STRINGSTRING
ZFAT ZFAT CK820_G0007197 CK820_G0007197 E2F7 E2F7 ENSPTRP00000089747 ENSPTRP00000089747 ST14 ST14 TTPAL TTPAL SOCS3 SOCS3 OVOL2 OVOL2 CCN1 CCN1 IL10 IL10 VASH2 VASH2 NODAL NODAL FGFR2 FGFR2 ADM ADM E2F8 E2F8 BPTF-2 BPTF-2 FBXW8 FBXW8 HIF1A HIF1A SPINT1 SPINT1 SOX15 SOX15 GGNBP2 GGNBP2 MED1 MED1 BPTF BPTF GRB2 GRB2 NCOA1 NCOA1 EPAS1 EPAS1 HS6ST1 HS6ST1 CASP8 CASP8 FZD5 FZD5 BMP7 BMP7 MAPK1 MAPK1 LIF LIF PDGFB PDGFB EOMES EOMES SETD2 SETD2 PKD2 PKD2 PLK4 PLK4 CSF2 CSF2 PCDH12 PCDH12 HAND1 HAND1 MDFI MDFI GCM1 GCM1 BMP5 BMP5 PRDM1 PRDM1 HEY2 HEY2 RSPO3 RSPO3 PLG PLG WNT2 WNT2 TTPA TTPA GRHL2 GRHL2 CITED1 CITED1 CDX4 CDX4 NSDHL NSDHL KRT19 KRT19 ARNT ARNT GJB5 GJB5 PEG10 PEG10 JUNB JUNB GATA2 GATA2 HECTD1 HECTD1 TAF10 TAF10 RTL5 RTL5 ZFP36L1 ZFP36L1 EGLN1 EGLN1 STK4 STK4 WNT7B WNT7B HES1 HES1 TRIM28 TRIM28 CK820_G0056924 CK820_G0056924 NSDHL-2 NSDHL-2 MDFI-2 MDFI-2 SNAI1 SNAI1 ENSPTRP00000066621 ENSPTRP00000066621 ZNF568 ZNF568 HEY1 HEY1 EGFR EGFR CDX2 CDX2 TFEB TFEB DNAJB6 DNAJB6 RTL1 RTL1 CK820_G0021556 CK820_G0021556 NR2F2 NR2F2 IGF2 IGF2 RBPJ RBPJ LEF1 LEF1 ASCL2 ASCL2 STK3 STK3 CITED2 CITED2 AKT1 AKT1 CK820_G0054628 CK820_G0054628 TMED2 TMED2 PLCD3 PLCD3 SP3 SP3 CEBPB CEBPB BIRC6 BIRC6 VASH1 VASH1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFATZinc finger and AT hook domain containing. (1243 aa)
CK820_G0007197TFEB isoform 4. (550 aa)
E2F7E2F transcription factor 7. (911 aa)
ENSPTRP00000089747annotation not available (156 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (862 aa)
TTPALTocopherol (Alpha) transfer protein-like. (342 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
VASH2VASH2 isoform 6. (355 aa)
NODALNODAL isoform 2. (347 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
ADMAdrenomedullin. (185 aa)
E2F8E2F transcription factor 8. (867 aa)
BPTF-2BPTF isoform 1. (2776 aa)
FBXW8F-box and WD repeat domain containing 8. (597 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
SPINT1SPINT1 isoform 2. (529 aa)
SOX15SOX15 isoform 1. (233 aa)
GGNBP2Gametogenetin binding protein 2. (697 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
BPTFBPTF isoform 2. (3043 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
CASP8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (538 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
LIFLeukemia inhibitory factor (Cholinergic differentiation factor). (202 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EOMESEOMES isoform 2. (704 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2564 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (968 aa)
PLK4Polo-like kinase 4. (970 aa)
CSF2Colony stimulating factor 2. (144 aa)
PCDH12PCDH12 isoform 1. (1184 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
MDFIMyoD family inhibitor. (246 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PRDM1PR/SET domain 1. (825 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
RSPO3RSPO3 isoform 1. (292 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (813 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
TTPAAlpha tocopherol transfer protein. (278 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
CDX4Caudal type homeobox 4. (284 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
KRT19KRT19 isoform 1; Belongs to the intermediate filament family. (400 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
GJB5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
PEG10PEG10 isoform 4. (775 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
GATA2GATA binding protein 2. (480 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
RTL5Retrotransposon Gag like 5. (569 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
EGLN1EGLN1 isoform 1. (426 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
TRIM28Tripartite motif containing 28. (835 aa)
CK820_G0056924NPIPA2 isoform 1. (277 aa)
NSDHL-2NAD(P) dependent steroid dehydrogenase-like. (373 aa)
MDFI-2MyoD family inhibitor. (246 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ENSPTRP00000066621annotation not available (709 aa)
ZNF568ZNF568 isoform 4. (675 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CDX2Caudal type homeobox 2. (313 aa)
TFEBTranscription factor EB. (490 aa)
DNAJB6DnaJ heat shock protein family (Hsp40) member B6. (334 aa)
RTL1RTL1 isoform 1. (1359 aa)
CK820_G0021556TMED2 isoform 3. (200 aa)
NR2F2Nuclear receptor subfamily 2, group F, member 2. (414 aa)
IGF2Insulin like growth factor 2. (236 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
STK3Serine/threonine kinase 3. (519 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
CK820_G0054628PKD1 isoform 4. (3384 aa)
TMED2Transmembrane emp24 domain trafficking protein 2. (208 aa)
PLCD3Phosphoinositide phospholipase C. (789 aa)
SP3Sp3 transcription factor. (781 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
BIRC6BIRC6 isoform 5. (4904 aa)
VASH1VASH1 isoform 1. (365 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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