureidopropionase 1. (384 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
MPSTSulfurtransferase. (317 aa)
ACO2ACO2 isoform 2. (800 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
HNRNPDHNRNPD isoform 1. (356 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
SEC63SEC63 homolog, protein translocation regulator. (760 aa)
C6H6orf58Chromosome 6 C6orf58 homolog. (330 aa)
ARG1Arginase. (322 aa)
FGL1Fibrinogen like 1. (312 aa)
RB1CC1RB1-inducible coiled-coil 1. (1594 aa)
PHF2PHF2 isoform 1. (1080 aa)
ASS1Argininosuccinate synthetase 1. (412 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa)
RGNRegucalcin (Senescence marker protein-30). (299 aa)
ELK1ELK1, member of ETS oncogene family. (428 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (394 aa)
RHBDD3Rhomboid domain containing 3. (386 aa)
DNAAF1Dynein assembly factor 1, axonemal. (725 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)
CCDC39Coiled-coil domain containing 39. (941 aa)
PROX1Prospero homeobox 1. (737 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (412 aa)
RARARARA isoform 4. (624 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
ENSPTRP00000062039annotation not available (397 aa)
ENSPTRP00000062077annotation not available (236 aa)
IGF2RIGF2R isoform 2. (2491 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
ENSPTRP00000065149annotation not available (523 aa)
XBP1XBP1 isoform 4. (381 aa)
TGFBR3Transforming growth factor, beta receptor III. (861 aa)
ZIC3Zic family member 3. (466 aa)
ENSPTRP00000066621annotation not available (709 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
IL6Interleukin 6 (Interferon, beta 2). (234 aa)
ENSPTRP00000069128annotation not available (157 aa)
GFERSulfhydryl oxidase. (204 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1027 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LOC461877Argininosuccinate synthase pseudogene. (389 aa)
LOC100609621Argininosuccinate synthase pseudogene. (245 aa)
ENSPTRP00000071015annotation not available (408 aa)
CPT1ACarnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa)
ENSPTRP00000073414annotation not available (393 aa)
ONECUT1One cut domain family member. (465 aa)
ADAAdenosine deaminase. (412 aa)
RGN-2Regucalcin. (299 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
CADM1Cell adhesion molecule 1. (470 aa)
ENSPTRP00000076749annotation not available (243 aa)
EZH2Enhancer of zeste homolog 2. (754 aa)
GLI1GLI family zinc finger 1. (1106 aa)
LOC741786CDK5RAP3 isoform 6. (501 aa)
LOC107971060SRD5A1 isoform 2. (141 aa)
TGFATGFA isoform 6. (193 aa)
IL6-2Interleukin 6. (234 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
ONECUT2One cut domain family member. (504 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2078 aa)
LSRLipolysis stimulated lipoprotein receptor. (650 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (534 aa)
HNF1BHNF1 homeobox B. (557 aa)
ITGA2Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa)
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma. (150 aa)
COBLCordon-bleu WH2 repeat protein. (1333 aa)
CDKN2BCyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
ENSPTRP00000083313annotation not available (104 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
ENSPTRP00000083809annotation not available (152 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (784 aa)
HNF1AHNF1 homeobox A. (662 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
TBX3T-box transcription factor 3. (743 aa)
SP3Sp3 transcription factor. (781 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (587 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
CCND1CCND1 isoform 1; Belongs to the cyclin family. (295 aa)
CPS1Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PTCH1PTCH1 isoform 8. (1428 aa)
ENSPTRP00000087913annotation not available (354 aa)
ARID5BARID5B isoform 1. (1187 aa)
E2F7E2F transcription factor 7. (911 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (418 aa)
EZH2-2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
SMAD3Mothers against decapentaplegic homolog. (442 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ENSPTRP00000092743annotation not available (379 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (18%) [HD]