STRINGSTRING
KCNJ3 KCNJ3 KCNE4 KCNE4 OXT OXT ADRA1D ADRA1D SNTA1 SNTA1 KCNE1 KCNE1 CAV3 CAV3 TACR3 TACR3 EDNRA EDNRA HCN1 HCN1 ISL1 ISL1 TMEM161B TMEM161B ADRA1B ADRA1B DSP DSP EDN1 EDN1 BVES BVES HEY2 HEY2 CAV1 CAV1 CK820_G0013720 CK820_G0013720 CACNA1D CACNA1D PLN PLN SREBF1 SREBF1 ENSPTRP00000075494 ENSPTRP00000075494 SPTBN4 SPTBN4 ADA ADA AGTR2 AGTR2 SCN2B SCN2B CACNA2D1 CACNA2D1 GPD1L GPD1L DRD2 DRD2 DMD DMD SCN5A SCN5A EDN3 EDN3 ENSPTRP00000068927 ENSPTRP00000068927 POPDC2 POPDC2 PDE4D PDE4D CACNA1G CACNA1G AKAP9-2 AKAP9-2 RYR2 RYR2 SLC8A1 SLC8A1 ADM2 ADM2 ENSPTRP00000063671 ENSPTRP00000063671 CK820_G0042363 CK820_G0042363 KCNE3 KCNE3 KCND3 KCND3 AVPR1A AVPR1A KCNE5 KCNE5 SPX SPX GCH1 GCH1 KCNE2 KCNE2 SLC1A1 SLC1A1 AKAP9 AKAP9 KCNH2 KCNH2 ANK2 ANK2 CACNB2 CACNB2 SRI SRI SCN10A SCN10A TPM1 TPM1 NOS1AP NOS1AP SRI-2 SRI-2 MYH7 MYH7 ENSPTRP00000082446 ENSPTRP00000082446 CALM1 CALM1 ADRA1A ADRA1A DMD-2 DMD-2 LOC459638 LOC459638 ENSPTRP00000085680 ENSPTRP00000085680 ENSPTRP00000086934 ENSPTRP00000086934 KCNH6 KCNH6 KCNQ1 KCNQ1 HCN2 HCN2 CAMK2D CAMK2D ENSPTRP00000088766 ENSPTRP00000088766 MYH6 MYH6 SCN1B SCN1B ENSPTRP00000090392 ENSPTRP00000090392 ENSPTRP00000090501 ENSPTRP00000090501 RNLS RNLS SCN4B SCN4B SHOX2 SHOX2 ENSPTRP00000091918 ENSPTRP00000091918 CK820_G0029100 CK820_G0029100 ENSPTRP00000092784 ENSPTRP00000092784 KCNJ5 KCNJ5 NPPA NPPA EDN2 EDN2 TNNI3K TNNI3K CASQ2 CASQ2 HCN3 HCN3 RGS4 RGS4 CTNNA3 CTNNA3 ADRB1 ADRB1 ADM ADM SCN3B SCN3B CACNA1C CACNA1C KCNA5 KCNA5 PKP2 PKP2 ATP2A2 ATP2A2 EDNRB EDNRB HCN4 HCN4 YWHAE YWHAE TRPV1 TRPV1 RANGRF RANGRF GJD3 GJD3 JUP JUP KCNJ2 KCNJ2 DSC2 DSC2 DSG2 DSG2 PRKACA PRKACA CALM3 CALM3 HRC HRC TRPM4 TRPM4 FKBP1B FKBP1B EPAS1 EPAS1 BIN1 BIN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (221 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
ADRA1DADRA1D isoform 1. (568 aa)
SNTA1Syntrophin, alpha 1 (Dystrophin-associated protein A1, 59kDa, acidic component). (505 aa)
KCNE1KCNE1B isoform 1. (132 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TACR3Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (465 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HCN1HCN1 isoform 1. (886 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TMEM161BTransmembrane protein 161B. (502 aa)
ADRA1BADRA1B isoform 3. (518 aa)
DSPDSP isoform 1. (2871 aa)
EDN1EDN1 isoform 1. (212 aa)
BVESBlood vessel epicardial substance. (360 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif 2. (337 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CK820_G0013720HCN2 isoform 1. (847 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SREBF1SREBF1 isoform 6. (1177 aa)
ENSPTRP00000075494annotation not available (194 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (2565 aa)
ADAAdenosine deaminase. (412 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
GPD1LGlycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
DRD2D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. (490 aa)
DMDDMD isoform 3. (3685 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
EDN3EDN3 isoform 1. (238 aa)
ENSPTRP00000068927annotation not available (480 aa)
POPDC2Popeye domain containing 2. (368 aa)
PDE4DPhosphodiesterase. (809 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2377 aa)
AKAP9-2A-kinase anchoring protein 9. (3896 aa)
RYR2RYR2 isoform 1. (4941 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ADM2ADM2 isoform 1. (127 aa)
ENSPTRP00000063671annotation not available (122 aa)
CK820_G0042363TRPM4 isoform 1. (1251 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
KCND3Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family. (655 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
SPXChromosome 12 open reading frame 39. (116 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
KCNE2KCNE2 isoform 1. (123 aa)
SLC1A1Amino acid transporter. (524 aa)
AKAP9A kinase (PRKA) anchor protein (Yotiao) 9. (3908 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1159 aa)
ANK2ANK2 isoform 1. (3957 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
SRISRI isoform 1. (205 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
TPM1TPM1 isoform 3; Belongs to the tropomyosin family. (326 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (506 aa)
SRI-2SRI isoform 5. (237 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ENSPTRP00000082446annotation not available (194 aa)
CALM1CALM1 isoform 3; Belongs to the calmodulin family. (150 aa)
ADRA1AAdrenoceptor alpha 1A. (495 aa)
DMD-2Dystrophin. (643 aa)
LOC45963814-3-3 protein epsilon-like. (255 aa)
ENSPTRP00000085680annotation not available (88 aa)
ENSPTRP00000086934annotation not available (467 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (775 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (446 aa)
ENSPTRP00000088766annotation not available (199 aa)
MYH6MYH6 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2050 aa)
SCN1BSodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (268 aa)
ENSPTRP00000090392annotation not available (93 aa)
ENSPTRP00000090501annotation not available (192 aa)
RNLSRenalase, FAD-dependent amine oxidase. (342 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
SHOX2SHOX2 isoform 2. (343 aa)
ENSPTRP00000091918annotation not available (454 aa)
CK820_G0029100SRI isoform 2. (98 aa)
ENSPTRP00000092784annotation not available (75 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
NPPANatriuretic peptide A. (153 aa)
EDN2EDN2 isoform 1. (178 aa)
TNNI3KTNNI3K isoform 2. (835 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (774 aa)
RGS4Regulator of G protein signaling 4. (302 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
ADRB1Adrenoceptor beta 1. (476 aa)
ADMAdrenomedullin. (185 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2186 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
PKP2PKP2 isoform 1. (837 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Belongs to the 14-3-3 family. (255 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
GJD3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (293 aa)
JUPJunction plakoglobin. (745 aa)
KCNJ2Potassium inwardly-rectifying channel, subfamily J, member 2. (427 aa)
DSC2DSC2 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (901 aa)
DSG2DSG2 isoform 1. (1118 aa)
PRKACAPRKACA isoform 7; Belongs to the protein kinase superfamily. (289 aa)
CALM3Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
HRCHRC isoform 2. (693 aa)
TRPM4Transient receptor potential cation channel, subfamily M, member 4. (1306 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
EPAS1Endothelial PAS domain protein 1. (870 aa)
BIN1Bridging integrator 1. (597 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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