STRINGSTRING
RUNX3 RUNX3 MATN1 MATN1 ECM1 ECM1 BMPR1A BMPR1A LTBP3 LTBP3 SERPINH1 SERPINH1 SNX19 SNX19 WNT5B WNT5B SOX5 SOX5 WNT10B WNT10B FGF9 FGF9 RB1 RB1 BMP4 BMP4 HIF1A HIF1A TRIP11 TRIP11 ADAMTS7 ADAMTS7 SMPD3 SMPD3 AXIN2 AXIN2 SOX9 SOX9 TWSG1 TWSG1 MEX3C MEX3C TGFB1 TGFB1 OSR1 OSR1 SIX2 SIX2 EIF2AK3 EIF2AK3 COL3A1 COL3A1 IHH IHH NPPC NPPC BMP2 BMP2 GDF5 GDF5 PTH1R PTH1R MUSTN1 MUSTN1 IFT80 IFT80 CYTL1 CYTL1 BMPR1B BMPR1B SFRP2 SFRP2 GPLD1 GPLD1 MAPK14 MAPK14 HOXA11 HOXA11 GLI3 GLI3 CREB3L2 CREB3L2 EXT1 EXT1 CCN3 CCN3 COL27A1 COL27A1 COL2A1 COL2A1 SOX6 SOX6 CTNNB1 CTNNB1 ACCS ACCS TSKU TSKU BMPR2 BMPR2 HMGA2 HMGA2 WNT2B WNT2B AMELX AMELX COMP COMP NFIB NFIB ADAMTS12 ADAMTS12 ENSPTRP00000062696 ENSPTRP00000062696 ATF2 ATF2 ARID5A ARID5A SLC39A14 SLC39A14 ENSPTRP00000064416 ENSPTRP00000064416 WNT7A WNT7A TGFBI TGFBI RUNX2 RUNX2 COL11A2 COL11A2 IMPAD1 IMPAD1 ENSPTRP00000073126 ENSPTRP00000073126 SCX SCX SULF1 SULF1 MEF2D MEF2D TGFBR2 TGFBR2 ENSPTRP00000077262 ENSPTRP00000077262 ENSPTRP00000079262 ENSPTRP00000079262 BMP4-2 BMP4-2 ANXA6 ANXA6 SULF2 SULF2 RARG RARG SCUBE2 SCUBE2 CK820_G0045089 CK820_G0045089 COL11A1 COL11A1 FGFR3 FGFR3 ENSPTRP00000089565 ENSPTRP00000089565 ENSPTRP00000089584 ENSPTRP00000089584 CCN2 CCN2 MEF2C MEF2C FGF18 FGF18 SHOX2 SHOX2 CHST11 CHST11 RUNX1 RUNX1 OSR2 OSR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
MATN1MATN1 isoform 1. (496 aa)
ECM1Extracellular matrix protein 1. (540 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1297 aa)
SERPINH1Serpin peptidase inhibitor, clade H (Heat shock protein 47), member 1, (Collagen binding protein 1); Belongs to the serpin family. (418 aa)
SNX19Sorting nexin 19. (992 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
SOX5SRY (Sex determining region Y)-box 5. (765 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RB1RB transcriptional corepressor 1. (928 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
TRIP11TRIP11 isoform 1. (1979 aa)
ADAMTS7ADAMTS7 isoform 1. (932 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
MEX3CMEX3C isoform 2. (639 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
SIX2SIX homeobox 2. (291 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1116 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
NPPCNatriuretic peptide C. (126 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
GDF5GDF5 isoform 1. (501 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
MUSTN1Musculoskeletal embryonic nuclear protein 1 isoform X1. (87 aa)
IFT80Intraflagellar transport protein 80 homolog. (763 aa)
CYTL1CYTL1 isoform 1. (136 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SFRP2Secreted frizzled-related protein 2. (295 aa)
GPLD1GPLD1 isoform 2. (840 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
HOXA11HOXA11 isoform 2. (313 aa)
GLI3Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] (1580 aa)
CREB3L2cAMP responsive element binding protein 3-like 2. (520 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CCN3NOV isoform 1. (357 aa)
COL27A1COL27A1 isoform 1. (1860 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
SOX6SOX6 isoform 9. (828 aa)
CTNNB1Catenin (Cadherin-associated protein), beta 1, 88kDa. (781 aa)
ACCSExostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (891 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (891 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
AMELXAmelogenin X-linked. (205 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1509 aa)
ENSPTRP00000062696annotation not available (320 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ARID5AAT rich interactive domain 5A (MRF1-like). (594 aa)
SLC39A14SLC39A14 isoform 1. (490 aa)
ENSPTRP00000064416annotation not available (502 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
TGFBITransforming growth factor, beta-induced, 68kDa. (706 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
COL11A2COL11A2 isoform 2. (1736 aa)
IMPAD1Inositol monophosphatase domain containing 1. (388 aa)
ENSPTRP00000073126annotation not available (296 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (901 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (581 aa)
ENSPTRP00000077262annotation not available (314 aa)
ENSPTRP00000079262annotation not available (866 aa)
BMP4-2Bone morphogenetic protein 4. (408 aa)
ANXA6Annexin. (788 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
RARGRetinoic acid receptor, gamma. (456 aa)
SCUBE2SCUBE2 isoform 2. (996 aa)
CK820_G0045089RANBP3 isoform 23. (97 aa)
COL11A1Collagen type XI alpha 1 chain. (1818 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
ENSPTRP00000089565annotation not available (801 aa)
ENSPTRP00000089584annotation not available (842 aa)
CCN2CTGF isoform 1. (349 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SHOX2SHOX2 isoform 2. (343 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
OSR2Protein odd-skipped-related 2 isoform X4. (433 aa)
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.