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PCSK9 | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (813 aa) | ||||
HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa) | ||||
HLX | H2.0-like homeobox. (493 aa) | ||||
UPF2 | UPF2 regulator of nonsense mediated mRNA decay. (1272 aa) | ||||
NODAL | NODAL isoform 2. (347 aa) | ||||
MKI67 | MKI67 isoform 1. (3257 aa) | ||||
E2F8 | E2F transcription factor 8. (867 aa) | ||||
UCP2 | Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa) | ||||
ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa) | ||||
WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) | ||||
PDX1 | Pancreas/duodenum homeobox protein 1; Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (283 aa) | ||||
CPB2 | Carboxypeptidase B2. (423 aa) | ||||
PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa) | ||||
NKX2-8 | NKX2-8 isoform 1. (239 aa) | ||||
SRSF5 | Serine and arginine rich splicing factor 5. (272 aa) | ||||
SERPINA10 | SERPINA10 isoform 2; Belongs to the serpin family. (484 aa) | ||||
ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) | ||||
RPGRIP1L | RPGRIP1L isoform 4. (1269 aa) | ||||
SLC7A5 | SLC7A5 isoform 2. (507 aa) | ||||
NF1 | Neurofibromin 1. (2839 aa) | ||||
MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa) | ||||
SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa) | ||||
CCDC40 | CCDC40 isoform 3. (1142 aa) | ||||
TYMS | Thymidylate synthetase. (313 aa) | ||||
GATA6 | GATA binding protein 6. (594 aa) | ||||
PRKCSH | Protein kinase C substrate 80K-H. (535 aa) | ||||
HAMP | Hepcidin antimicrobial peptide. (84 aa) | ||||
TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) | ||||
FRZB | Frizzled-related protein. (325 aa) | ||||
IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) | ||||
CUL3 | CUL3 isoform 2; Belongs to the cullin family. (768 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
AURKA | Serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (403 aa) | ||||
PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) | ||||
UPB1 | Beta-ureidopropionase 1. (384 aa) | ||||
HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa) | ||||
MPST | Sulfurtransferase. (317 aa) | ||||
ACO2 | ACO2 isoform 2. (800 aa) | ||||
CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) | ||||
HNRNPD | HNRNPD isoform 1. (356 aa) | ||||
PKD2 | Polycystin 2, transient receptor potential cation channel. (968 aa) | ||||
SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (259 aa) | ||||
PTCD2 | Pentatricopeptide repeat domain 2. (388 aa) | ||||
SEC63 | SEC63 homolog, protein translocation regulator. (760 aa) | ||||
C6H6orf58 | Chromosome 6 C6orf58 homolog. (330 aa) | ||||
ARG1 | Arginase. (322 aa) | ||||
FGL1 | Fibrinogen like 1. (312 aa) | ||||
RB1CC1 | RB1-inducible coiled-coil 1. (1594 aa) | ||||
PHF2 | PHF2 isoform 1. (1080 aa) | ||||
ASS1 | Argininosuccinate synthetase 1. (412 aa) | ||||
NOTCH1 | NOTCH1 isoform 1. (2555 aa) | ||||
OTC | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (354 aa) | ||||
RGN | Regucalcin (Senescence marker protein-30). (299 aa) | ||||
ELK1 | ELK1, member of ETS oncogene family. (428 aa) | ||||
SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (394 aa) | ||||
RHBDD3 | Rhomboid domain containing 3. (386 aa) | ||||
DNAAF1 | Dynein assembly factor 1, axonemal. (725 aa) | ||||
MAN2A1 | Alpha-mannosidase. (1144 aa) | ||||
ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa) | ||||
CCDC39 | Coiled-coil domain containing 39. (941 aa) | ||||
PROX1 | Prospero homeobox 1. (737 aa) | ||||
ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (412 aa) | ||||
RARA | RARA isoform 4. (624 aa) | ||||
CSNK2A2 | Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa) | ||||
RELA | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa) | ||||
CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa) | ||||
ENSPTRP00000062039 | annotation not available (397 aa) | ||||
ENSPTRP00000062077 | annotation not available (236 aa) | ||||
IGF2R | IGF2R isoform 2. (2491 aa) | ||||
WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) | ||||
PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa) | ||||
ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) | ||||
TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) | ||||
HES1 | Hes family bHLH transcription factor 1. (280 aa) | ||||
ATP7A | ATPase, Cu++ transporting, alpha polypeptide. (1500 aa) | ||||
CK820_G0056924 | NPIPA2 isoform 1. (277 aa) | ||||
ENSPTRP00000065149 | annotation not available (523 aa) | ||||
XBP1 | XBP1 isoform 4. (381 aa) | ||||
TGFBR3 | Transforming growth factor, beta receptor III. (861 aa) | ||||
ZIC3 | Zic family member 3. (466 aa) | ||||
ENSPTRP00000066621 | annotation not available (709 aa) | ||||
JARID2 | Jumonji and AT-rich interaction domain containing 2. (1246 aa) | ||||
IL6 | Interleukin 6 (Interferon, beta 2). (234 aa) | ||||
ENSPTRP00000069128 | annotation not available (157 aa) | ||||
GFER | Sulfhydryl oxidase. (204 aa) | ||||
PTPN3 | Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1027 aa) | ||||
ARF6 | ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa) | ||||
LOC461877 | Argininosuccinate synthase pseudogene. (389 aa) | ||||
LOC100609621 | Argininosuccinate synthase pseudogene. (245 aa) | ||||
ENSPTRP00000071015 | annotation not available (408 aa) | ||||
CPT1A | Carnitine palmitoyltransferase 1A (Liver); Belongs to the carnitine/choline acetyltransferase family. (773 aa) | ||||
HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (812 aa) | ||||
ENSPTRP00000073414 | annotation not available (393 aa) | ||||
ONECUT1 | One cut domain family member. (465 aa) | ||||
ADA | Adenosine deaminase. (412 aa) | ||||
RGN-2 | Regucalcin. (299 aa) | ||||
NOTCH2 | NOTCH2 isoform 1. (2612 aa) | ||||
CADM1 | Cell adhesion molecule 1. (470 aa) | ||||
ENSPTRP00000076749 | annotation not available (243 aa) | ||||
EZH2 | Enhancer of zeste homolog 2. (754 aa) | ||||
GLI1 | GLI family zinc finger 1. (1106 aa) | ||||
LOC741786 | CDK5RAP3 isoform 6. (501 aa) | ||||
LOC107971060 | SRD5A1 isoform 2. (141 aa) | ||||
TGFA | TGFA isoform 6. (193 aa) | ||||
IL6-2 | Interleukin 6. (234 aa) | ||||
ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa) | ||||
ONECUT2 | One cut domain family member. (504 aa) | ||||
CIT | Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2078 aa) | ||||
LSR | Lipolysis stimulated lipoprotein receptor. (650 aa) | ||||
CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa) | ||||
CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (534 aa) | ||||
HNF1B | HNF1 homeobox B. (557 aa) | ||||
ITGA2 | Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Belongs to the integrin alpha chain family. (1183 aa) | ||||
CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma. (150 aa) | ||||
COBL | Cordon-bleu WH2 repeat protein. (1333 aa) | ||||
CDKN2B | Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4). (138 aa) | ||||
MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa) | ||||
ENSPTRP00000083313 | annotation not available (104 aa) | ||||
CK820_G0054628 | PKD1 isoform 4. (3384 aa) | ||||
ENSPTRP00000083809 | annotation not available (152 aa) | ||||
PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (784 aa) | ||||
HNF1A | HNF1 homeobox A. (662 aa) | ||||
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa) | ||||
TBX3 | T-box transcription factor 3. (743 aa) | ||||
SP3 | Sp3 transcription factor. (781 aa) | ||||
FPGS | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (587 aa) | ||||
CEBPB | CCAAT/enhancer-binding protein. (347 aa) | ||||
CCND1 | CCND1 isoform 1; Belongs to the cyclin family. (295 aa) | ||||
CPS1 | Carbamoyl-phosphate synthase 1, mitochondrial. (1507 aa) | ||||
HNF4A | Hepatocyte nuclear factor 4 alpha. (474 aa) | ||||
PTCH1 | PTCH1 isoform 8. (1428 aa) | ||||
ENSPTRP00000087913 | annotation not available (354 aa) | ||||
ARID5B | ARID5B isoform 1. (1187 aa) | ||||
E2F7 | E2F transcription factor 7. (911 aa) | ||||
BAAT | Bile acid-CoA:amino acid N-acyltransferase. (418 aa) | ||||
EZH2-2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa) | ||||
SMAD3 | Mothers against decapentaplegic homolog. (442 aa) | ||||
RPS6KA1 | Ribosomal protein S6 kinase. (744 aa) | ||||
ENSPTRP00000092743 | annotation not available (379 aa) |