STRINGSTRING
APCDD1 APCDD1 HDAC2 HDAC2 FOXQ1 FOXQ1 SOS1 SOS1 RELA RELA GNAS GNAS LOC104003639 LOC104003639 ENSPTRP00000063255 ENSPTRP00000063255 ATP7A ATP7A TNFRSF19 TNFRSF19 NSDHL-2 NSDHL-2 SNAI1 SNAI1 LOC748850 LOC748850 SMO-2 SMO-2 SOSTDC1 SOSTDC1 EGFR EGFR CD109 CD109 TRPC4AP TRPC4AP SHH SHH HDAC1 HDAC1 ERCC2 ERCC2 RBPJ RBPJ LGR5 LGR5 ZMPSTE24 ZMPSTE24 LDB2 LDB2 LRP4 LRP4 ALX4 ALX4 FGF10 FGF10 SOSTDC1-2 SOSTDC1-2 LAMA5 LAMA5 BCL2 BCL2 LOC739070 LOC739070 PLA2G10 PLA2G10 LGR4 LGR4 INHBA INHBA FOXE1 FOXE1 NSUN2 NSUN2 CTNNB1 CTNNB1 FZD6 FZD6 DSG4 DSG4 GLI2 GLI2 LDB1 LDB1 NSDHL NSDHL EDA EDA NOTCH1 NOTCH1 LHX2 LHX2 ZDHHC21 ZDHHC21 EXT1 EXT1 FZD3 FZD3 NOM1 NOM1 SMO SMO FST FST INTU INTU TP63 TP63 KRTAP21-1 KRTAP21-1 SOX18 SOX18 WNT10A WNT10A IGFBP5 IGFBP5 EDAR EDAR PUM2 PUM2 FUZ FUZ PIAS4 PIAS4 SOX9 SOX9 DLX3 DLX3 NGFR NGFR KRT17 KRT17 KRT28 KRT28 KRT27 KRT27 KRT25 KRT25 NF1 NF1 FOXN1 FOXN1 LOC454470 LOC454470 DNASE1L2 DNASE1L2 FGF7 FGF7 SAV1 SAV1 HOXC13 HOXC13 KRT71 KRT71 KRT84 KRT84 ACVR1B ACVR1B FGFR2 FGFR2 DKK1 DKK1 TGFB2 TGFB2 GORAB GORAB TMEM79 TMEM79
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APCDD1Adenomatosis polyposis coli down-regulated 1. (514 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (581 aa)
FOXQ1FOXQ1 isoform 1. (403 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
RELAV-rel reticuloendotheliosis viral oncogene homolog A (Avian). (551 aa)
GNASGNAS isoform 19. (1042 aa)
LOC104003639Guanine nucleotide-binding protein G(s) subunit alpha. (245 aa)
ENSPTRP00000063255annotation not available (394 aa)
ATP7AATPase, Cu++ transporting, alpha polypeptide. (1500 aa)
TNFRSF19Tumor necrosis factor receptor superfamily, member 19. (417 aa)
NSDHL-2NAD(P) dependent steroid dehydrogenase-like. (373 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
LOC748850HDAC2 isoform 9. (445 aa)
SMO-2Smoothened, frizzled class receptor. (786 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CD109CD109 isoform 3. (1446 aa)
TRPC4APTransient receptor potential cation channel, subfamily C, member 4 associated protein. (797 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (480 aa)
LDB2LIM domain binding 2. (373 aa)
LRP4Low density lipoprotein receptor-related protein 4. (1906 aa)
ALX4ALX homeobox 4. (411 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SOSTDC1-2Sclerostin domain containing 1. (206 aa)
LAMA5Laminin, alpha 5. (2203 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
LOC739070PLA2G10 isoform 1. (165 aa)
PLA2G10Group 10 secretory phospholipase A2-like. (165 aa)
LGR4LGR4 isoform 2. (951 aa)
INHBAInhibin subunit beta A. (426 aa)
FOXE1FOXE1 isoform 1. (371 aa)
NSUN2NOP2/Sun domain family, member 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (767 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
FZD6Frizzled homolog 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1059 aa)
GLI2GLI family zinc finger 2. (1587 aa)
LDB1LIM domain binding 1. (411 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (373 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
LHX2LHX2 isoform 1. (406 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
NOM1Nucleolar MIF4G domain-containing protein 1. (859 aa)
SMOSMO isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
FSTFST isoform 1. (344 aa)
INTUInturned planar cell polarity effector homolog. (911 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
KRTAP21-1KRTAP21-1 isoform 1. (79 aa)
SOX18SOX18 isoform 1. (384 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (272 aa)
EDAREctodysplasin A receptor. (496 aa)
PUM2Pumilio RNA binding family member 2. (1065 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
PIAS4Protein inhibitor of activated STAT protein 4. (510 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
DLX3Distal-less homeobox 3. (287 aa)
NGFRNerve growth factor receptor. (427 aa)
KRT17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (432 aa)
KRT28KRT28 isoform 1; Belongs to the intermediate filament family. (464 aa)
KRT27KRT27 isoform 1; Belongs to the intermediate filament family. (459 aa)
KRT25Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity). (450 aa)
NF1Neurofibromin 1. (2839 aa)
FOXN1FOXN1 isoform 2. (648 aa)
LOC454470Keratin, type I cytoskeletal 17-like isoform X1. (437 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (299 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
HOXC13HOXC13 isoform 1. (330 aa)
KRT71KRT71 isoform 1; Belongs to the intermediate filament family. (523 aa)
KRT84KRT84 isoform 1; Belongs to the intermediate filament family. (600 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
DKK1Dickkopf-like protein 1. (289 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GORABGolgin, RAB6-interacting. (394 aa)
TMEM79Transmembrane protein 79. (394 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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