STRINGSTRING
CAV1 CAV1 THAP1 THAP1 FGF10 FGF10 NF1 NF1 ITGB1BP1 ITGB1BP1 FGF7 FGF7 BMP4 BMP4 MMP14 MMP14 ACVRL1 ACVRL1 EPHA2 EPHA2 CD34 CD34 NRARP NRARP BMPR2 BMPR2 NOX5 NOX5 CAV2 CAV2 CALCA CALCA XBP1 XBP1 LOXL2 LOXL2 HMOX1 HMOX1 PIK3CB PIK3CB DLG1 DLG1 VSTM4 VSTM4 TEK TEK PROK2 PROK2 SEMA5A SEMA5A TGFBR1 TGFBR1 SCARB1 SCARB1 ERN1 ERN1 PROK1 PROK1 BMP4-2 BMP4-2 BMPER BMPER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
THAP1THAP domain containing, apoptosis associated protein 1. (213 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NF1Neurofibromin 1. (2839 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
EPHA2EPH receptor A2. (976 aa)
CD34CD34 isoform 1. (328 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
NOX5NADPH oxidase 5. (737 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
CALCACalcitonin related polypeptide alpha. (141 aa)
XBP1XBP1 isoform 4. (381 aa)
LOXL2LOXL2 isoform 4. (744 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (311 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
VSTM4V-set and transmembrane domain containing 4. (320 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
PROK2PROK2 isoform 2. (129 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SCARB1SCARB1 isoform 8; Belongs to the CD36 family. (552 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
PROK1PROK1 isoform 1. (105 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
BMPERBMP binding endothelial regulator. (685 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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