STRINGSTRING
RHOA RHOA FLRT3 FLRT3 JAG1 JAG1 LRG1 LRG1 PDPN PDPN CCN1 CCN1 CD151 CD151 PLET1 PLET1 ACVRL1 ACVRL1 ITGA5 ITGA5 MPP5 MPP5 DVL2 DVL2 HOXB2 HOXB2 HOXB4 HOXB4 MEGF8 MEGF8 ADAM17 ADAM17 SOS1 SOS1 LIN7C LIN7C NOTCH1 NOTCH1 TBX20 TBX20 BMP5 BMP5 SRF SRF HBEGF HBEGF ARHGAP24 ARHGAP24 PDCD10 PDCD10 DAG1 DAG1 BMP7 BMP7 AJUBA AJUBA TOR1A TOR1A FLNA FLNA PHACTR4 PHACTR4 WNT7A WNT7A DDR1 DDR1 ITGB1 ITGB1 DLL4 DLL4 RHOC RHOC DVL1 DVL1 COL5A1 COL5A1 CEACAM1 CEACAM1 ARHGAP35 ARHGAP35 NOTCH2 NOTCH2 ARHGAP12 ARHGAP12 LAMA1 LAMA1 WNT5A WNT5A CD44 CD44 SOX11 SOX11 MMP12 MMP12 CARMIL2 CARMIL2 MRTFA MRTFA TMEFF2 TMEFF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOARas homolog family member A. (193 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (347 aa)
PDPNPDPN isoform 3. (238 aa)
CCN1CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] (381 aa)
CD151Tetraspanin. (253 aa)
PLET1Placenta expressed transcript 1. (207 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ITGA5ITGA5 isoform 2; Belongs to the integrin alpha chain family. (1098 aa)
MPP5Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
HOXB2HOXB2 isoform 1. (356 aa)
HOXB4HOXB4 isoform 1. (251 aa)
MEGF8Multiple EGF like domains 8. (2842 aa)
ADAM17ADAM17 isoform 3. (999 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
TBX20T-box transcription factor 20. (447 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
HBEGFHeparin-binding EGF-like growth factor. (208 aa)
ARHGAP24Rho GTPase activating protein 24. (748 aa)
PDCD10Programmed cell death 10. (212 aa)
DAG1Dystroglycan 1 (Dystrophin-associated glycoprotein 1). (895 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (538 aa)
TOR1ATorsin. (420 aa)
FLNAFLNA isoform 8. (2711 aa)
PHACTR4Phosphatase and actin regulator. (712 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
DDR1Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes sm [...] (920 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (696 aa)
RHOCRho-related GTP-binding protein RhoC isoform X1. (196 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By simi [...] (743 aa)
COL5A1Collagen type V alpha 1 chain. (1841 aa)
CEACAM1CEACAM1 isoform 3. (518 aa)
ARHGAP35Glucocorticoid receptor DNA binding factor 1. (1519 aa)
NOTCH2NOTCH2 isoform 1. (2612 aa)
ARHGAP12Rho GTPase activating protein 12. (846 aa)
LAMA1Laminin subunit alpha 1. (3104 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CD44CD44 isoform 3. (742 aa)
SOX11Transcription factor SOX. (441 aa)
MMP12MMP12 isoform 1. (470 aa)
CARMIL2CARMIL2 isoform 2. (1436 aa)
MRTFAMyocardin related transcription factor A. (966 aa)
TMEFF2Transmembrane protein with EGF-like and two follistatin-like domains 2. (374 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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