17 items (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNN	TNN isoform 1. (1299 aa)
	MEN1	MEN1 isoform 14. (615 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	LRP5L	LDL receptor related protein 5 like. (252 aa)
	LIMD1	LIM domains containing 1. (676 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
	HOXA2	HOXA2 isoform 1. (376 aa)
	CLEC5A	C-type lectin domain containing 5A. (188 aa)
	GLI2	GLI family zinc finger 2. (1587 aa)
	ACHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (569 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	ENSPTRP00000071105	annotation not available (376 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
	JUND	JUND isoform 1. (346 aa)
	CLEC5A-2	C-type lectin domain containing 5A. (188 aa)
	SMAD3	Mothers against decapentaplegic homolog. (442 aa)

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000071105	SATB2	ENSPTRP00000071105	ENSPTRP00000080249	annotation not available	DNA-binding protein SATB.	0.468
GLI2	RUNX2	ENSPTRP00000040313	ENSPTRP00000065999	GLI family zinc finger 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.846
GLI2	SHH	ENSPTRP00000040313	ENSPTRP00000075730	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.846
GLI2	SMAD3	ENSPTRP00000040313	ENSPTRP00000090625	GLI family zinc finger 2.	Mothers against decapentaplegic homolog.	0.530
HOXA2	SATB2	ENSPTRP00000032491	ENSPTRP00000080249	HOXA2 isoform 1.	DNA-binding protein SATB.	0.468
JUND	MEN1	ENSPTRP00000077628	ENSPTRP00000006635	JUND isoform 1.	MEN1 isoform 14.	0.963
JUND	SMAD3	ENSPTRP00000077628	ENSPTRP00000090625	JUND isoform 1.	Mothers against decapentaplegic homolog.	0.627
LRP5	PTH1R	ENSPTRP00000068813	ENSPTRP00000025621	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.470
LRP5	RUNX2	ENSPTRP00000068813	ENSPTRP00000065999	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.667
MEN1	JUND	ENSPTRP00000006635	ENSPTRP00000077628	MEN1 isoform 14.	JUND isoform 1.	0.963
MEN1	SMAD3	ENSPTRP00000006635	ENSPTRP00000090625	MEN1 isoform 14.	Mothers against decapentaplegic homolog.	0.852
PTH1R	LRP5	ENSPTRP00000025621	ENSPTRP00000068813	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.470
PTH1R	RUNX2	ENSPTRP00000025621	ENSPTRP00000065999	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.467
RUNX2	GLI2	ENSPTRP00000065999	ENSPTRP00000040313	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	GLI family zinc finger 2.	0.846
RUNX2	LRP5	ENSPTRP00000065999	ENSPTRP00000068813	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.667
RUNX2	PTH1R	ENSPTRP00000065999	ENSPTRP00000025621	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.467
RUNX2	SATB2	ENSPTRP00000065999	ENSPTRP00000080249	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	DNA-binding protein SATB.	0.757
RUNX2	SHH	ENSPTRP00000065999	ENSPTRP00000075730	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.615
RUNX2	SMAD3	ENSPTRP00000065999	ENSPTRP00000090625	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Mothers against decapentaplegic homolog.	0.892
SATB2	ENSPTRP00000071105	ENSPTRP00000080249	ENSPTRP00000071105	DNA-binding protein SATB.	annotation not available	0.468