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PIK3R3 PIK3R3 SEMA3E SEMA3E LOXL2 LOXL2 THBS1 THBS1 VSTM4 VSTM4 YJEFN3-2 YJEFN3-2 ITGB1 ITGB1 TEK TEK ROBO1 ROBO1 ENSPTRP00000076822 ENSPTRP00000076822 EPHB4-2 EPHB4-2 MIA3 MIA3 SLIT2 SLIT2 LEF1 LEF1 BMP4-2 BMP4-2 AKT1 AKT1 ITGB1BP1 ITGB1BP1 E2F7 E2F7 ENSPTRP00000088702 ENSPTRP00000088702 PARVA PARVA ANGPT1 ANGPT1 EPHA2 EPHA2 NAXE NAXE NRP1 NRP1 MMRN2 MMRN2 E2F8 E2F8 ACVRL1 ACVRL1 EFNB2 EFNB2 BMP4 BMP4 CDH13 CDH13 RAMP2 RAMP2 JMJD6 JMJD6 RNF213 RNF213 CCBE1 CCBE1 TDGF1 TDGF1 KDR KDR VEGFC VEGFC SEMA5A SEMA5A OTULIN OTULIN ESM1 ESM1 ADTRP ADTRP GPLD1 GPLD1 SRF SRF RSPO3 RSPO3 DLL1 DLL1 BMPER BMPER EPHB4 EPHB4 EGR3 EGR3 PTK2B PTK2B ADGRA2 ADGRA2 RECK RECK NOTCH1 NOTCH1 VEGFD VEGFD NR4A1 NR4A1 CLEC14A CLEC14A NRARP NRARP FLT4 FLT4 VEGFB VEGFB RTN4 RTN4 YJEFN3 YJEFN3 PGF PGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R3Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma). (478 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (775 aa)
LOXL2LOXL2 isoform 4. (744 aa)
THBS1Thrombospondin 1. (1173 aa)
VSTM4V-set and transmembrane domain containing 4. (320 aa)
YJEFN3-2YjeF N-terminal domain containing 3. (299 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
ENSPTRP00000076822annotation not available (142 aa)
EPHB4-2EPH receptor B4. (987 aa)
MIA3MIA3 isoform 1. (1983 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
AKT1AKT1 isoform 3; Belongs to the protein kinase superfamily. (480 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
E2F7E2F transcription factor 7. (911 aa)
ENSPTRP00000088702annotation not available (170 aa)
PARVAPARVA isoform 1. (412 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
EPHA2EPH receptor A2. (976 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MMRN2MMRN2 isoform 1. (949 aa)
E2F8E2F transcription factor 8. (867 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
EFNB2EFNB2 isoform 1; Belongs to the ephrin family. (333 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CDH13CDH13 isoform 2. (760 aa)
RAMP2Receptor (G protein-coupled) activity modifying protein 2. (175 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (420 aa)
RNF213RNF213 isoform 1. (5256 aa)
CCBE1Collagen and calcium binding EGF domains 1. (406 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (188 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
SEMA5ASEMA5A isoform 1. (1074 aa)
OTULINOTULIN isoform 1. (352 aa)
ESM1Endothelial cell-specific molecule 1. (184 aa)
ADTRPAndrogen dependent TFPI regulating protein. (248 aa)
GPLD1GPLD1 isoform 2. (840 aa)
SRFSerum response factor (C-fos serum response element-binding transcription factor). (508 aa)
RSPO3RSPO3 isoform 1. (292 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
BMPERBMP binding endothelial regulator. (685 aa)
EPHB4EPH receptor B4. (987 aa)
EGR3Early growth response 3. (387 aa)
PTK2BPTK2B protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ADGRA2G protein-coupled receptor 124; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
RECKReversion-inducing-cysteine-rich protein with kazal motifs. (965 aa)
NOTCH1NOTCH1 isoform 1. (2555 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (652 aa)
CLEC14AC-type lectin domain containing 14A. (490 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
RTN4Reticulon. (1192 aa)
YJEFN3YjeF N-terminal domain containing 3. (299 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (221 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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