STRINGSTRING
PKD2 PKD2 RTL1 RTL1 PPARG PPARG NOTCH2 NOTCH2 DNAJB6 DNAJB6 ENSPTRP00000074403 ENSPTRP00000074403 DEDD DEDD TFEB TFEB ADA ADA MAP3K4 MAP3K4 LEP LEP CDX2 CDX2 EGFR EGFR HEY1 HEY1 ETV2 ETV2 ZNF568 ZNF568 ENSPTRP00000066927 ENSPTRP00000066927 ENSPTRP00000066621 ENSPTRP00000066621 SNAI1 SNAI1 MDFI-2 MDFI-2 NSDHL-2 NSDHL-2 ENSPTRP00000065085 ENSPTRP00000065085 CK820_G0056924 CK820_G0056924 TRIM28 TRIM28 HES1 HES1 WNT7B WNT7B LHX3 LHX3 STK4 STK4 ENSPTRP00000062821 ENSPTRP00000062821 EGLN1 EGLN1 APELA APELA ZFP36L1 ZFP36L1 RTL5 RTL5 RPS6 RPS6 TAF10 TAF10 CCNF CCNF HECTD1 HECTD1 GATA2 GATA2 DAZAP1 DAZAP1 EPOR EPOR JUNB JUNB BMPR2 BMPR2 PEG10 PEG10 GJB5 GJB5 ARNT ARNT PPARD PPARD KRT19 KRT19 NSDHL NSDHL PLAC1 PLAC1 CDX4 CDX4 CITED1 CITED1 NDP NDP GRHL2 GRHL2 TTPA TTPA STC1 STC1 CTSB CTSB WNT2 WNT2 PLG PLG RSPO3 RSPO3 HEY2 HEY2 PRDM1 PRDM1 BMP5 BMP5 GCM1 GCM1 HSP90AB1 HSP90AB1 CUL7 CUL7 MDFI MDFI MAPK14 MAPK14 STC2 STC2 ADAM19 ADAM19 HAND1 HAND1 PCDH12 PCDH12 CSF2 CSF2 STOX2 STOX2 PLK4 PLK4 GHRL GHRL GHSR GHSR SETD2 SETD2 EOMES EOMES CCDC134 CCDC134 PDGFB PDGFB RTCB RTCB LIF LIF MAPK1 MAPK1 BMP7 BMP7 FZD5 FZD5 CASP8 CASP8 HS6ST1 HS6ST1 EPAS1 EPAS1 TCF23 TCF23 NCOA1 NCOA1 BSG BSG GRB2 GRB2 BPTF BPTF DLX3 DLX3 MED1 MED1 GGNBP2 GGNBP2 SOX15 SOX15 HSD17B2 HSD17B2 SPINT1 SPINT1 ALKBH1 ALKBH1 HIF1A HIF1A FBXW8 FBXW8 CYP27B1 CYP27B1 CDKN1B CDKN1B BIRC2 BIRC2 FOSL1 FOSL1 MEN1 MEN1 E2F8 E2F8 ADM ADM HTRA1 HTRA1 FGFR2 FGFR2 PRDX3 PRDX3 NODAL NODAL VASH2 VASH2 IL10 IL10 ETNK2 ETNK2 PTGS2 PTGS2 LHX4 LHX4 ASH1L ASH1L RBM15 RBM15 CCN1 CCN1 BPTF-2 BPTF-2 SPP1 SPP1 SOCS3 SOCS3 OVOL2 OVOL2 FBN2 FBN2 TTPAL TTPAL TPPP3 TPPP3 ST14 ST14 MME MME ENSPTRP00000089747 ENSPTRP00000089747 E2F7 E2F7 CK820_G0007197 CK820_G0007197 ZFAT ZFAT VASH1 VASH1 BIRC6 BIRC6 CEBPB CEBPB SP3 SP3 ITGB8-2 ITGB8-2 HNF1A HNF1A PLCD3 PLCD3 VDR VDR TMED2 TMED2 PTK2 PTK2 CK820_G0054628 CK820_G0054628 AKT1 AKT1 ITGB8 ITGB8 CITED2 CITED2 ENSPTRP00000081143 ENSPTRP00000081143 TEX19 TEX19 STK3 STK3 ASCL2 ASCL2 PTN PTN LEF1 LEF1 ENSPTRP00000079686 ENSPTRP00000079686 RBPJ RBPJ ENSPTRP00000079023 ENSPTRP00000079023 IGF2 IGF2 NR2F2 NR2F2 CK820_G0021556 CK820_G0021556
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
RTL1RTL1 isoform 1. (1359 aa)
PPARGPeroxisome proliferator-activated receptor gamma isoform X2. (505 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
DNAJB6DnaJ heat shock protein family (Hsp40) member B6. (334 aa)
ENSPTRP00000074403annotation not available (115 aa)
DEDDDeath effector domain containing. (348 aa)
TFEBTranscription factor EB. (490 aa)
ADAAdenosine deaminase. (412 aa)
MAP3K4MAP3K4 isoform 5. (1601 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
CDX2Caudal type homeobox 2. (313 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
ETV2ETV2 isoform 5. (370 aa)
ZNF568ZNF568 isoform 4. (675 aa)
ENSPTRP00000066927annotation not available (133 aa)
ENSPTRP00000066621annotation not available (709 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
MDFI-2MyoD family inhibitor. (246 aa)
NSDHL-2NAD(P) dependent steroid dehydrogenase-like. (373 aa)
ENSPTRP00000065085annotation not available (133 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
TRIM28Tripartite motif containing 28. (835 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LHX3LHX3 isoform 2. (402 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
ENSPTRP00000062821annotation not available (220 aa)
EGLN1EGLN1 isoform 1. (426 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
RTL5Retrotransposon Gag like 5. (569 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
CCNFCCNF isoform 1; Belongs to the cyclin family. (786 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
GATA2GATA binding protein 2. (480 aa)
DAZAP1DAZAP1 isoform 7. (431 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
PEG10PEG10 isoform 4. (775 aa)
GJB5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
KRT19KRT19 isoform 1; Belongs to the intermediate filament family. (400 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
PLAC1Placenta enriched 1. (212 aa)
CDX4Caudal type homeobox 4. (284 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
NDPNorrin cystine knot growth factor NDP. (133 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
TTPAAlpha tocopherol transfer protein. (278 aa)
STC1Stanniocalcin 1. (247 aa)
CTSBCTSB isoform 10; Belongs to the peptidase C1 family. (339 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
RSPO3RSPO3 isoform 1. (292 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
PRDM1PR/SET domain 1. (825 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
HSP90AB1HSP90AB1 isoform 1. (688 aa)
CUL7CUL7 isoform 2; Belongs to the cullin family. (1782 aa)
MDFIMyoD family inhibitor. (246 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
STC2Stanniocalcin 2. (302 aa)
ADAM19ADAM metallopeptidase domain 19. (918 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
PCDH12PCDH12 isoform 1. (1184 aa)
CSF2Colony stimulating factor 2. (144 aa)
STOX2STOX2 isoform 1. (926 aa)
PLK4Polo-like kinase 4. (970 aa)
GHRLGHRL isoform 10. (117 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
EOMESEOMES isoform 2. (704 aa)
CCDC134Coiled-coil domain containing 134. (229 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RTCBRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. (505 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
TCF23Transcription factor 23. (214 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
BSGBSG isoform 8. (383 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BPTFBPTF isoform 2. (3043 aa)
DLX3Distal-less homeobox 3. (287 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
GGNBP2Gametogenetin binding protein 2. (697 aa)
SOX15SOX15 isoform 1. (233 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (387 aa)
SPINT1SPINT1 isoform 2. (529 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
FBXW8F-box and WD repeat domain containing 8. (597 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B (P27, Kip1). (198 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
MEN1MEN1 isoform 14. (615 aa)
E2F8E2F transcription factor 8. (867 aa)
ADMAdrenomedullin. (185 aa)
HTRA1HtrA serine peptidase 1. (522 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PRDX3PRDX3 isoform 1. (256 aa)
NODALNODAL isoform 2. (347 aa)
VASH2VASH2 isoform 6. (355 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
ETNK2Ethanolamine kinase 2. (394 aa)
PTGS2Prostaglandin-endoperoxide synthase 2 (Prostaglandin G/H synthase and cyclooxygenase). (604 aa)
LHX4LHX4 isoform 1. (390 aa)
ASH1LASH1 like histone lysine methyltransferase. (2969 aa)
RBM15RNA binding motif protein 15. (977 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
BPTF-2BPTF isoform 1. (2776 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
FBN2FBN2 isoform 1. (2912 aa)
TTPALTocopherol (Alpha) transfer protein-like. (342 aa)
TPPP3Tubulin polymerization-promoting protein family member 3. (176 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
MMEMembrane metallo-endopeptidase. (750 aa)
ENSPTRP00000089747annotation not available (156 aa)
E2F7E2F transcription factor 7. (911 aa)
CK820_G0007197TFEB isoform 4. (550 aa)
ZFATZinc finger and AT hook domain containing. (1243 aa)
VASH1VASH1 isoform 1. (365 aa)
BIRC6BIRC6 isoform 5. (4904 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
SP3Sp3 transcription factor. (781 aa)
ITGB8-2Integrin subunit beta 8. (780 aa)
HNF1AHNF1 homeobox A. (662 aa)
PLCD3Phosphoinositide phospholipase C. (789 aa)
VDRVitamin D (1,25-dihydroxyvitamin D3) receptor. (477 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (780 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ENSPTRP00000081143annotation not available (219 aa)
TEX19Testis expressed 19. (164 aa)
STK3Serine/threonine kinase 3. (519 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
PTNPTN isoform 2. (172 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ENSPTRP00000079686annotation not available (213 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
ENSPTRP00000079023annotation not available (237 aa)
IGF2Insulin like growth factor 2. (236 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (14%) [HD]